Rho GTPases and the Actin Cytoskeleton

American Association for the Advancement of Science (AAAS) - Tập 279 Số 5350 - Trang 509-514 - 1998
Alan Hall1
1The author is at the Medical Research Council Laboratory for Molecular Cell Biology, Cancer Research Campaign Oncogene and Signal Transduction Group, University College London, Gower Street, London WC1E 6BT, UK.

Tóm tắt

The actin cytoskeleton mediates a variety of essential biological functions in all eukaryotic cells. In addition to providing a structural framework around which cell shape and polarity are defined, its dynamic properties provide the driving force for cells to move and to divide. Understanding the biochemical mechanisms that control the organization of actin is thus a major goal of contemporary cell biology, with implications for health and disease. Members of the Rho family of small guanosine triphosphatases have emerged as key regulators of the actin cytoskeleton, and furthermore, through their interaction with multiple target proteins, they ensure coordinated control of other cellular activities such as gene transcription and adhesion.

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I would like to thank the Cancer Research Campaign (United Kingdom) The Wellcome Trust (United Kingdom) and the Medical Research Council (United Kingdom) for their financial support. I thank D. Mackay and C. Nobes for critical reading of this manuscript and C. Nobes D. Bray V. Braga and D. Mackay for help with the figures.