Risk factors for human papillomavirus persistence among women undergoing cold‐knife conization for treatment of high‐grade cervical intraepithelial neoplasia

International Journal of Gynecology & Obstetrics - Tập 125 - Trang 275-278 - 2014
Eralp Baser1, Emre Ozgu1, Selcuk Erkilinc1, Cihan Togrul1, Mete Caglar1, Tayfun Gungor1
1Department of Gynecologic Oncology, Zekai Tahir Women’s Health Education and Research Hospital, Ankara, Turkey

Tóm tắt

AbstractObjectiveTo investigate the risk factors potentially associated with high‐risk human papillomavirus (HPV) persistence in women undergoing cold‐knife conization (CKC) for treatment of high‐grade cervical intraepithelial neoplasia (CIN).MethodsMedical records of women who underwent CKC for treatment of CIN 2/3 between 2007 and 2012 at a tertiary hospital in Ankara, Turkey, were retrospectively analyzed. Cases involving persistent HPV infection after 1 year of follow‐up were identified. Using univariate and multivariate analyses, the impact of various factors such as patient age, menopausal status, parity, high‐risk HPV type, excised cone dimensions (width, height, and depth), and surgical margin status on high‐risk HPV persistence was assessed.ResultsA total of 292 women underwent CKC for treatment of CIN 2/3 within the study period. After women with a subsequent diagnosis of cervical cancer, subsequent total hysterectomy, and inadequate follow‐up data were eliminated, 113 women were eligible for final analysis. High‐risk HPV persistence was detected in 24 (21.2%) women, and multivariate analysis revealed that patient age and cone depth were significant independent predictors (P < 0.05).ConclusionHigh‐risk HPV persistence may be encountered after CKC procedures. It is important to evaluate persistent HPV infections after treatment because affected women are at increased risk for disease persistence, recurrence, and progression.

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Thông tin xuất bản

International Journal of Gynecology & Obstetrics

Tập 125

275-278

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