Risk prediction of recurrent venous thrombosis; where are we now and what can we add?

Prandoni, 2007, The risk of recurrent venous thromboembolism after discontinuing anticoagulation in patients with acute proximal deep vein thrombosis or pulmonary embolism. A prospective cohort study in 1626 patients, Haematologica, 92, 199, 10.3324/haematol.10516 Hansson, 2000, Recurrent venous thromboembolism after deep vein thrombosis: incidence and risk factors, Arch Intern Med, 160, 769, 10.1001/archinte.160.6.769 Boutitie, 2011, Influence of preceding length of anticoagulant treatment and initial presentation of venous thromboembolism on risk of recurrence after stopping treatment: analysis of individual participants’ data from seven trials, BMJ, 342, d3036, 10.1136/bmj.d3036 van Rein, 2016, Objectives and design of BLEEDS: a cohort study to identify new risk factors and predictors for major bleeding during treatment with vitamin K antagonists, PLoS ONE, 11, e0164485, 10.1371/journal.pone.0164485 Jun, 2017, Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study, BMJ, 359, j4323, 10.1136/bmj.j4323 Naess, 2007, Incidence and mortality of venous thrombosis: a population‐based study, J Thromb Haemost, 5, 692, 10.1111/j.1538-7836.2007.02450.x Tagalakis, 2013, Incidence of and mortality from venous thromboembolism in a real‐world population: the Q‐VTE Study Cohort, Am J Med, 126, 832.e13, 10.1016/j.amjmed.2013.02.024 Kyrle, 2010, Risk assessment for recurrent venous thrombosis, Lancet, 376, 2032, 10.1016/S0140-6736(10)60962-2 Rodger, 2008, Identifying unprovoked thromboembolism patients at low risk for recurrence who can discontinue anticoagulant therapy, CMAJ, 179, 417, 10.1503/cmaj.080493 Eichinger, 2010, Risk assessment of recurrence in patients with unprovoked deep vein thrombosis or pulmonary embolism: the Vienna prediction model, Circulation, 121, 1630, 10.1161/CIRCULATIONAHA.109.925214 Tosetto, 2012, Predicting disease recurrence in patients with previous unprovoked venous thromboembolism: a proposed prediction score (DASH), J Thromb Haemost, 10, 1019, 10.1111/j.1538-7836.2012.04735.x Tritschler, 2015, Predicting recurrence after unprovoked venous thromboembolism: prospective validation of the updated Vienna Prediction Model, Blood, 126, 1949, 10.1182/blood-2015-04-641225 Marcucci, 2015, Risk of recurrence after a first unprovoked venous thromboembolism: external validation of the Vienna Prediction Model with pooled individual patient data, J Thromb Haemost, 13, 775, 10.1111/jth.12871 Tosetto, 2017, External validation of the DASH prediction rule: a retrospective cohort study, J Thromb Haemost, 15, 1963, 10.1111/jth.13781 Rodger, 2017, Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study, BMJ, 356, j1065, 10.1136/bmj.j1065 Kearon, 2016, Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report, Chest, 149, 315, 10.1016/j.chest.2015.11.026 Konstantinides, 2014, 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism, Eur Heart J, 35, 3033, 10.1093/eurheartj/ehu283 Kearon, 2016, Categorization of patients as having provoked or unprovoked venous thromboembolism: guidance from the SSC of ISTH, J Thromb Haemost, 14, 1480, 10.1111/jth.13336 Rodger, 2018, “HERDOO2” clinical decision rule to guide duration of anticoagulation in women with unprovoked venous thromboembolism. Can I use any d‐Dimer?, Thromb Res, 169, 82, 10.1016/j.thromres.2018.07.020 Ocak, 2013, Risk of venous thrombosis in patients with major illnesses: results from the MEGA study, J Thromb Haemost, 11, 116, 10.1111/jth.12043 Timp, 2015, Predictive value of factor VIII levels for recurrent venous thrombosis: results from the MEGA follow‐up study, J Thromb Haemost, 13, 1823, 10.1111/jth.13113 Eichinger, 2014, D‐dimer levels over time and the risk of recurrent venous thromboembolism: an update of the Vienna prediction model, J Am Heart Assoc, 3, e000467, 10.1161/JAHA.113.000467 Palareti, 1994, Activation of blood coagulation after abrupt or stepwise withdrawal of oral anticoagulants—a prospective study, Thromb Haemost, 72, 222, 10.1055/s-0038-1648843 Cundiff, 2008, Clinical evidence for rebound hypercoagulability after discontinuing oral anticoagulants for venous thromboembolism, Medscape J Med, 10, 258 Martinez, 2016, Risk of recurrent venous thromboembolism after discontinuation of vitamin K antagonist treatment: a nested case‐control study, J Thromb Haemost, 14, 1374, 10.1111/jth.13337 Lijfering, 2019, Predicting the risk of recurrent venous thrombosis: what the future might bring, J Thromb Haemost, 10.1111/jth.14534