RhoGDIs Revisited: Novel Roles in Rho Regulation

Traffic - Tập 6 Số 11 - Trang 957-966 - 2005
Estelle Dransart1, Birgitta Olofsson1, Jacqueline Cherfils1
1Laboratoire d'Enzymologie et Biochimie Structurales, CNRS, Avenue de la Terrasse, 91198 Gif‐sur‐Yvette, France

Tóm tắt

Small GTP‐binding proteins of the Rho/Rac/Cdc42 family combine their GDP/GTP cycle, regulated by guanine nucleotide‐exchange factors and GTPase‐activating proteins, to a cytosol/membrane cycle, regulated by guanine nucleotide dissociation inhibitors (rhoGDIs). RhoGDIs are endowed with dual functions in the cytosol where they form soluble complexes with geranylgeranylated GDP‐bound Rho proteins and at membrane interfaces where they monitor the delivery and extraction of Rho proteins to/from their site of action. They have little diversity compared with other Rho protein regulators and therefore have been regarded mostly as housekeeping regulators that distribute Rho proteins equally to any membranes. Recently, acquired data show that rhoGDIs, by interacting with candidate receptors/displacement factors or by phosphorylation, may in fact have active contributions to targeting Rho proteins to specific subcellular membranes and signaling pathways. In addition, the GDP/GTP and membrane/cytosol cycles can be uncoupled in certain cases, with Rho proteins either escaping the membrane/cytosol cycle or being regulated by rhoGDIs in their GTP‐bound form. Here, we survey recent structure‐function relationships and cellular studies on rhoGDIs and revisit their classical housekeeping role into novel and more specific functions. We also review their involvement in diseases.

Từ khóa


Tài liệu tham khảo

10.1016/S0898-6568(98)00063-1

Fukumoto Y, 1990, Molecular cloning and characterization of a novel type of regulatory protein (GDI) for the Rho proteins, ras p21‐like small GTP‐binding proteins, Oncogene, 5, 1321

Leonard D, 1992, The identification and characterization of a GDP‐dissociation inhibitor (GDI) for the Cdc42Hs protein, J Biol Chem, 267, 22860, 10.1016/S0021-9258(18)50026-0

10.1073/pnas.90.4.1479

10.1016/S0014-5793(98)00020-9

10.1074/jbc.271.48.30366

10.1006/geno.1998.5482

10.1034/j.1600-0854.2002.30504.x

10.1016/S0969-2126(97)00218-9

10.1006/jmbi.2000.4262

10.1107/S090744490201394X

10.1107/S0907444903026271

10.1016/S0092-8674(00)80670-4

10.1021/bi010288k

10.1038/nrm1589

10.1021/bi982198u

10.1021/bi010289c

10.1074/jbc.M409741200

10.1038/72392

10.1016/S0021-9258(17)41757-1

10.1021/bi049630u

10.1074/jbc.M210412200

10.1038/nrm1587

10.1111/j.1365-2567.2004.01882.x

10.1038/sj.onc.1201874

10.1038/sj.onc.1202871

10.1038/nn1045

10.1523/JNEUROSCI.4436-04.2005

10.1126/science.1092571

10.1038/ncb759

10.1016/S0014-5793(00)01121-2

10.1074/jbc.M204299200

10.1007/s00294-004-0505-9

10.1042/bj3610243

Tamma G, 2003, cAMP‐induced AQP2 translocation is associated with RhoA inhibition through RhoA phosphorylation and interaction with RhoGDI, J Cell Sci, 116, 1519, 10.1242/jcs.00355

10.1074/jbc.M213066200

10.1074/jbc.M101927200

10.1016/j.molcel.2004.05.019

10.1107/S090744490100556X

10.1038/sj.onc.1202921

Gibson RM, 2001, RhoGDI‐binding‐defective mutant of Cdc42Hs targets to membranes and activates filopodia formation but does not cycle with the cytosol of mammalian cells, Biochem J, 359, 285, 10.1042/bj3590285

10.1042/BJ20030979

10.1016/S0960-9822(03)00613-4

10.1091/mbc.E03-04-0254

10.1002/j.1460-2075.1993.tb05840.x

10.1002/j.1460-2075.1996.tb00383.x

10.1074/jbc.M000753200

10.1006/bbrc.2000.4194

10.1038/35075620

10.1161/01.RES.0000170084.88780.ea

10.1038/sj.emboj.7600612

10.1002/1096-8628(20001023)94:5<367::AID-AJMG4>3.0.CO;2-I

Pacaud P, 2005, Rho proteins and vascular diseases, Arch Mal Coeur Vaiss, 98, 249

10.1038/nrc725

10.1038/nrmicro1150

10.1038/487

10.1074/jbc.M301915200

10.1074/jbc.274.41.29050

10.1074/jbc.M303349200

10.1074/jbc.M406493200

MacKeigan JP, 2003, Proteomic profiling drug‐induced apoptosis in non‐small cell lung carcinoma: identification RS/DJ‐1 RhoGDIalpha, Cancer Res, 63, 6928

10.1016/S0165-4608(01)00386-7

10.1038/labinvest.3700057

Jiang WG, 2003, Prognostic value of rho GTPases and rho guanine nucleotide dissociation inhibitors in human breast cancers, Clin Cancer Res, 9, 6432

10.1023/A:1011819621859

10.1038/sj.onc.1203621

10.1074/jbc.M308215200

10.1038/sj.onc.1208182

10.1016/j.tips.2005.01.008

Thông tin
Thông tin xuất bản

Traffic

Tập 6 Số 11

957-966

Thông tin tác giả