Risk factors and peripheral biomarkers for schizophrenia spectrum disorders: an umbrella review of meta‐analyses

Acta Psychiatrica Scandinavica - Tập 137 Số 2 - Trang 88-97 - 2018
Lazaros Belbasis1, Cristiano A. Köhler2, Nikos C. Stefanis3, Brendon Stubbs4,5, Jim van Os6,7, Eduard Vieta8, Mary V. Seeman9, Celso Arango10, André F. Carvalho11,12, Εvangelos Εvangelou13,1
1Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece
2Translational Psychiatry Research Group, Department of Clinical Medicine Federal University of Ceará Medical School Fortaleza Brazil
3Department of Psychiatry Eginition Hospital National and Kapodistrian University of Athens Medical School Athens Greece
4Department of Health Service and Population Research, Institute of Psychiatry, King's College London, London, UK
5Department of Physiotherapy, South London and Maudsley NHS Foundation Trust, London, UK
6Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Centre Utrecht, Utrecht, The Netherlands
7Department of Psychosis Studies, Institute of Psychiatry, King’s College London, London, UK
8Bipolar Disorder Unit Institute of Neuroscience University of Barcelona, IDIBAPS and CIBERSAM Barcelona Spain
9Institute of Medical Science, University of Toronto, Toronto, ON, Canada
10Department of Child and Adolescent Psychiatry University Hospital Gregorio Marañón Complutense University of Madrid Medical School, CIBERSAM Madrid Spain
11Centre for Addiction & Mental Health (CAMH) Toronto, ON Canada
12Department of Psychiatry, University of Toronto, Toronto, ON, Canada
13Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK

Tóm tắt

ObjectiveThis study aimed to systematically appraise the meta‐analyses of observational studies on risk factors and peripheral biomarkers for schizophrenia spectrum disorders.MethodsWe conducted an umbrella review to capture all meta‐analyses and Mendelian randomization studies that examined associations between non‐genetic risk factors and schizophrenia spectrum disorders. For each eligible meta‐analysis, we estimated the summary effect size estimate, its 95% confidence and prediction intervals and the I2 metric. Additionally, evidence for small‐study effects and excess significance bias was assessed.ResultsOverall, we found 41 eligible papers including 98 associations. Sixty‐two associations had a nominally significant (P‐value <0.05) effect. Seventy‐two of the associations exhibited large or very large between‐study heterogeneity, while 13 associations had evidence for small‐study effects. Excess significance bias was found in 18 associations. Only five factors (childhood adversities, cannabis use, history of obstetric complications, stressful events during adulthood, and serum folate level) showed robust evidence.ConclusionDespite identifying 98 associations, there is only robust evidence to suggest that cannabis use, exposure to stressful events during childhood and adulthood, history of obstetric complications, and low serum folate level confer a higher risk for developing schizophrenia spectrum disorders. The evidence on peripheral biomarkers for schizophrenia spectrum disorders remains limited.

Từ khóa


Tài liệu tham khảo

10.1093/epirev/mxn001

10.1016/j.psc.2007.04.007

10.1016/S0140-6736(12)61689-4

10.1016/S2215-0366(17)30078-0

10.1001/jamapsychiatry.2014.2502

10.1093/schbul/sbu069

10.1016/j.schres.2011.09.020

10.1186/s12888-015-0562-2

10.1093/ije/dyh132

10.1503/cmaj.081086

10.1016/S1474-4422(14)70267-4

10.1016/j.parkreldis.2015.12.008

10.1016/j.jalz.2016.07.152

10.1159/000443146

10.1016/j.jdermsci.2016.09.003

10.1186/s12916-016-0692-5

World Health Organization.Health topics: Risk factors.http://www.who.int/topics/risk_factors/en/

10.1016/j.eurpsy.2016.09.003

Lawlor DA, 2017, Triangulation in aetiological epidemiology, Int J Epidemiol, dyw314, 10.1093/ije/dyw314

10.1002/sim.3034

10.1016/0197-2456(86)90046-2

10.7326/0003-4819-127-9-199711010-00008

10.1111/j.1467-985X.2008.00552.x

10.1093/ije/dyn204

10.1002/sim.1186

10.1136/bmj.d4002

10.1136/bmj.315.7109.629

10.1177/1740774507079441

10.1016/j.jmp.2013.03.002

10.1016/j.jclinepi.2007.11.008

10.1038/mp.2016.252

10.1017/S0033291716003172

10.1371/journal.pmed.1001976

10.1093/schbul/sbt120

10.1038/srep26496

10.1093/schbul/sbw003

10.1002/wps.20341

10.1001/jamapsychiatry.2015.3278

10.1017/S0033291709992121

10.1037/a0037459

10.1016/S0140-6736(15)01121-6

10.1093/schbul/sbs096

10.1016/j.schres.2009.06.017

10.1093/schbul/sbr091

10.1016/j.schres.2011.10.026

10.1017/S0033291710001406

10.1176/appi.ajp.162.1.12

10.1007/s00127-016-1261-0

10.1038/nn.4409

10.1159/000441457

10.1017/S0033291716000957

10.1038/ng.171

10.1038/srep26105

10.1177/1049731505284391

10.1371/journal.pone.0053187

10.1093/schbul/sbt065

10.1192/bjp.167.6.786

10.1038/mp.2016.3

10.1038/mp.2010.88

10.1016/S2215-0366(15)00152-2

10.1093/schbul/sbs050

10.1016/j.psychres.2015.11.045

Thông tin
Thông tin xuất bản

Acta Psychiatrica Scandinavica

Tập 137 Số 2

88-97

Thông tin tác giả