Riot control agents: pharmacology, toxicology, biochemistry and chemistry
Tóm tắt
The desired effect of all riot control agents is the temporary disablement of individuals by way of intense irritation of the mucous membranes and skin. Generally, riot control agents can produce acute site‐specific toxicity where sensory irritation occurs. Early riot control agents, namely, chloroacetophenone (CN) and chlorodihydrophenarsazine (DM), have been replaced with ‘safer’ agents such as
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Prentiss AM, 1937, Chemicals in War: a Treatise on Chemical Warfare
Jacobs MB, 1942, War Gases, Their Identification and Decontamination
Waitt AH, 1942, Gas Warfare
Sartori M, 1943, The War Gases
National Academy of Sciences, 1984
Robinson J, 1968, Chemical and Biological Warfare
Volmer K, 1969, La querre chimique, Genie, 10, 21
World Health Organization (WHO), 1970, Health Aspects of Chemical and Biological Weapons
Hu H, 1992, Chemical Warfare Agents, 271
National Research Council, 1999, Chemical and Biological Terrorism
Cookson J, 1969, A Survey of Chemical and Biological Warfare, 183
Verwey WD, 1977, Riot Control Agents and Herbicides in War
Suzuki T, 1984, 228
Compton J, 1987, Military Chemical and Biological Agents—Chemical and Biological Properties
Maynard RL, 1993, General and Applied Toxicology, 1253
Sidell FR, 1997, Textbook of Military Medicine, Medical Aspects of Chemical and Biological Warfare, 307
US Army, Center for Health Promotion and Preventive Medicine (CHPPM), Detailed and General Facts about Chemical Agents—TG 218
Departments of the Army, The Navy, and The AirForce, 1990, Treatment of Chemical Agent Casualties and Conventional Military Chemical Injuries
Takafuji ET, 1997, Textbook of Military Medicine, Medical Aspects of Chemical and Biological Warfare, 111
The White House, Office of the Press Secretary, 1994, Press Release dated June 23, 1994 (Subject: Riot Control Agents)
Swearengen TF, 1966, Tear Gas Munitions
Royer J, 1973, Ocular effects of ethyl bromoacetate tear gas, Bull Soc. Ophthalmol. Fr., 73, 1165
Rothschild JH, 1964, Tommorrow's Weapons
Rose S, 1969, CS—a case for concern, New Sci., 468
Jones GRN, 1971, CS in the balance, New Sci. Sci. J., 50, 690
Ballantyne B, 1977, Medical Annual, 7
MacLeod IF, 1969, Chemical Mace ® ocular effects in rabbits and monkeys, J. Forens. Sci., 14, 34
Hoffmann DH, 1965, Injuries of the eyes from short range discharge of tear gas weapons, Klin. Monatsbl. Augenheilkd., 147, 625
Bregeat P, 1968, Ocular injuries by lacrimogenic agents, Bull. Soc. Ophthalmol. (France), 68, 531
Rengstorff RH, 1969, Tear gas and riot control agents: a review of eye effects, Optometr. Week., 60, 25
Rose L, 1969, Mace, a dangerous police weapon, Ophthalmologica (Basel), 158, 448
Grant WM, 1986, Toxicology of the Eye, 882
Buck SH, 1986, The neuropharmacology of capsaicin: review of some recent observations, Pharmacol. Rev., 38, 179
Rengstorff RH, 1969, The effects of the riot control agent CS on visual acuity, Milit. Med., 134, 219, 10.1093/milmed/134.3.219
Rengstorff RH, 1971, CS in water: II effects on human eyes, Milit. Med., 136, 149, 10.1093/milmed/136.2.149
Rengstorff RH, 1971, CS in trioctyl phosphate: effects on human eyes, Milit. Med., 136, 152, 10.1093/milmed/136.2.152
Rengstorff RH, 1971, CS in water: effects of massive doses sprayed into eyes of rabbits, Milit. Med., 136, 146, 10.1093/milmed/136.2.146
Owens EJ, 1970, Technical Report No. 4446, October 1970
Biskup RC, 1975, Technical Report EB‐TR‐75009 (May 1975)
HoggMAP. Data as reported in Ref. 521974.
Ballantyne B, 1973, The presentation and management of individuals contaminated with solutions of dibenzoxazepine (CR), Med. Sci. Law, 13, 265, 10.1177/002580247301300409
Macrae WG, 1970, Corneal injury caused by aerosol irritant projectors, Can. J. Ophthalmol., 5, 3
Leopold IH, 1971, Chemical injuries of the cornea, Fed. Proc. Am. Soc. Exp. Biol., 30, 92
McNamara BP, 1969, Edgwood Arsenal Technical Report, EATR 4309
Grant WM, 1974, Toxicology of the Eye, 260
Gutentag PJ, 1960, Technical Report CWLR 2365
Bowers MB, 1960, CWL Technical Memorandum 24–50
Weigand DA, 1969, Cutaneous reaction to the riot control agent CS, Milit. Med., 134, 437, 10.1093/milmed/134.6.437
Rothberg S, 1970, Skin sensitization potential of the riot control agents BBC, DM, CN, and CS in guinea pigs, Milit. Med., 135, 552, 10.1093/milmed/135.7.552
Hellrich A, 1967, Technical Report EATR 4075
Fuchs T, 1990, Zur frage der kontaktallergien auf CN und CS (tranengas) bei demonstrationsteilnehmern, H + G Z. Hautkrank., 65, 288
Weigand DA, 1970, Edgewood Arsenal Technical Report No. EATR‐4413
Penneys NS, 1971, Contact dermatitis to chloroacetophenone, Fed. Proc., 30, 96
Chung CW, 1972, Sensitization of guinea pigs to alpha‐chloroacetophenone (CN) and ortho‐chlorobenzylidene malononitrile (CS), tear gas chemicals, J. Immunol., 109, 284, 10.4049/jimmunol.109.2.284
Molnar J, 1965, Die pharmakologischen wirkungen des capsaicins, des chaf schmeckenden wirkstoffes im paprika, Arzneim. Forsch., 15, 718
Makara GB, 1971, Superficial and deep chemonociception: differential inhibition by pre‐treatment with capsaicin, Acta Physiol. Acad. Sci. Hung., 38, 393
FEMA (Flavor and Extract Manufacturers' Association of the U.S.), 1978, FDA Report No. PB‐284868
Jancso G, 1987, Neurotoxic effect of capsaicin in mammals, Acta Physiol. Hung., 69, 295
Fuller RW, 1990, The human pharmacology of capsaicin, Arch. Int. Pharmacodyn., 303, 147
Holzer P, 1992, Capsaicin: selective toxicity for thin primary sensory neurons, Handb. Exp. Pharmacol., 102, 419
Szolcsanyi J, 1993, Capsaicin in the Study of Pain, 1
Keller U, 1980, Quality of Selected Fruits and Vegetables in North America, 137
Clede B, 1993, Oleoresin capsicum, Law Order, 63
Issekutz B, 1950, Effect of capsaicin and histamine on heat regulation, Arch. Int. Pharmacodyn. Ther., 81, 35
Issekutz B, 1950, Effect of histamine, capsaicine and procaine on heat regulation, Arch. Int. Pharmacodyn. Ther., 83, 319
Porszasz J, 1955, Cardiovascular and respiratory effects of capsaicin, Acta Physiol. Acad. Sci. hung., 8, 60
Porszasz J, 1957, Circulatory and respiratory chemoreflexes I. analysis of the site of action and receptor types of capsaicine, Acta Physiol. Acad. Sci. Hung., 12, 189
Holzer P, 1991, Capsaicin: cellular targets, mechanisms of action, and selectivity for thin sensory neurons, Pharmacol. Rev., 43, 143
Jancso N, 1968, 33
Jancso G, 1985, Tachykinin Antagonists, 35
Scadding JW, 1980, The permanent anatomical effects of neonatal capsaicin on somatosensory nerves, J. Anat., 131, 473
Szolcsanyi J, 1977, A pharmacological approach to elucidation of the role of different nerve fibers and receptor endings in the mediation of pain, J. Physiol. (Paris), 73, 251
Szolcsanyi J, 1980, Effect of pain‐producing chemical agents on the activity of slowly‐conducting afferent fibres, Acta. Physiol. Acad. Sci. Hung., 56, 86
Szolcsanyi J, 1984, Antidromic Vasodilatation and Neurogenic Inflammation, 7
Szolcsanyi J, 1984, Antidromic Vasodilatation and Neurogenic Inflammation, 27
Szolcsanyi J, 1987, Capsaicin and nociception, Acta. Physiol. Hung., 69, 323
Nagy JI, 1983, Dose‐dependent effects of capsaicin on primary sensory neurons in the neonatal rat, J. Neurosci., 3, 399, 10.1523/JNEUROSCI.03-02-00399.1983
Matsumiya T, 1983, The effect of capsaicinon C‐fiber reflex and heat evoked discharge in the acute spinal cat, Tokai J. Exp. Clin. Med., 8, 325
Lawson SN, 1984, Antidromic Vasodilation and Neurogenic Inflammation, 111
Bevan SJ, 1987, Neurotoxins and their Pharmacological Implications, 261
Lynn B, 1987, The immediate and long‐term effects of applying capsaicin to cutaneous nerves, Acta Physiol. Hung., 69, 287
Szolcsanyi J, 1981, 39
Holzer P, 1993, Capsaicin in the Study of Pain, 191
Campbell E, 1993, Capsaicin in the Study of Pain, 256
Ritter S, 1993, Capsaicin in the Study of Pain, 106
Jancso N, 1960, Role of the nerve terminals in the mechanism of inflammatory reactions, Bull. Millard Filmore Hosp. (Buffalo, NY), 7, 53
Jancso‐Gabor A, 1969, Inflammation Biochemistry and Drug Interaction, 210
Jancso G, 1984, Antidromic Vasodilatation and Neurogenic Inflammation, 207
Coleridge JCG, 1984, Afferent vagal C‐fibre innervation of the lung and airways and its functional significance, Rev. Physiol. Biochem. Pharmacol., 99, 1
Lundblad L, 1984, Protective reflexes and vascular effects in the nasal mucosa elicited by activation of capsaicin‐sensitive substance P‐immunoreactive trigeminal neurons, Acta Physiol. Scand. Suppl., 529, 1
Crayton SC, 1981, Reflex cardiovascular response during injection of capsaicin into skeletal muscle, Am. J. Physiol., 240, H315
Russel JA, 1979, Reflex bronchoconstriction induced by capsaicin in the dog, J. Appl. Physiol., 47, 961, 10.1152/jappl.1979.47.5.961
Martling CR, 1987, Sensory nerves containing tachykinins and CGRP in the lower airways, Acta Physiol. Scand., 130, 1
Martins MA, 1991, Capsaicin‐induced release of tachykinins: effects of enzyme inhibitors, J. Appl. Physiol., 70, 1950, 10.1152/jappl.1991.70.5.1950
Adcock JJ, 1989, Inhibition of reflex bronchoconstriction by the opioid peptide BW 443C81 in the anaesthetized cat, Br. J. Pharmacol., 96, 596
Chahl LA, 1987, The acute effects of capsaicin on the cardiovascular system, Acta. Physiol. Hung., 69, 413
Porszasz R, 1991, Circulatory and respiratory effects of capsaicin and resiniferatoxin on guinea pigs, Acta Biochim. Biophys. Hung., 26, 131
Jancso N, 1966, Effect of capsaicin on thermoregulation, Acta Physiol. Acad. Sci. Hung., 29, 364
Szolcsanyi J, 1973, Proceedings of the Satellite Symposium on the Pharmacology of Thermoregulation, 395
Cabanac M, 1977, Drugs, Biogenic Amines and Body Temperature, 99
Hori T, 1977, The effect of capsaicin on behavioral thermogregulation, J. Physiol. Soc. Jpn., 39, 266
Hori T, 1980, Thermoregulatory Mechanisms and Their Therapeuticum Implications, 214
Hori T, 1978, Thermoregulation of rats desensitized by capsaicin in the early postnatal life, Jpn. J. Biometeorol., 15, 9
Frens J, 1977, Drugs, biogenic amines and Body Temperature, 20
Sambaiah K, 1978, Effect of red pepper (chillies) and capsaicin on fat absorption and liver fat in rats, Nutr. Rep. Int., 18, 521
Sambaiah K, 1984, Influence of capsaicin on the absorption of amino acids and fat in rats, J. Food Sci. Technol., 21, 155
Sambaiah K, 1982, Lipotropic‐like activity of red pepper, J. Food Sci. Technol., 19, 30
Hayes AG, 1980, The antinociceptive effects of single doses of capsaicin in the rodent, Br. J. Pharmacol., 70, 96p
Miller MS, 1980, Dihydrocapsaicin‐induced hypothermia and substance P depletion in rats, Pharmacologist, 22, 206
Miller MS, 1981, Substance P depletion and analgesia induced by capsaicin analogs in the guinea‐pig, Fed. Proc., 40, 274
Beswick FW, 1972, Acute effects of exposure to orthochloro‐benzylidene malononitrile (CS) and the development of tolerance, Br. J. Ind. Med., 29, 298
Alarie Y, 1973, Sensory irritation by sulfur dioxide and chlorobenzylidene malonitrile, Environ. Physiol. Biochem., 3, 53
Marrs TC, 1983, Late inhalation toxicology and pathology produced by exposure to a single dose of 2‐chlorobenzylidene malononitrile (CS) in rats and hamsters, Med. Sci. Law, 23, 257, 10.1177/002580248302300406
Biscoe TJ, 1962, Some responses to the intravascular injection of o‐chlorobenzal malononitrile in cats and dogs, Arch. Int. Pharmacodyn. Ther., 138, 381
Cucinell SA, 1971, Biochemical interactions and metabolic fate of riot control agents, Fed. Proc., 30, 86
Lim RKS, 1968, Pharmacology of Pain–Proceedings of the Third International Congress on Pharmacology
Pattle RE, 1974, Lung surfactant and organelles after an exposure to dibenzoxazepine (CR), T. Br. J. Exp. Pathol., 55, 213
Colgrave HF, 1979, Ultrastructure of rat lungs following exposure to aerosols of dibenzoxazepine (CR), Br. J. Exp. Pathol., 60, 130
Lundy PM, 1975, Suffield Technical Paper No. 438
Lundy PM, 1977, Suffield Technical Paper No. 465
British Ministry of Defence, 1972, Medical Manual of Defence Against Chemical Agents
Owens EJ, 1967, Technical Report 4108
Striker GE, 1967, Technical Report 4070
Striker GE, 1967, Technical Report 4072
Lee SO, 1963, Studies on the influence of diets and lipotrophic substances upon the various organs and metabolic changes in rabbits on long‐term feeding with red pepper. I. Histopathological changes of the liver and spleen, Korean J. Int. Med., 6, 383
Lee SO, 1963, Studies on the influence of diet and lipotrophic substances upon the various organs and metabolic changes in rabbits on long‐term feeding with red pepper. II. Histopathological changes of various organs except the liver and spleen, Korean J. Int. Med., 8, 471
Nopanitaya W, 1973, Long‐term effects of capsaicin on fat absorption and the growth of the rat, Growth, 37, 269
Monsereenusorn Y, 1983, Subchronic toxicity studies of capsaicin and capsicum in rats, Res. Comun. Chem. Pathol. Pharmacol., 41, 95
US Army, Edgewood Arsenal (Chemical Research and Development Laboratories), 1965, Special Summary Report: The Toxicology of CN, CS, and DM (September, 1965)
McNamara BP, 1972, Edgewood Arsenal Technical Report, EATR 4675
Marrs TC, 1982, A repeated‐dose study of the toxicity of dibenzo (b,f)‐1‐4‐oxazepine applied to the skin of mice, Toxicol Lett., 13, 259
Husain K, 1991, A comparative study of biochemical changes induced by inhalation of aerosols of o‐chloroacetophenone and dibenz (b,f)‐1,4‐oxazepine in rats, Indian J. Med. Res., 94, 76
National Institutes of Health, 1990, Toxicology and Carcinogenesis Studies of 2‐Chloroacetophenone (CAS No. 532‐27‐4) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Toth B, 1984, Tumorigenicity and mutagenicity studies with capsaicin of hot peppers, Anticancer Res., 4, 117
Tajima K, 1985, Dietary habits and gastro‐intestinal cancers: a comparative case‐control study of stomach and large intestinal cancers in Nagoya, Japan, Jpn. J. Cancer Res., 76, 705
Sirsat SM, 1962, Submucous fibrosis of the palate and pillars of the fauces, Ind. J. Med. Sci., 16, 189
Toth B, 1992, Carcinogenicity of lifelong administration of capsaicin of hot pepper in mice, In Vivo, 6, 59
LaHann TR, 1986, Effect of capsaicin on croton oil and TPA‐induced tumorigenesis and inflammation, Proc. West. Pharmacol. Soc., 29, 145
Sasajima K, 1987, Effects of tumor promoters and cocarcinogens on growth and differentiation of cultured human esophageal epithelial cells, J. Natl. Cancer Inst., 28, 419
National Institutes of Health, 1990, Toxicology and Carcinogenesis Studies of CS2 (94% o‐Chlorobenzalmalononitrile) (CAS no. 2698‐41‐1) in F344/N Rats and B6C3F1 Mice (Inhalation Studies)
Colgrave HF, 1983, Repeated‐dose inhalation toxicity and mutagenicity‐status of CR (dibenz (b.f.)‐1,4, oxazepine), Br. J. Pharmacol., 78, 169p
Grady HG, 1940, Histogenesis of induced pulmonary tumors in strain A mice, Am. J. Pathol., 16, 417
Stewart HL, 1979, The Mouse), 251
Kim ND, 1981, Study on the absorption and extraction of capsaicin in rabbits, J. Pharm. Soc. Korea, 25, 1010
Lee SS, 1980, 1009
Patai S, 1962, Nucleophilic attacks on carbon‐carbon double bonds. Part II. Cleavage of arylmethylenemaloninitriles by water in 95% ethanol, J. Chem. Soc. (London), 71, 383
Nash JB, 1950, Effects of cyanide antidotes and inanition on acute lethal toxicity of malononitrile in mice, Arch. Int. Pharmacodyn., 84, 385
Feinsilver L, 1971, Edgewood Arsenal Technical Report Series No. 4521
Swentzel KC, 1970, Edgewood Arsenal Technical Memorandum, EATM 100‐8
Upshall DG, 1977, Clinical Toxicology, 121
Stjarne P, 1991, Sensory and motor reflex control of nasal mucosal blood flow and secretion: clinical implications in non‐allergic nasal hyperreactivity, Acta Physiol. Scand., 142, 1
Saria A, 1985, Tachykinin Antagonists, 149
Umeno E, 1990, Neurogenic inflammation of the rat trachea: fate of neutrophils that adhere to venules, J. Appl. Physiol., 69, 2131, 10.1152/jappl.1990.69.6.2131
Nilsson G, 1977, Substance P, 57
Burks TF, 1985, Mechanism of depletion of substance P by capsaicin, Fed. Proc., 44, 2531
Maggi CA, 1993, Capsaicin in the Study of Pain, 161
Pernow B, 1953, Studies on substance P: Purification, occurrence and biological actions, Acta Physiol. Scand., 29, 1
Pernow B, 1983, Substance P, Pharmacol. Rev., 35, 85
Tadic V, 1989, Endogenous opioid release: an alternative mechanism of cyanide toxicity, Iugosl. Physiol. Pharmacol. Acta, 25, 143
Sakaida I, 1990, Phospholipid metabolism in cyanide‐intoxicated hepatocytes, Toxicologist, 10, 103
Dixon M, 1948, Reactions of lachrymators with enzymes and proteins, Biochem. J., 42, xxvi
Lovre SC, 1970, Technical Report EATR 4399
Smith CG, 1999, Heath hazards of pepper spray, North Carolina Med. J., 60, 150
Onnen J, 1993, Executive Brief (June 1993), Science and Technology
Weaver W, 1989, Oleoresin Capsicum Training and Use
Granfield J, 1994, Executive Brief (March. 1994), Science and Technology
Lifschultz BD, 1991, Deaths in custody, Legal Med., 45
Billmire DF, 1996, Pepper‐spray‐induced respiratory failure treated with extracorporeal membrane oxygenation, Pediatrics, 98, 961, 10.1542/peds.98.5.961
Fuller RW, 1988, Effect of inhaled and systemic opiates on responses to inhaled capsaicin in humans, J. Appl. Physiol., 65, 1125, 10.1152/jappl.1988.65.3.1125
Barros MJ, 1991, Effect of changes in inspiratory flow rate on cough responses to inhaled capsaicin, Clin. Sci., 81, 539, 10.1042/cs0810539
Bascom R, 1991, Effect of intranasal capsaicin on symptoms and mediator release, J. Pharmacol. Exp. Ther., 259, 1323
Gosselin RE, 1976, Clinical Toxicology of Commercial Products
1971, Report of the Enquiry into the Medical and Toxicological Aspects of CS (Orthochlorobenzylidene malononitrile). Part II. Enquiry into Toxicological Aspects of CS and its use for Civil Purposes
1969, Report of the Enquiry into the Medical and Toxicological Aspects of CS (Orthochlorobenzylidene malononitrile). Part I. Enquiry into the Medical Situation following the use of CS in Londonderry on 13th and 14th August, 1969
Park S, 1972, Toxic effects of tear gas on an infant following prolonged exposure, Am. J. Dis. Child., 123, 245
Krapf R, 1981, Akute exposition durch CS‐rauchgas und linische beobachtungen, Schweiz. Med. Wochenschr., 11, 2056
GAO (United States General Accounting Office), 1989, Use of U.S. Manufactured Tear Gas in the Occupied Territories, GAO/NSIAD‐89–128
Physicians for Human Rights, 1988, The Casualties of Conflict: Medical Care and Human Rights in the West bank and Gaza Strip
Bandman AL, 1977, CR toxicology, Voen. Med. Zh., 3, 84
Ashton I, 1978, Acute effect of dibenz (b,f)‐1 : 4‐oxazepine aerosol upon the lung function of healthy young men, J. Physiol., 275, 85p
Stein AA, 1964, Chloroacetophenone (tear gas) poisoning: a clinico‐pathological report, J. Forens. Sci., 9, 374
Lawson WE, Report on the relation between concentration limit of tolerance for diphenylamine chloroarsine and the development of a continuous flow apparatus for testing, EACD 92, (Jan 1922)
Gongwer LE, 1958, The Comparative Effectiveness of Four Riot Control Agents