Rheological Characterization of Vocal Folds after Injection Augmentation in a Preliminary Animal Study

Journal of Bioactive and Compatible Polymers - Tập 19 Số 4 - Trang 331-341 - 2004
Assunta Borzacchiello1, Laura Mayol1, Luigi Ambrosio1, Ola Gärskog2, Åke Dahlqvist2
1Institute of Composite and Biomedical Materials, CNR and CRIB, University of Naples, Federico II, Piazzale Tecchio 80, 80125 Napoli,
2Department of Otorhinolaryngology, University Hospital, University of Umea, Sweden

Tóm tắt

The investigation of vocal folds viscoelastic properties in an animal model (rabbit) after injection of various augmentation substances, 6 months after injection, is reported. The injected materials were: hyaluronan-based materials (Hylan B gel and Deflux®), cross-linked collagen (Zyplast®) and polytetrafluoroethylene (Teflon®). Rheological properties of the augmentation substances were also evaluated. The results from these animal experiments indicate that the viscoelastic properties of the vocal folds injected with Deflux®, Zyplast® and Hylan B gel are similar to the healthy vocal folds (non-injected samples) used as control, thus demonstrating that these materials are good candidates for further studies aimed at restoring/preserving the vibratory capacity of the vocal folds with injection treatment in glottal insufficiency.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Bioactive and Compatible Polymers

Tập 19 Số 4

331-341

Thông tin tác giả