Role Of Excitatory Amino Acid Inputs To The Rostral Ventrolateral Medulla In Cardiovascular Regulation

Clinical and Experimental Pharmacology and Physiology - Tập 29 Số 5-6 - Trang 503-506 - 2002
Alan F. Sved1, Satoru Ito2, Yoshiharu Yajima3
1Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
2Second Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan
3Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania, USA and

Tóm tắt

SUMMARY1. Excitatory amino acid (EAA)‐mediated neural transmission in the rostral ventrolateral medulla (RVLM) is important for many cardiovascular reflexes, although the receptor subtypes involved vary depending on the specific response.2. Although injection of the EAA ionotropic receptor antagonist kynurenic acid into the RVLM has no effect on baseline arterial pressure, this lack of effect appears to result from EAA inputs to RVLM exciting both excitatory and inhibitory mechanisms within the RVLM.3. The balance between EAA‐mediated excitation and inhibition of RVLM neurons may be shifted to excitation in experimental models of hypertension.4. The excitatory influence that EAA inputs to the RVLM have on vasomotor neurons in the RVLM may involve a sarthran‐sensitive intermediary in the RVLM.

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Clinical and Experimental Pharmacology and Physiology

Tập 29 Số 5-6

503-506

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