Revisiting therapeutic and toxicological fingerprints of milk-derived bioactive peptides: An overview
Tóm tắt
Từ khóa
Tài liệu tham khảo
Abdel-Hamid, 2017, Angiotensin-I converting enzyme inhibitory activity and antioxidant capacity of bioactive peptides derived from enzymatic hydrolysis of buffalo milk proteins, International Dairy Journal, 66, 91, 10.1016/j.idairyj.2016.11.006
Abdel-Hamid, 2019, The biological activity of fermented milk produced by Lactobacillus casei ATCC 393 during cold storage, International Dairy Journal, 91, 1, 10.1016/j.idairyj.2018.12.007
Abdel-Hamid, 2020, Camel milk whey hydrolysate inhibits growth and biofilm formation of Pseudomonas aeruginosa PAO1 and methicillin-resistant Staphylococcus aureus, Food Control, 111, 107056, 10.1016/j.foodcont.2019.107056
Aguilar-Toala, 2017, Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains, Journal of Dairy Science, 100, 65, 10.3168/jds.2016-11846
Ahn, 2009, Angiotensin-I converting enzyme (ACE) inhibitory peptides from whey fermented by Lactobacillus species, Journal of Food Biochemistry, 33, 587, 10.1111/j.1745-4514.2009.00239.x
Aihara, 2009, Casein-derived tripeptide, Val-Pro-Pro (VPP), modulates monocyte adhesion to vascular endothelium, Journal of Atherosclerosis and Thrombosis, 16, 594, 10.5551/jat.729
Aihara, 2005, Effect of powdered fermented milk with Lactobacillus helveticus on subjects with high-normal blood pressure or mild hypertension, Journal of the American College of Nutrition, 24, 257, 10.1080/07315724.2005.10719473
Akalın, 2014, Dairy-derived antimicrobial peptides: Action mechanisms, pharmaceutical uses and production proposals, Trends in Food Science & Technology, 36, 79, 10.1016/j.tifs.2014.01.002
Akazawa, 2018, Lactotripeptide ingestion increases cerebral blood flow velocity in middle-aged and older adults, Nutrition Research, 53, 61, 10.1016/j.nutres.2018.03.009
Altmann, 2016, Generation and identification of anti-inflammatory peptides from bovine β-casein using enzyme preparations from cod and hog, Journal of the Science of Food and Agriculture, 96, 868, 10.1002/jsfa.7159
Aluko, 2019, Food protein-derived renin-inhibitory peptides: In vitro and in vivo properties, Journal of Food Biochemistry, 43, 12648, 10.1111/jfbc.12648
Alvarez-Ordonez, 2013, Structure-activity relationship of synthetic variants of the milk-derived antimicrobial peptide αs2-casein f (183–207), Applied and Environmental Microbiology, 79, 5179, 10.1128/AEM.01394-13
Anadon, 2010, Acute and repeated dose (4 weeks) oral toxicity studies of two antihypertensive peptides, RYLGY and AYFYPEL, that correspond to fragments (90-94) and (143-149) from αS1-casein, Food and Chemical Toxicology, 48, 1836, 10.1016/j.fct.2010.04.016
Arias, 2017, Anticancer activities of bovine and human lactoferricin-derived peptides, Biochemistry and Cell Biology, 95, 91, 10.1139/bcb-2016-0175
Artym, 2013, Milk-derived proteins and peptides in clinical trials, Postępy Higieny i Medycyny Doświadczalnej, 67, 800, 10.5604/17322693.1061635
Ashar, 2004, Fermented milk containing ACE-inhibitory peptides reduces blood pressure in middle aged hypertensive subjects, Milchwissenschaft, 59, 363
Aslam, 2020, Unravelled facets of milk-derived opioid peptides: A focus on gut physiology, fractures and obesity, International Journal of Food Sciences & Nutrition, 71, 36, 10.1080/09637486.2019.1614540
Athira, 2015, Production and characterization of whey protein hydrolysate having antioxidant activity from cheese whey, Journal of the Science of Food and Agriculture, 95, 2908, 10.1002/jsfa.7032
Ayyash, 2017, In vitro investigation of anticancer and ACE inhibiting activity, α-amylase and α-glucosidase inhibition, and antioxidant activity of camel milk fermented with camel milk probiotic: A comparative study with fermented bovine milk, Food Chemistry, 239, 588, 10.1016/j.foodchem.2017.06.149
Bamdad, 2017, Anti-inflammatory and antioxidant properties of casein hydrolysate produced using high hydrostatic pressure combined with proteolytic enzymes, Molecules, 22, 609, 10.3390/molecules22040609
Basilicata, 2018, Peptidome profiles and bioactivity elucidation of buffalo-milk dairy products after gastrointestinal digestion, Food Research International, 105, 1003, 10.1016/j.foodres.2017.12.038
Bassan, 2015, Buffalo cheese whey proteins, identification of a 24 kDa protein and characterization of their hydrolysates: In vitro gastrointestinal digestion, PloS One, 10, 10.1371/journal.pone.0139550
Bellamy, 1994, Antifungal properties of lactoferricin-B, a peptide derived from the N‐terminal region of bovine lactoferrin, Letters in Applied Microbiology, 18, 230, 10.1111/j.1472-765X.1994.tb00854.x
Beltran-Barrientos, 2018, Mechanistic pathways underlying the antihypertensive effect of fermented milk with Lactococcus lactis NRRL B-50571 in spontaneously hypertensive rats, Nutrients, 10, 262, 10.3390/nu10030262
Benkerroum, 2010, Antimicrobial peptides generated from milk proteins: A survey and prospects for application in the food industry: A review, International Journal of Dairy Technology, 63, 320, 10.1111/j.1471-0307.2010.00584.x
Blanco‐Miguez, 2016, From amino acid sequence to bioactivity: The biomedical potential of antitumor peptides, Protein Science, 25, 1084, 10.1002/pro.2927
Boutrou, 2015, On the trail of milk bioactive peptides in human and animal intestinal tracts during digestion: A review, Dairy Science & Technology, 95, 815, 10.1007/s13594-015-0210-0
Brouwer, 2011, Discovery and development of a synthetic peptide derived from lactoferrin for clinical use, Peptides, 32, 1953, 10.1016/j.peptides.2011.07.017
Buendia, 2018, Long-term yogurt consumption and risk of incident hypertension in adults, Journal of Hypertension, 36, 1671, 10.1097/HJH.0000000000001737
Buttar, 2017
Caetano-Silva, 2015, Iron binding peptides from whey protein hydrolysates: Evaluation, isolation and sequencing by LC-MS/MS, Food Research International, 71, 132139, 10.1016/j.foodres.2015.01.008
Carter, 2014, Side effects of commonly prescribed analgesic medications, Physical Medicine and Rehabilitation Clinics of North America, 25, 457, 10.1016/j.pmr.2014.01.007
Chakrabarti, 2014, Food-derived bioactive peptides on inflammation and oxidative stress, BioMed Research International, 2014, 10.1155/2014/608979
Chakrabarti, 2015, Milk-derived tripeptides IPP (Ile-Pro- Pro) and VPP (Val-Pro- Pro) promote adipocyte differentiation and inhibit inflammation in 3T3-F442A cells, PloS One, 10, 10.1371/journal.pone.0117492
Chaud, 2002, Iron derivatives from casein hydrolysates as a potential source in the treatment of iron deficiency, Journal of Agricultural and Food Chemistry, 50, 871877, 10.1021/jf0111312
Chen, 1995, Structural analysis of antioxidative peptides from soybean β-conglycinin, Journal of Agricultural and Food Chemistry, 43, 574, 10.1021/jf00051a004
Cheung, 1980, Binding of peptide substrates and inhibitors of angiotensin-converting enzyme. Importance of the COOH-terminal dipeptide sequence, Journal of Biological Chemistry, 255, 401, 10.1016/S0021-9258(19)86187-2
Chrysant, 2013, An update on the cardiovascular pleiotropic effects of milk and milk products, Journal of Clinical Hypertension, 15, 503, 10.1111/jch.12110
Cicero, 2016, Potential role of bioactive peptides in prevention and treatment of chronic diseases: A narrative review, British Journal of Pharmacology, 174, 1378, 10.1111/bph.13608
Cotarleț, 2019, Colostrum-derived bioactive peptides obtained by fermentation with kefir grains enriched with selected yeasts, The annals of the university dunarea de jos of galati. Fascicle VI - Food Technology, 43, 54
Cui, 2020, A novel endogenous antimicrobial peptide CAMP211-225 derived from casein in human milk, Food and Function, 11, 2291, 10.1039/C9FO02813G
Daliri, 2018, Antihypertensive peptides from whey proteins fermented by lactic acid bacteria, Food Science and Biotechnology, 27, 1781, 10.1007/s10068-018-0423-0
Damiens, 1999, Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells, Journal of Cellular Biochemistry, 74, 486, 10.1002/(SICI)1097-4644(19990901)74:3<486::AID-JCB16>3.0.CO;2-6
De Brito, 2018, Peptide vaccines for leishmaniasis, Frontiers in Immunology, 9, 1043, 10.3389/fimmu.2018.01043
De Gobba, 2014, Antioxidant peptides from goat milk protein fractions hydrolyzed by two commercial proteases, International Dairy Journal, 39, 28, 10.1016/j.idairyj.2014.03.015
De Gobba, 2014, Bioactive peptides from caseins released by cold active proteolytic enzymes from Arsukibacterium ikkense, Food Chemistry, 165, 205, 10.1016/j.foodchem.2014.05.082
De Mejia, 2010, The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells, Cancer and Metastasis Reviews, 29, 511, 10.1007/s10555-010-9241-4
Del Mar Contreras, 2011, Production of antioxidant hydrolysates from a whey protein concentrate with thermolysin: Optimization by response surface methodology, Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology, 44, 9, 10.1016/j.lwt.2010.06.017
Delshadian, 2018, Optimisation of experimental conditions for binding of divalent iron to bioactive casein phosphopeptides, International Journal of Food Science and Technology, 53, 784, 10.1111/ijfs.13654
Deng, 2013, Lactotransferrin acts as a tumor suppressor in nasopharyngeal carcinoma by repressing AKT through multiple mechanisms, Oncogene, 32, 4273, 10.1038/onc.2012.434
Dent, 2007, A 90-day subchronic toxicity study and reproductive toxicity studies on ACE inhibiting lactotripeptide, Food and Chemical Toxicology, 45, 1468, 10.1016/j.fct.2007.02.006
Dong, 2013, Effect of probiotic fermented milk on blood pressure: A meta-analysis of randomized controlled trials, British Journal of Nutrition, 110, 1188, 10.1017/S0007114513001712
Doorten, 2009, Safety evaluation of an IPP tripeptide-containing milk protein hydrolysate, Food and Chemical Toxicology, 47, 55, 10.1016/j.fct.2008.10.001
Dziuba, 2014, New milk protein-derived peptides with potential antimicrobial activity: An approach based on bioinformatic studies, International Journal of Molecular Sciences, 15, 14531, 10.3390/ijms150814531
El-Sayed, 2016, In vivo antidiabetic and biological activities of milk protein and milk protein hydrolyaste, Advanced Dairy Research, 4, 2
Elfahri, 2018
Eliassen, 2006, The antimicrobial peptide, lactoferricin-B, is cytotoxic to neuroblastoma cells in vitro and inhibits xenograft growth in vivo, International Journal of Cancer, 119, 493, 10.1002/ijc.21886
Engberink, 2009, Inverse association between dairy intake and hypertension: The Rotterdam Study, American Journal of Clinical Nutrition, 89, 1877, 10.3945/ajcn.2008.27064
Espinoza, 2020, Production of bioactive peptides from bovine colostrum whey using enzymatic hydrolysis, Revista Mexicana de Ingenieria Quimica, 19, 1
Fajardo-Espinoza, 2020, Production of bioactive peptides from bovine colostrum whey using enzymatic hydrolysis, Revista Mexicana de Ingenieria Quimica, 19, 1
Fan, 2019, Isolation and identification of novel casein-derived bioactive peptides and potential functions in fermented casein with Lactobacillus helveticus, Food Science and Human Wellness, 8, 156, 10.1016/j.fshw.2019.03.010
Farnaud, 2003, Lactoferrin: A multifunctional protein with antimicrobial properties, Molecular Immunology, 40, 395, 10.1016/S0161-5890(03)00152-4
Fernandes, 2017, The antifungal activity of lactoferrin and its derived peptides: Mechanisms of action and synergy with drugs against fungal pathogens, Frontiers in Microbiology, 8, 2, 10.3389/fmicb.2017.00002
Fernandez-Tome, 2016, Novel peptides derived from αS1-casein with opioid activity and mucin stimulatory effect on HT29-MTX cells, Journal of Functional Foods, 25, 466, 10.1016/j.jff.2016.06.023
FitzGerald, 2004, Hypotensive peptides from milk proteins, Journal of Nutrition, 134, 980, 10.1093/jn/134.4.980S
Freiburghaus, 2009, Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line, Journal of Dairy Science, 92, 2477, 10.3168/jds.2008-1851
Frid, 2005, Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in type-2 diabetic subjects, American Journal of Clinical Nutrition, 82, 69, 10.1093/ajcn/82.1.69
Furukawa, 2012, Cyclic dipeptides show potency for scavenging radicals, Bioorganic & Medicinal Chemistry, 20, 2002, 10.1016/j.bmc.2012.01.050
Gagnaire, 2001, Peptides identified during Emmental cheese ripening: Origin and proteolytic systems involved, Journal of Agricultural and Food Chemistry, 49, 4402, 10.1021/jf000895z
Garcia-Tejedor, 2013, Dairy yeasts produce milk protein-derived antihypertensive hydrolysates, Food Research International, 53, 203, 10.1016/j.foodres.2013.05.005
Garcia-Tejedor, 2015, Novel antihypertensive lactoferrin-derived peptides produced by Kluyveromyces marxianus: Gastrointestinal stability profile and in vivo angiotensin-I converting enzyme (ACE) inhibition, Journal of Agricultural and Food Chemistry, 62, 1609, 10.1021/jf4053868
Gaspar‐Pintiliescu, 2020, Angiotensin-converting enzyme inhibition, antioxidant activity and cytotoxicity of bioactive peptides from fermented bovine colostrum, International Journal of Dairy Technology, 73, 108, 10.1111/1471-0307.12659
Gautam, 2014, Hemolytik: A database of experimentally determined hemolytic and non-hemolytic peptides, Nucleic Acids Research, 42, 444, 10.1093/nar/gkt1008
Gleeson, 2015, Stability, toxicity and intestinal permeation enhancement of two food-derived antihypertensive tripeptides, Ile-Pro-Pro and Leu-Lys-Pro, Peptides, 71, 1, 10.1016/j.peptides.2015.05.009
Gnasegaran, 2017, Process development for bioactive peptide production, Food Bioactives, 91, 10.1007/978-3-319-51639-4_4
Gobbetti, 2004, Angiotensin-I converting enzyme-inhibitory and antimicrobial bioactive peptides, International Journal of Dairy Technology, 57, 172, 10.1111/j.1471-0307.2004.00139.x
Gobbetti, 2007, Bioactive peptides in dairy products, 489
Guha, 2018, Structural features of food derived bioactive peptides with anti‐inflammatory activity: A brief review, Journal of Food Biochemistry, 43, 12531, 10.1111/jfbc.12531
Guinane, 2015, Generation of the antimicrobial peptide caseicin-A from casein by hydrolysis with thermolysin enzymes, International Dairy Journal, 49, 1, 10.1016/j.idairyj.2015.04.001
Guo, 2019, Production and transepithelial transportation of angiotensin-I converting enzyme (ACE) inhibitory peptides from whey protein hydrolyzed by immobilized Lactobacillus helveticus proteinase, Journal of Dairy Science, 102, 961, 10.3168/jds.2018-14899
Gupta, 2010, Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals, Cancer and Metastasis Reviews, 29, 405, 10.1007/s10555-010-9235-2
Gupta, 2008
Gutierrez, 2016, Gonadotoxic effects of busulfan in two strains of mice, Reproductive Toxicology, 59, 31, 10.1016/j.reprotox.2015.09.002
Hafeez, 2014, Strategies of producing bioactive peptides from milk proteins to functionalize fermented milk products, Food Research International, 63, 71, 10.1016/j.foodres.2014.06.002
Hatzoglou, 1996, Antiproliferative and receptor binding properties of α and β-casomorphins in the T47D human breast cancer cell line, European Journal of Pharmacology, 310, 217, 10.1016/0014-2999(96)00339-1
Haversen, 2002, Lactoferrin down-regulates the LPS-induced cytokine production in monocytic cells via NF-κB, Cellular Immunology, 220, 83, 10.1016/S0008-8749(03)00006-6
Hayes, 2009, Evaluation of an antimicrobial ingredient prepared from a Lactobacillus acidophilus casein fermentate against Enterobacter sakazakii, Journal of Food Protection, 72, 340, 10.4315/0362-028X-72.2.340
He, 2019, Optimization of fermentation conditions for the production of angiotensin-converting enzyme (ACE) inhibitory peptides from cow milk by Lactobacillus bulgaricus LB, Acta Universitatis Cibiniensis. Series E: Food Technology, 23, 19, 10.2478/aucft-2019-0003
Hernandez-Ledesma, 2005, Preparation of antioxidant enzymatic hydrolysates from α-lactalbumin and β-lactoglobulin. Identification of active peptides by HPLC-MS/MS, Journal of Agricultural and Food Chemistry, 53, 588, 10.1021/jf048626m
Hernandez-Ledesma, 2011, Antihypertensive peptides: Production, bioavailability and incorporation into foods, Advances in Colloid and Interface Science, 165, 23, 10.1016/j.cis.2010.11.001
Hernandez-Ledesma, 2017, Chemopreventive role of food-derived proteins and peptides: A review, Critical Reviews in Food Science and Nutrition, 57, 2358, 10.1080/10408398.2015.1057632
Hill, 1974, A rennin-sensitive bond in α and ß-casein, Journal of Dairy Research, 41, 147, 10.1017/S0022029900015028
Hirota, 2011, Milk casein-derived tripeptides, VPP and IPP induced NO production in cultured endothelial cells and endothelium-dependent relaxation of isolated aortic rings, Heart and Vessels, 26, 549, 10.1007/s00380-010-0096-y
Hoskin, 2008, Studies on anticancer activities of antimicrobial peptides, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1778, 357, 10.1016/j.bbamem.2007.11.008
Hou, 2018, Broad-spectrum antimicrobial activity and low cytotoxicity against human cells of a peptide derived from bovine αS1-casein, Molecules, 23, 1220, 10.3390/molecules23051220
Hussein, 2019, Toxicity study and blood pressure-lowering efficacy of whey protein concentrate hydrolysate in rat models, plus peptide characterization, Journal of Dairy Science, 103, 2053, 10.3168/jds.2019-17462
Ibrahim, 2017, Novel angiotensin-converting enzyme inhibitory peptides from caseins and whey proteins of goat milk, Journal of Advanced Research, 8, 63, 10.1016/j.jare.2016.12.002
Jafar, 2018, Camel whey protein hydrolysates displayed enhanced cholesteryl esterase and lipase inhibitory, antihypertensive and anti-haemolytic properties, Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology, 98, 212, 10.1016/j.lwt.2018.08.024
Jakubowicz, 2013, Biochemical and metabolic mechanisms by which dietary whey protein may combat obesity and type-2 diabetes, Journal of Nutritional Biochemistry, 24, 1, 10.1016/j.jnutbio.2012.07.008
Jarmołowska, 2019, Role of milk-derived opioid peptides and proline dipeptidyl peptidase-4 in autism spectrum disorders, Nutrients, 11, 87, 10.3390/nu11010087
Jiehui, 2014, Immunomodulating effects of casein-derived peptides QEPVL and QEPV on lymphocytes in vitro and in vivo, Food and Function, 5, 2061, 10.1039/C3FO60657K
Jin, 2016, Peptide profiling and the bioactivity character of yogurt in the simulated gastrointestinal digestion, Journal of Proteomics, 141, 24, 10.1016/j.jprot.2016.04.010
Jones, 1930, The bacterial growth inhibitor (lactenin) of milk, Journal of Experimental Medicine, 51, 327, 10.1084/jem.51.2.327
Jun, 2004, Purification and characterization of an antioxidative peptide from enzymatic hydrolysate of yellowfin sole (Limanda aspera) frame protein, European Food Research and Technology, 219, 20, 10.1007/s00217-004-0882-9
Kajimoto, 2001, Safety evaluation of excessive intake of the tablet containing “lactotripeptides (VPP, IPP)” on healthy volunteers, Journal of Nutrition and Food, 4, 37
Kamali, 2017, Antimicrobial peptides derived from milk: A review, Journal of Food Biosciences and Technology, 7, 49
Kampa, 1996, Identification of a novel opioid peptide (Tyr-Val-Pro-Phe-Pro) derived from human αS1-casein (αS1-casomorphin, and αS1-casomorphin amide), Biochemical Journal, 313, 903, 10.1042/bj3190903
Kapila, 2017
Khan, 2018, Toxicity of biologically active peptides and future safety aspects: An update, Current Drug Discovery Technologies, 15, 236, 10.2174/1570163815666180219112806
Kinariwala, 2019, Exploring the potentiality of Lactobacillus cultures on the production of milk-derived bioactive peptides with antidiabetic activity, International Journal of Peptide Research and Therapeutics, 1
Kliche, 2017, Screening for proteolytically active lactic acid bacteria and bioactivity of peptide hydrolysates obtained with selected strains, Applied Microbiology and Biotechnology, 101, 7621, 10.1007/s00253-017-8369-3
Korhonen, 2006, Bioactive peptides: Production and functionality, International Dairy Journal, 16, 945, 10.1016/j.idairyj.2005.10.012
Korhonen, 1998, Impact of processing on bioactive proteins and peptides, Trends in Food Science & Technology, 9, 307, 10.1016/S0924-2244(98)00054-5
Kreider, 2011, Bioactive properties and clinical safety of a novel milk protein peptide, Nutrition Journal, 10, 99, 10.1186/1475-2891-10-99
Kumar, 2013, Antioxidative effect of yak milk caseinates hydrolyzed with three different proteases, Veterinary World, 6, 799, 10.14202/vetworld.2013.799-802
Kumari, 2015, Effect of bioactive peptides derived from fermented whey based drink against food borne pathogens, International Journal of Current Microbiology and Applied Science, 4, 936
Kumar, 2017
Kvistgaard, 2014, Pre-clinical in vitro and in vivo safety evaluation of bovine whey derived osteopontin, Lacprodan® OPN-10, Food and Chemical Toxicology, 73, 59, 10.1016/j.fct.2014.07.026
Kwak, 2016, The soy peptide Phe-Leu-Val reduces TNFα-induced inflammatory response and insulin resistance in adipocytes, Journal of Medicinal Food, 19, 678, 10.1089/jmf.2016.3685
Lacroix, 2012, Dipeptidyl peptidase-IV inhibitory activity of dairy protein hydrolysates, International Dairy Journal, 25, 97, 10.1016/j.idairyj.2012.01.003
Lacroix, 2013, Inhibition of dipeptidyl peptidase (DPP)-IV and α-glucosidase activities by pepsin-treated whey proteins, Journal of Agricultural and Food Chemistry, 61, 7500, 10.1021/jf401000s
Lacroix, 2014, Isolation and characterization of peptides with dipeptidyl peptidase-IV inhibitory activity from pepsin-treated bovine whey proteins, Peptides, 54, 39, 10.1016/j.peptides.2014.01.002
Lacroix, 2016, Do whey protein-derived peptides have dual dipeptidyl-peptidase-IV and angiotensin-I converting enzyme inhibitory activities?, Journal of Functional Foods, 21, 87, 10.1016/j.jff.2015.11.038
Lahov, 1996, Antibacterial and immunostimulating casein-derived substances from milk: Casecidin, isracidin peptides, Food and Chemical Toxicology, 34, 131, 10.1016/0278-6915(95)00097-6
Lee, 2018, Dairy food consumption is associated with a lower risk of the metabolic syndrome and its components: A systematic review and meta-analysis, British Journal of Nutrition, 6, 1
Li, 2020, Formation of bioactive peptides during simulated gastrointestinal digestion is affected by αS1-casein polymorphism in buffalo milk, Food Chemistry, 313, 126159, 10.1016/j.foodchem.2020.126159
Li, 2013, Characterization of structure-antioxidant activity relationship of peptides in free radical systems using QSAR models: Key sequence positions and their amino acid properties, Journal of Theoretical Biology, 318, 29, 10.1016/j.jtbi.2012.10.029
Lin, 2012, Improving antioxidant activities of whey protein hydrolysates obtained by thermal preheat treatment of pepsin, trypsin, alcalase and flavourzyme, International Journal of Food Science and Technology, 47, 2045, 10.1111/j.1365-2621.2012.03068.x
Lin, 2018, Yak milk casein as potential precursor of angiotensin-I converting enzyme inhibitory peptides based on in silico proteolysis, Food Chemistry, 254, 340, 10.1016/j.foodchem.2018.02.051
Liu, 2020, Inhibitory effect of milk-derived peptide αS2-casein151-181 against spore-forming bacteria, International Dairy Journal, 104, 104651, 10.1016/j.idairyj.2020.104651
Li, 2019, Novel angiotensin converting enzyme inhibitory peptides from fermented bovine milk started by Lactobacillus helveticus KLDS. 31 and Lactobacillus casei KLDS. 105: Purification, identification and interaction mechanism, Frontiers in Microbiology, 10, 2643, 10.3389/fmicb.2019.02643
Luhovyy, 2007, Whey proteins in the regulation of food intake and satiety, Journal of the American College of Nutrition, 26, 704, 10.1080/07315724.2007.10719651
Madadlou, 2018, Bioactive whey peptide particles: An emerging class of nutraceutical carriers, Critical Reviews in Food Science and Nutrition, 58, 1468, 10.1080/10408398.2016.1264064
Mada, 2018, Casein-derived antioxidative peptide prevents oxidative stress-induced dysfunction in osteoblast cells, Pharma Nutrition, 6, 169, 10.1016/j.phanu.2018.07.001
Ma, 2016, Isolation and characterization of anti-inflammatory peptides derived from whey protein, Journal of Dairy Science, 99, 6902, 10.3168/jds.2016-11186
Malkoski, 2001, Kappacin, a novel antibacterial peptide from bovine milk, Antimicrobial Agents and Chemotherapy, 45, 2309, 10.1128/AAC.45.8.2309-2315.2001
Manzanares, 2015, Unraveling the mechanisms of action of lactoferrin-derived antihypertensive peptides: ACE inhibition and beyond, Food and Function, 6, 2440, 10.1039/C5FO00580A
Marcone, 2015, Milk-derived bioactive peptides inhibit human endothelial-monocyte interactions via PPAR-γ dependent regulation of NF-κB, Journal of Inflammation, 12, 1, 10.1186/s12950-014-0044-1
Martin, 2019, Effects of natural peptides from food proteins on angiotensin converting enzyme activity and hypertension, Critical Reviews in Food Science and Nutrition, 59, 1264, 10.1080/10408398.2017.1402750
McCann, 2006, Isolation and characterisation of a novel antibacterial peptide from bovine αS1-casein, International Dairy Journal, 16, 316, 10.1016/j.idairyj.2005.05.005
McDonnell, 2012, Inhibition of verocytotoxigenic Escherichia coli by antimicrobial peptides caseicin A and B and the factors affecting their antimicrobial activities, International Journal of Food Microbiology, 153, 260, 10.1016/j.ijfoodmicro.2011.10.001
McGrane, 2011, Dairy consumption, blood pressure, and risk of hypertension: An evidence-based review of recent literature, Current Cardiovascular Risk Reports, 5, 287, 10.1007/s12170-011-0181-5
Meignanalakshmi, 2013, Antibacterial activity of papain hydrolysates of buffalo milk whey protein against mastitis pathogens, International Journal of Pharma Bio Sciences, 4, 1133
Meisel, 2000, Opioid peptides encrypted in intact milk protein sequences, British Journal of Nutrition, 84, 27, 10.1017/S000711450000221X
Meisel, 2003, Bio-functional peptides from milk proteins: Mineral binding and cytomodulatory effects, Current Pharmaceutical Design, 9, 1289, 10.2174/1381612033454847
Mendes, 2019
Miclo, 2012, Variability of hydrolysis of β-, αS1-, and αS2-caseins by 10 strains of Streptococcus thermophilus and resulting bioactive peptides, Journal of Agricultural and Food Chemistry, 60, 554, 10.1021/jf202176d
Mierke, 1990, Morphiceptin analogs containing 2-aminocyclopentane carboxylic acid as a peptidomimetic for proline, International Journal of Peptide Research, 35, 34, 10.1111/j.1399-3011.1990.tb00718.x
Miralles, 2018, Critical review and perspectives on food-derived antihypertensive peptides, Journal of Agricultural and Food Chemistry, 66, 9384, 10.1021/acs.jafc.8b02603
Mishra, 2013, A novel antimicrobial peptide derived from modified N-terminal domain of bovine lactoferrin: Design, synthesis, activity against multidrug-resistant bacteria and Candida, Biochimica et Biophysica Acta (BBA) - Biomembranes, 1828, 677, 10.1016/j.bbamem.2012.09.021
Mizuno, 2005, Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): V. A 13-week toxicity study of tripeptides-containing casein hydrolysate in male and female rats, International Journal of Toxicology, 24, 41, 10.1080/10915810500259606
Mohanty, 2016, Milk- derived antimicrobial bioactive peptides: A review, International Journal of Food Properties, 19, 837, 10.1080/10942912.2015.1048356
Mohanty, 2016, Milk-derived bioactive peptides and their impact on human health - a review, Saudi Journal of Biological Sciences, 23, 577, 10.1016/j.sjbs.2015.06.005
Mojica, 2018, Black bean peptides inhibit glucose uptake in caco-2 adenocarcinoma cells by blocking the expression and translocation pathway of glucose transporters, Toxicology Reports, 5, 552, 10.1016/j.toxrep.2018.04.007
Nadkarni, 2014, Regulation of glucose homeostasis by GLP-1, Progress in Molecular Biology and Translational Science, 121, 23, 10.1016/B978-0-12-800101-1.00002-8
Nagaoka, 2001, Identification of novel hypocholesterolemic peptides derived from bovine milk β-lactoglobulin, Biochemical and Biophysical Research Communications, 281, 11, 10.1006/bbrc.2001.4298
Nagpal, 2011, Bioactive peptides derived from milk proteins and their health beneficial potentials: An update, Food and Function, 2, 18, 10.1039/C0FO00016G
Nakamura, 2005, Studies of the toxicological potential of tripeptides (L-valyl-L-prolyl-L-proline and L-isoleucyl-L-prolyl-L-proline): IV. Assessment of the repeated-dose toxicological potential of synthesized L-valyl-L-prolyl-L-proline in male and female rats and dogs, International Journal of Toxicology, 24, 25, 10.1080/10915810500259580
Nakamura, 2013, Milk-derived peptides, val-pro-pro and ile-pro-pro, attenuate atherosclerosis development in apolipoprotein-E deficient mice: A preliminary study, Journal of Medicinal Food, 16, 396, 10.1089/jmf.2012.2541
Nguyen, 2015, Formation and degradation of ß-casomorphins in dairy processing, Critical Reviews in Food Science and Nutrition, 55, 1955, 10.1080/10408398.2012.740102
Nielsen, 2017, Milk bioactive peptide database: A comprehensive database of milk protein-derived bioactive peptides and novel visualization, Food Chemistry, 232, 673, 10.1016/j.foodchem.2017.04.056
Nielsen, 2012, Effect of milk hydrolysates on inflammation markers and drug-induced transcriptional alterations in cell-based models, Journal of Animal Science, 90, 403, 10.2527/jas.53953
Nongonierma, 2019, Dipeptidyl peptidase IV (DPP-IV) inhibitory properties of a camel whey protein enriched hydrolysate preparation, Food Chemistry, 279, 70, 10.1016/j.foodchem.2018.11.142
Nongonierma, 2014, Susceptibility of milk protein-derived peptides to dipeptidyl peptidase IV (DPP-IV) hydrolysis, Food Chemistry, 145, 845, 10.1016/j.foodchem.2013.08.097
Nongonierma, 2015, Bioactive properties of milk proteins in humans: A review, Peptides, 73, 20, 10.1016/j.peptides.2015.08.009
Nongonierma, 2018, Enhancing bioactive peptide release and identification using targeted enzymatic hydrolysis of milk proteins, Analytical and Bioanalytical Chemistry, 410, 3407, 10.1007/s00216-017-0793-9
Nongonierma, 2013, Insulinotropic properties of whey protein hydrolysates and impact of peptide fractionation on insulinotropic response, International Dairy Journal, 32, 163, 10.1016/j.idairyj.2013.05.014
Norberg, 2011, Altering the composition of caseicins A and B as a means of determining the contribution of specific residues to antimicrobial activity, Applied and Environmental Microbiology, 77, 2496, 10.1128/AEM.02450-10
Nussberger, 2018, Lactotripeptides inhibiting ACE-1 elevate the plasma bradykinin concentration acutely in a placebo-controlled, double-blind, cross-over, 4-week trial in healthy volunteers, Pharmacology & Pharmacy, 9, 229, 10.4236/pp.2018.97017
O'Keeffe, 2017, Identification of angiotensin converting enzyme inhibitory and antioxidant peptides in a whey protein concentrate hydrolysate produced at semi-pilot scale, International Journal of Food Science and Technology, 52, 1751, 10.1111/ijfs.13448
Oecd, 1995
Oecd, 2008
Oecd, 2008
Oecd, 2018
Oseguera-Toledo, 2014, Proteins and bioactive peptides, Nutrafoods, 13, 147, 10.1007/s13749-014-0052-z
Otte, 2007, Angiotensin converting enzyme inhibitory activity of milk protein hydrolysates: Effects of substrate, enzyme and time of hydrolysis, International Dairy Journal, 17, 488, 10.1016/j.idairyj.2006.05.011
Oun, 2013, Encapsulation of cisplatin by cucurbit uril decreases the neurotoxic and cardiotoxic side effects of cisplatin, Toxicology Letters, S92, 10.1016/j.toxlet.2013.05.121
Panayotova, 2018, Production of ACE inhibitory peptides in milk fermented with selected lactic acid bacteria, Journal of Bioscience and Biotechnology, 7, 31
Parodi, 2007, A role for milk proteins and their peptides in cancer prevention, Current Pharmaceutical Design, 13, 813, 10.2174/138161207780363059
Peng, 2010, Reducing and radical-scavenging activities of whey protein hydrolysates prepared with alcalase, International Dairy Journal, 20, 360, 10.1016/j.idairyj.2009.11.019
Pepe, 2016, Antioxidant peptides released from gastrointestinal digestion of “stracchino” soft cheese: Characterization, in vitro intestinal protection and bioavailability, Journal of Functional Foods, 26, 494, 10.1016/j.jff.2016.08.021
Pepe, 2013, Potential anticarcinogenic peptides from bovine milk, Journal of Amino Acids, 2013, 10.1155/2013/939804
Perego, 2012, Casein phosphopeptides modulate proliferation and apoptosis in HT-29 cell line through their interaction with voltage-operated L-type calcium channels, Journal of Nutritional Biochemistry, 23, 808, 10.1016/j.jnutbio.2011.04.004
Phanturat, 2010, Use of pyloric caeca extract from bigeye snapper (Priacanthus macracanthus) for the production of gelatin hydrolysate with antioxidative activity, Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology, 43, 86, 10.1016/j.lwt.2009.06.010
Phillips, 2009
Pihlanto, 2006, Antioxidative peptides derived from milk proteins, International Dairy Journal, 16, 1306, 10.1016/j.idairyj.2006.06.005
Pihlanto, 2013, Lactic fermentation and bioactive peptides, 309
Pihlanto-Leppala, 2000, Bioactive peptides derived from bovine whey proteins: Opioid and ACE inhibitory peptides, Trends in Food Science & Technology, 11, 347, 10.1016/S0924-2244(01)00003-6
Pihlanto-Leppala, 1994, Opioid peptides produced by in vitro proteolysis of bovine caseins, International Dairy Journal, 4, 291, 10.1016/0958-6946(94)90028-0
Ponstein-Simarro, 2009, Safety evaluation of an IPP tripeptide-containing milk protein hydrolysate, Food and Chemical Toxicology, 47, 55, 10.1016/j.fct.2008.10.001
Poulin, 2005, Safety and efficacy of a milk-derived extract in the treatment of plaque psoriasis: An open-label study, Journal of Cutaneous Medicine and Surgery, 9, 271
Power, 2013, Antioxidative peptides: Enzymatic production, in vitro and in vivo antioxidant activity and potential applications of milk-derived antioxidative peptides, Amino Acids, 44, 797, 10.1007/s00726-012-1393-9
Pradhan, 2019, Comprehensive approaches for assessing the safety of probiotic bacteria, Food Control, 108, 106872, 10.1016/j.foodcont.2019.106872
Pripp, 2004, Quantitative structure-activity relationship modelling of ACE inhibitory peptides derived from milk proteins, European Food Research and Technology, 219, 579, 10.1007/s00217-004-1004-4
Raiston, 2012, A systematic review and meta-analysis of elevated blood pressure and consumption of dairy foods, Journal of Human Hypertension, 26, 3, 10.1038/jhh.2011.3
Rajapakse, 2005, Purification of a radical scavenging peptide from fermented mussel sauce and its antioxidant properties, Food Research International, 38, 175, 10.1016/j.foodres.2004.10.002
Rao, 2017, Safety assessment of nutraceuticals, Biology, Engineering, Medicine and Science Reports, 3, 70, 10.5530/bems.3.2.9
Raveschot, 2018, Production of bioactive peptides by Lactobacillus species: From gene to application, Frontiers in Microbiology, 9, 2354, 10.3389/fmicb.2018.02354
Reddi, 2012, Evaluation of allergenic response of milk bioactive peptides using mouse mast cell, Milchwissenschaft - Milk Science International, 67, 189
Righard, 2014, Enhanced levels of immunoreactive β-casomorphin-8 in milk of breastfeeding women with mastitis, Peptides, 51, 54, 10.1016/j.peptides.2013.10.027
Rojas-Ronquillo, 2012, Antithrombotic and angiotensin converting enzyme inhibitory properties of peptides released from bovine casein by Lactobacillus casei Shirota, International Dairy Journal, 26, 147, 10.1016/j.idairyj.2012.05.002
Roubille, 2013, Cardiovascular adverse effects of anti-inflammatory drugs, Anti-Inflammatory & Anti-allergy Agents in Medicinal Chemistry, 12, 55, 10.2174/1871523011312010008
Roudot‐Algaron, 1994, Phosptiopeptides from comte cheese: Nature and origin, Journal of Food Science, 59, 544, 10.1111/j.1365-2621.1994.tb05558.x
Rubak, 2020, Angiotensin-I converting enzyme inhibitory peptides in milk fermented by indigenous lactic acid bacteria, Veterinary World, 13, 345, 10.14202/vetworld.2020.345-353
Rutella, 2016, Survival and bioactivities of selected probiotic lactobacilli in yogurt fermentation and cold storage: New insights for developing a bi-functional dairy food, Food Microbiology, 60, 54, 10.1016/j.fm.2016.06.017
Sah, 2018, Antioxidative and antibacterial peptides derived from bovine milk proteins, Critical Reviews in Food Science and Nutrition, 58, 726, 10.1080/10408398.2016.1217825
Sanchez-Rivera, 2016, Peptide fragments from β-casein f (134-138), HLPLP, generated by the action of rat blood plasma peptidases show potent antihypertensive activity, Food Research International, 88, 348, 10.1016/j.foodres.2015.12.007
Schrimpf, 2018, Hinge-type dimerization of proteins by a tetracysteine peptide of high pairing specificity, Biochemistry, 57, 3658, 10.1021/acs.biochem.8b00475
Seppo, 2003, A fermented milk high in bioactive peptides has a blood pressure-lowering effect in hypertensive subjects, American Journal of Clinical Nutrition, 77, 326, 10.1093/ajcn/77.2.326
Serhan, 2005, Resolution of inflammation: The beginning programs the end, Nature Immunology, 6, 1191, 10.1038/ni1276
Shanmugam, 2015, Antioxidative peptide derived from enzymatic digestion of buffalo casein, International Dairy Journal, 42, 1, 10.1016/j.idairyj.2014.11.001
Shazly, 2017, Fractionation and identification of novel antioxidant peptides from buffalo and bovine casein hydrolysates, Food Chemistry, 232, 753, 10.1016/j.foodchem.2017.04.071
Shazly, 2019, Release of antioxidant peptides from buffalo and bovine caseins: Influence of proteases on antioxidant capacities, Food Chemistry, 274, 261, 10.1016/j.foodchem.2018.08.137
Shimizu, 2006, Dietary whey protein hydrolysate suppresses development of atopic dermatitis-like skin lesions induced by mite antigen in NC/Nga mice, Allergology International, 55, 185, 10.2332/allergolint.55.185
Siltari, 2017, Long-term feeding with bioactive tripeptides in aged hypertensive and normotensive rats: Special focus on blood pressure and bradykinin-induced vascular reactivity, Journal of Physiology & Pharmacology, 68, 407
Siltari, 2019, Milk and milk‐derived peptides combat against hypertension and vascular dysfunction: A review, International Journal of Food Science and Technology, 54, 1920, 10.1111/ijfs.14056
Silveira, 2013, Dipeptidyl peptidase-IV inhibitory peptides generated by tryptic hydrolysis of a whey protein concentrate rich in β-lactoglobulin, Food Chemistry, 141, 1072, 10.1016/j.foodchem.2013.03.056
Singh, 2018, In vitro stability of bioactive peptides derived from fermented soy milk against heat treatment, pH and gastrointestinal enzymes, Lebensmittel-Wissenschaft und -Technologie- Food Science and Technology, 91, 303, 10.1016/j.lwt.2018.01.066
Singh, 2014, Functional significance of bioactive peptides derived from soybean, Peptides, 54, 171, 10.1016/j.peptides.2014.01.022
Soleymanzadeh, 2019, Novel β-casein derived antioxidant and ACE inhibitory active peptide from camel milk fermented by Leuconostoc lactis PTCC1899: Identification and molecular docking, International Dairy Journal, 97, 201, 10.1016/j.idairyj.2019.05.012
Sowmya, 2019, Buffalo milk casein derived decapeptide (YQEPVLGPVR) having bifunctional anti-inflammatory and antioxidative features under cellular milieu, International Journal of Peptide Research and Therapeutics, 25, 623, 10.1007/s10989-018-9708-7
Sowmya, 2019, Antioxidative and anti-inflammatory potential with trans-epithelial transport of a buffalo casein-derived hexapeptide (YFYPQL), Food Bioscience, 28, 151, 10.1016/j.fbio.2019.02.003
Sowmya, 2018, Bio-accessible milk casein derived tripeptide (LLY) mediates overlapping anti-inflammatory and anti-oxidative effects under cellular (Caco-2) and in vivo milieu, Journal of Nutritional Biochemistry, 62, 167, 10.1016/j.jnutbio.2018.09.002
Suetsuna, 2000, Isolation and characterization of free radical scavenging activities peptides derived from casein, Journal of Nutritional Biochemistry, 11, 128, 10.1016/S0955-2863(99)00083-2
Sun, 2012, Iron-saturated bovine lactoferrin improves the chemotherapeutic effects of tamoxifen in the treatment of basal-like breast cancer in mice, BMC Cancer, 12, 591, 10.1186/1471-2407-12-591
Tang, 2015, An antimicrobial peptide screened from casein hydrolyzate by Saccharomyces cerevisiae cell membrane affinity method, Food Control, 50, 413, 10.1016/j.foodcont.2014.09.030
Tani, 1990, Isolation and characterization of opioid antagonist peptides derived from human lactoferrin, Agricultural & Biological Chemistry, 54, 1803
Tani, 1994, Serophin, an opioid peptide derived from serum albumin, 49
Tavares, 2011, Optimisation, by response surface methodology, of degree of hydrolysis and antioxidant and ACE inhibitory activities of whey protein hydrolysates obtained with cardoon extract, International Dairy Journal, 21, 926, 10.1016/j.idairyj.2011.05.013
Teschemacher, 1997, Milk protein-derived opioid receptor ligands, Peptide Science, 43, 99, 10.1002/(SICI)1097-0282(1997)43:2<99::AID-BIP3>3.0.CO;2-V
Tidona, 2009, Bioactive peptides in dairy products, Italian Journal of Animal Science, 8, 315, 10.4081/ijas.2009.315
Tonolo, 2020, Identification of new peptides from fermented milk showing antioxidant properties: Mechanism of action, Antioxidants, 9, 117, 10.3390/antiox9020117
Tonolo, 2019, Insight into antioxidant properties of milk-derived bioactive peptides in vitro and in a cellular model, Journal of Peptide Science, 25, 3162, 10.1002/psc.3162
Tulipano, 2011, Whey proteins as source of dipeptidyl dipeptidase-IV (dipeptidyl peptidase-4) inhibitors, Peptides, 32, 835, 10.1016/j.peptides.2011.01.002
Tu, 2018, Bioactive hydrolysates from casein: Generation, identification, and in silico toxicity and allergenicity prediction of peptides, Journal of the Science of Food and Agriculture, 98, 3416, 10.1002/jsfa.8854
Turkez, 2017, Genotoxicity testing: Progress and prospects for the next decade, Expert Opinion on Drug Metabolism and Toxicology, 13, 1089, 10.1080/17425255.2017.1375097
Turpeinen, 2012, A spread containing bioactive milk peptides Ile-Pro-Pro and Val-Pro-Pro, and plant sterols has antihypertensive and cholesterol-lowering effects, Food and Function, 3, 621, 10.1039/c2fo10286b
Uchida, 2011, Novel dipeptidyl peptidase-4 inhibiting peptide derived from β-lactoglobulin, Journal of Pharmacological Sciences, 117, 63, 10.1254/jphs.11089SC
Udechukwu, 2017, Influence of structural and surface properties of whey-derived peptides on zinc-chelating capacity, and in vitro gastric stability and bioaccessibility of the zinc-peptide complexes, Food Chemistry, 240, 1227, 10.1016/j.foodchem.2017.08.063
Uenishi, 2012, Isolation and identification of casein-derived dipeptidyl-peptidase 4 (DPP-4)-inhibitory peptide LPQNIPPL from gouda-type cheese and its effect on plasma glucose in rats, International Dairy Journal, 22, 24, 10.1016/j.idairyj.2011.08.002
Van Meijl, 2011, Low fat dairy consumption reduces systolic blood pressure, but does not improve other metabolic risk parameters in overweight and obese subjects, Nutrition, Metabolism, and Cardiovascular Diseases, 21, 355, 10.1016/j.numecd.2009.10.008
Van, 2016, High-resolution laser ablation-inductively coupled plasma-mass spectrometry imaging of cisplatin-induced nephrotoxic side effects, Analytica Chimica Acta, 945, 23, 10.1016/j.aca.2016.10.014
Varadhachary, 2004, Oral lactoferrin inhibits growth of established tumors and potentiates conventional chemotherapy, International Journal of Cancer, 111, 398, 10.1002/ijc.20271
Vaucher, 2010, Evaluation of the in vitro cytotoxicity of the antimicrobial peptide P34, Cell Biology International, 34, 317, 10.1042/CBI20090025
van der Velden, 2009, Safety and tolerability of the antimicrobial peptide human lactoferrin 1-11 (hLF1-11), BMC Medicine, 7, 44, 10.1186/1741-7015-7-44
Vij, 2014, Antimicrobial activity of casein fermentate of probiotic Lactobacillus spp, International Journal of Genetic Engineering and Biotechnology, 5, 201
Wada, 2014, Bioactive peptides derived from human milk proteins-mechanisms of action, Journal of Nutritional Biochemistry, 25, 503, 10.1016/j.jnutbio.2013.10.012
Wang, 2011, Resolvin D1 protects mice from LPS-induced acute lung injury, Pulmonary Pharmacology & Therapeutics, 24, 434, 10.1016/j.pupt.2011.04.001
Wang, 2020, Antibacterial activity of trypsin-hydrolyzed camel and cow whey and their fractions, Animals, 10, 337, 10.3390/ani10020337
Weatherspoon
Worringer, 2006, Health effects and technological features of caseinomacropeptide, International Dairy Journal, 16, 1324, 10.1016/j.idairyj.2006.06.012
Worsztynowicz, 2020, Integrated approach for obtaining bioactive peptides from whey proteins hydrolyzed using a new proteolytic lactic acid bacteria, Food Chemistry, 312, 126035, 10.1016/j.foodchem.2019.126035
Wu, 2006, Structural requirements of angiotensin-I converting enzyme inhibitory peptides: Quantitative structure-activity relationship study of di-and tripeptides, Journal of Agricultural and Food Chemistry, 54, 732, 10.1021/jf051263l
Wu, 2019, Angiotensin-converting enzyme inhibitory peptides from Lactobacillus delbrueckii QS306 fermented milk, Journal of Dairy Science, 102, 5913, 10.3168/jds.2018-15901
Yadav, 2015, Cheese whey: A potential resource to transform into bioprotein, functional/nutritional proteins and bioactive peptides, Biotechnology Advances, 33, 756, 10.1016/j.biotechadv.2015.07.002
Yamamoto, 2003, Biogenic peptides and their potential use, Current Pharmaceutical Design, 9, 1345, 10.2174/1381612033454801
Yamauchi, 2003, ß-lactotensin (HIRL) and neurotensin rapidly reduce serum cholesterol via NT2 receptor, Peptides, 24, 1955, 10.1016/j.peptides.2003.10.003
Yang, 2020, Effect of peptides synthesized from lactoferrin of buffalo milk on oxidative stress in kunming mice, Journal of Animal and Plant Sciences, 30, 65
Yan, 2013, Bovine lactoferricin-induced anti-inflammation is, in part, via up-regulation of interleukin-11 by secondary activation of STAT3 in human articular cartilage, Journal of Biological Chemistry, 288, 31655, 10.1074/jbc.M112.440420
Yasuda, 2001, Effect of large high intake of tablets containing “lactotripeptides (VPP, IPP)” on blood pressure, pulse rate, and clinical parameters in healthy volunteers, Journal of Nutrition and Food, 4, 63
Yin, 2012, β‐casomorphin‐7 cause decreasing in oxidative stress and inhibiting NF‐κB‐iNOS‐NO signal pathway in pancreas of diabetes rats, Journal of Food Science, 77, 278, 10.1111/j.1750-3841.2011.02577.x
Yin, 2010, Protective effect of β-casomorphin-7 on type-1 diabetes rats induced with streptozotocin, Peptides, 31, 1725, 10.1016/j.peptides.2010.05.016
Zambrowicz, 2013, Manufacturing of peptides showing biological activity, Amino Acids, 44, 315, 10.1007/s00726-012-1379-7
Zanutto, 2019, Production of milk peptides with antimicrobial and antioxidant properties through fungal proteases, Food Chemistry, 278, 823, 10.1016/j.foodchem.2018.11.119
Zhang, 2017, Antimicrobial activity and mechanism of the human milk-sourced peptide casein201, Biochemical and Biophysical Research Communications, 485, 698, 10.1016/j.bbrc.2017.02.108
Zhang, 2013, The protective effects of ß-casomorphin-7 against glucose-induced renal oxidative stress in vivo and in vitro, PloS One, 8, 63472, 10.1371/journal.pone.0063472
Zhang, 2015, Peptides derived from oats improve insulin sensitivity and lower blood glucose in streptozotocin-induced diabetic mice, Journal of Biomedical Sciences, 4, 1
Zhao, 2015, Isolation and identification of a whey protein-sourced calcium-binding tripeptide Tyr-Asp-Thr, International Dairy Journal, 40, 16, 10.1016/j.idairyj.2014.08.013
Zhao, 2016, Purification and identification of anti-inflammatory peptides derived from simulated gastrointestinal digests of velvet antler protein (Cervus elaphus Linnaeus), Journal of Food and Drug Analysis, 24, 376, 10.1016/j.jfda.2015.10.003
Zhuang, 2019, Expression of milk-derived angiotensin-I converting enzyme-inhibitory peptides in Lactococcus lactis, Food Biotechnology, 33, 142, 10.1080/08905436.2019.1571420