Review of the effects of manufactured nanoparticles on mammalian target organs
Tóm tắt
Nanotechnology had matured significantly during the last two decades as it has transitioned from bench top science to applied technology. Even though the issue of safety of nanotechnology has been raised nearly one decade ago, the rapid progress in development and use of nanomaterials has not yet been matched by toxicological investigations. Many recent studies have simply outlined the toxic effects of nanoparticles (NPs), but few have systematically addressed their potentially adverse biological effects on target organs. Some animal models have shown that NPs could be accumulated in various organs. These accumulations can access the vasculature and target other organs, resulting in a potential health risks. After the brief description of current knowledge on the wide applications of several common NPs, their applications and the toxicokinetics, this review focused on effects of NPs on organ functions and mammal health after acute or chronic exposure, and potential mechanisms of action. Due to their physical properties, the liver, kidneys and lung are the main target organs of NPs. Most of NPs show slight toxicity when exposed to animals, while certain toxic effects like oxidative stress generation, inflammation and DNA damage are commonly observed. The severity of NPs toxicity is dependent upon several factors, including exposure dose and administration, NPs chemistry, size, shape, agglomeration state, and electromagnetic properties, which could provide useful information necessary to control the toxicity of NPs. Finally, the safety evaluation of nanotoxicity was addressed.
Từ khóa
Tài liệu tham khảo
Almeida A., 2016, Hormonal and organ‐specific dysfunction induced by the interaction between titanium dioxide nanoparticles and salicylic acid in male mice, Journal of Applied Toxicology, 27, 425
Baek M., 2012, Pharmacokinetics, tissue distribution, and excretion of zinc oxide nanoparticles, International Journal of Nanomedicine, 7, 3081
Bao W., 2015, PLGA‐PLL‐PEG‐Tf‐based targeted nanoparticles drug delivery system enhance antitumor efficacy via intrinsic apoptosis pathway, Int J Nanomedicine, 10, 557
Bellusci M., 2014, Biodistribution and acute toxicity of a nanofluid containing manganese iron oxide nanoparticles produced by a mechanochemical process, International Journal of Nanomedicine, 9, 1919
Chen H., 2013, In Vivo Study of Spherical Gold Nanoparticles: Inflammatory Effects and Distribution in Mice, Plos One, 8, 10.1371/journal.pone.0058208
Choi S.‐J., 2014, Biokinetics of zinc oxide nanoparticles: Toxicokinetics, biological fates, and protein interaction, International Journal of Nanomedicine, 9, 261
Das Manandhar D. Krishna Y. Prasad T. Prajapati V. K. Basukala O. Aganja R. P. …Sundar S.(2014).Nanonization Increases the Antileishmanial Efficacy of Amphotericin B: An Ex Vivo Approach. InR.Adhikari &S.Thapa(Eds.) Infectious Diseases and Nanomedicine II(Vol. 808 pp. 77‐91). Springer India.
Jarrar B. M., 2014, Renal Histological Alterations Induced by 10 nm Gold Nanoparticles Toxicity in Relation with the Time of Exposure, Latin American Journal of Pharmacy, 33, 725
Kim Y.‐R., 2014, Toxicity of colloidal silica nanoparticles administered orally for 90 days in rats, International Journal of Nanomedicine, 9, 67
Kim Y.‐R., 2014, Toxicity of 100 nm zinc oxide nanoparticles: A report of 90‐day repeated oral administration in Sprague Dawley rats, International Journal of Nanomedicine, 9, 109
Kim Y.‐R., 2014, Organization of research team for nano‐associated safety assessment in effort to study nanotoxicology of zinc oxide and silica nanoparticles, International Journal of Nanomedicine, 9, 3
Korani M., 2013, Sub‐chronic Dermal Toxicity of Silver Nanoparticles in Guinea Pig: Special Emphasis to Heart, Bone and Kidney Toxicities, Iranian Journal of Pharmaceutical Research, 12, 511
Lee J. A., 2014, Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats, International Journal of Nanomedicine, 9, 251
Ryu H. J., 2014, Zinc oxide nanoparticles: A 90‐day repeated‐dose dermal toxicity study in rats, International Journal of Nanomedicine, 9, 137
Tiwari D. K., 2011, Bio‐distribution and toxicity assessment of intravenously injected anti‐HER2 antibody conjugated CdSe/ZnS quantum dots in Wistar rats, International Journal of Nanomedicine, 6, 463
Wang Y., 2014, Effects of TiO2 nanoparticles on antioxidant function and element content of liver and kidney tissues in young and adult rats. Journal of Peking University, Health Sciences, 46, 395