Review of Infant Feeding: Key Features of Breast Milk and Infant Formula

Nutrients - Tập 8 Số 5 - Trang 279
Camilia R. Martin1, Pei‐Ra Ling2, George L. Blackburn2
1Department of Neonatology and Division of Translational Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
2Department of Surgery, Feihe Nutrition Laboratory, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA

Tóm tắt

Mothers’ own milk is the best source of nutrition for nearly all infants. Beyond somatic growth, breast milk as a biologic fluid has a variety of other benefits, including modulation of postnatal intestinal function, immune ontogeny, and brain development. Although breastfeeding is highly recommended, breastfeeding may not always be possible, suitable or solely adequate. Infant formula is an industrially produced substitute for infant consumption. Infant formula attempts to mimic the nutritional composition of breast milk as closely as possible, and is based on cow’s milk or soymilk. A number of alternatives to cow’s milk-based formula also exist. In this article, we review the nutritional information of breast milk and infant formulas for better understanding of the importance of breastfeeding and the uses of infant formula from birth to 12 months of age when a substitute form of nutrition is required.

Từ khóa


Tài liệu tham khảo

Lessen, 2015, Position of the academy of nutrition and dietetics: Promoting and supporting breastfeeding, J. Acad. Nutr. Diet., 115, 444, 10.1016/j.jand.2014.12.014

Savino, 2013, Advances on human milk hormones and protection against obesity, Cell. Mol. Biol., 59, 89

Infant and Young Child Nutrition. Available online: http://apps.who.int/gb/archive/pdf_files/WHA55/ea5515.pdf.

Eidelman, 2012, Breastfeeding and the use of human milk, Pediatrics, 129, e827, 10.1542/peds.2011-3552

Kozhimannil, K.B., Jou, J., Attanasio, L.B., Joarnt, L.K., and McGovern, P. (2014). Medically complex pregnancies and early breastfeeding behaviors: A retrospective analysis. PLoS ONE, 9.

U.S. Food and Drug Administration Guidance for Industry. Demostration of the Quality Factor Reguirements Under 21 CFR 106.96 (i) for “Eligible Infant Formulas”, Available online: http//www.fda.gov/downloads/Food/Guidance Regulation/Guidance Documents Regulatory Information/UCM400136/pdf.

Institute of Medicine of the National Academics (2004). Infant Formula: Evaluating The Safety of New Ingredients, The National Academics Press.

Stevens, 2009, A history of infant feeding, J. Perinat. Educ., 18, 32, 10.1624/105812409X426314

Gura, 2014, Nature’s first functional food, Science, 345, 747, 10.1126/science.345.6198.747

Walker, 2013, Initial intestinal colonization in the human infant and immune homeostasis, Ann. Nutr. Metab., 63, 8, 10.1159/000354907

Guo, M. (2014). Manufacturing Technology, Elsevier.

Jackson, 2004, A multinational study of α-lactalbumin concentrtions in human milk, J. Nutr. Biochem., 15, 517, 10.1016/j.jnutbio.2003.10.009

Koletzko, B., Poinderxter, B., and Uauy, R. (2014). Nutritional Care of Preterm Infants: Scientific Basis and Practical Guidelines, Karger Medical and Scientific Publishers.

Gros, 1981, Composition of breast milk rom mothers of preterm infants, Pediatrics, 68, 490, 10.1542/peds.68.4.490

Lonnerdal, 2003, Nutritonal and physiologic significance of human milk proteins, Am. J. Clin. Nutr., 77, 1537S, 10.1093/ajcn/77.6.1537S

Zhang, 2013, Amino acid profiles in term and preterm human milk through lactation: A systemic Review, Nutrients, 5, 4800, 10.3390/nu5124800

Agostoni, 2000, Free glutamine and glutamic acid in casien in human milk through a three-month lactation period, J. Pediatry. Gastroenterol. Nutr., 31, 508

Bonigla, 2003, Influence of maternal protein intake on nitrogen fractions of human milk, Int. J. Vitam. Nutr. Res., 76, 447, 10.1024/0300-9831.73.6.447

Herrera, 2002, Implication of dietary fatty acids during pregnancy on placental, fetal and postnatal development—A review, Placenta, 23, S9, 10.1053/plac.2002.0771

Joardar, 2006, Docosahexaeoic acid facilitates cell maturation and beta-adrenergic transmission in astrocytes, J. Lipid Res., 47, 571, 10.1194/jlr.M500415-JLR200

Szabo, 2010, Fatty aicd profile comparisons in human milk sampled from the same mothers at the sixth week and the sixth month of lactation, J. Pediatr. Gastroenteral. Nutr., 50, 316, 10.1097/MPG.0b013e3181a9f944

Villapando, 2001, Contribution of dietary and newly formed arachidonic acid to human milk lipids in women eating a low-fat diet, Am. J. Clin. Nutr., 74, 242, 10.1093/ajcn/74.2.242

Weseler, 2008, Dietary arachidonic acid dose-dependency increases with arachidonic acid concetration in human milk, J. Nutr., 138, 2190, 10.3945/jn.108.089318

Makrides, 1996, Effect of maternal docosahexaenoic acid (DHA) suppplementation on breast milk composition, Eur. J. Clin. Nutr., 50, 352

Fleith, 2005, Dietary PUFA for preterm and term infants. review of clinical studies, Crit. Rev. Food Sci. Nutr., 45, 205, 10.1080/10408690590956378

Innis, 2014, Impact of maternal diet on human milk composition and neurological development of infants, Am. J. Clin. Nutr., 99, 734S, 10.3945/ajcn.113.072595

Martin, 2011, Decreased postnatal docsahexaenoic and arachidonic acid blood levels in premature infants are associated with neonatal morbidities, J. Pediatr., 159, 743, 10.1016/j.jpeds.2011.04.039

Formerly Director of Medical Service Ghana; at present Inter-Regional coordinator of the World Hunger Program (1980). WHO/UNICEF meeting on infant and young child feeding. J. Nurse Medwifery, 25, 31–38.

Lonnerdal, 2012, Preclinical assessment of infant formula, Am. Nutr. Metab., 60, 196, 10.1159/000338209

Safe Preparation, Storage and Handling of Powdered Infant Formula Guidelines. Available online: http://www.who.int/foodsafety/publication/micro/pit_quideline.pdf.

Michael, M. SPX Benefitting from Increased Global Demand for Powdered Infant Formula. Available online: http://www.spx.com/en/literature/articles/apac-infant-formula.

Renfrew, E. 7% Growth for $50 Billion Global Infant Nutrition Market. Available online: http://www.zenithinternational.com/articles/1355?7%25+growth+for+%2450+Billion+global+infant+nutrition+market.

U.S. National Library of Medicine Infant Formulas—Overview, Available online: https://www.nlm.nih.gov/medlineplus/ency/article/002447.htm.

Koletzko, 2005, Global standard for the composition of infant formula: Recommendations of an ESPGHAN coordinated internation expert group, J. Pediatr. Gastroenteral. Nutr., 41, 584, 10.1097/01.mpg.0000187817.38836.42

Cook, 1989, Nutrient levles in infant formulas: Technical considerations, J. Nutr., 119, 1773, 10.1093/jn/119.suppl_12.1773

Paragaroufalis, 2014, A randomized double blind controlled safety trial evaluating d-lactic acid production in healthy infants fed a lactobacillus reuteri-containing formula, Nutr. Metab. Insights., 7, 19

Koletzko, 2013, European Childhood Obesity trial Study. Early influences of nutrition on postnatal growth, Nestle Nutr. Inst. Workshop Ser., 71, 11, 10.1159/000342533

Fanaro, 2010, Different pre-term formula for different pre-term infants, Early Hum. Dev., 86, 27, 10.1016/j.earlhumdev.2010.01.005

Michaelsen, 2014, Protein needs early in life and long-term health, Am. J. Clin. Nutr., 99, 718S, 10.3945/ajcn.113.072603

Hochwallner, 2014, Cow’s milk allergy: From allergens to new forms of diagnosis, therapy and prevention, Methods, 66, 22, 10.1016/j.ymeth.2013.08.005

Luyt, 2014, Standard of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI). BSACI guideline for the diagnosis and management of cow’s milk allergy, Clin. Exp. Allergy, 44, 642, 10.1111/cea.12302

Turck, 2013, Cow’s milk and goat’s milk, World Rev. Nutr. Diet., 108, 56, 10.1159/000351485

Katz, 2010, Early exposure to cow’s milk protein is protective against IgE-mediated cow’s milk protien allergy, J. Allergy Clin. Immunol., 126, 77, 10.1016/j.jaci.2010.04.020

Schiemare, 2015, Incidence and natural history of challenge-proven cow’s milk allergy in Europea children–EuroPrevall Birth, Allergy, 70, 963, 10.1111/all.12630

Perkin, M.R., Logan, K., Tseng, A., Raji, B., Ayis, S., Peacock, J., Brough, H., Marrs, T., Radulovic, S., and Craven, J. (2016). Randomized trial of introduction of allergenic foods in breast-fed infants. N. Engl. J. Med.

Fiocchi, 2010, World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) Guidelines, Pediatr. Allergy Immunol., 21, 1, 10.1111/j.1399-3038.2010.01068.x

Kate, 2015, Non-lgE-mediated gastrointestinal food allergy, J. Allergy Clin. Immunol., 135, 1114, 10.1016/j.jaci.2015.03.025

Upson, 2015, Early-life factors and endometriosis risk, Fertil. Steril., 104, 964, 10.1016/j.fertnstert.2015.06.040

Adgent, 2012, Early life soy exposure and age at menarahe, Peadiatr. Perinat. Epidemiol., 26, 163, 10.1111/j.1365-3016.2011.01244.x

Musilova, 2014, Beneficial effects of human milk oligosaccharides on gut microbiota, Benef. Microbes., 5, 273, 10.3920/BM2013.0080

Oozeer, 2012, Intestinal microbiology in early life: Specific prebiotics can have similar functionalities as human-milk oligosaccharides, Am. J. Clin. Nutr., 98, 561S, 10.3945/ajcn.112.038893

Bezirtzoglou, 2011, Microbiota profile in feces of breast- and formula-fed newborns by using fluorescence in situ hybridization (FISH), Anaerobe, 17, 478, 10.1016/j.anaerobe.2011.03.009

Chassard, 2014, Probiotics tailored to the infant: A window of opportunity, Curr. Opin. Biotechnol., 26, 141, 10.1016/j.copbio.2013.12.012

Albrecht, 2014, A comparative study of free oligosaccharides in the milk of domestic animals, Br. J. Nutr., 111, 1313, 10.1017/S0007114513003772

Asakuma, 2010, Short communication: Effect of grazing on the concentrations of total sialic acid and hexose in bovine milk, J. Dairy Sci., 93, 4850, 10.3168/jds.2010-3357

Coulet, 2014, Pre-clinical safety evaluation of the synthetic human milk, nature-identical, oligosaccharide 2′-O-Fucosyllactose (2′FL), Regul. Toxicol Pharmacol., 68, 59, 10.1016/j.yrtph.2013.11.005

Sung, V., Hiscock, H., Tang, M.L., Mensah, F.K., Nation, M.L., Salzke, C., Heine, R.G., Stock, A., Barr, R.G., and Wake, M. (2014). Treating infant colic with the probiotic Lactobacillus reuteri: Double blind, placebo controlled randomised trial. BMJ, 348.

Partty, 2013, Effects of early prebiotic and probiotic supplementation on development of gut microbiota and fussing and crying in preterm infants: A randomized, double-blind, placebo-controlled trial, J. Pediatr., 163, 1272, 10.1016/j.jpeds.2013.05.035

Zou, 2013, Lipid composition analysis of milk fats from different mammalian species: Potential for use as human milk fat substitutes, J. Agric. Food Chem., 61, 7070, 10.1021/jf401452y

Luoto, 2014, Prebiotic and probiotic supplementation prevents rhinovirus infections in preterm infants: A randomized, placebo-controlled trial, J. Allergy Clin. Immunol., 133, 405, 10.1016/j.jaci.2013.08.020

Lonnerdal, 2011, Biological effects of novel bovine milk fractions, Nestle Nutr. Workshop Ser. Pediatr. Program., 67, 41, 10.1159/000325574

Timby, 2014, Neurodevelopment, nutrition, and growth until 12 mo of age in infants fed a low-energy, low-protein formula supplemented with bovine milk fat globule membranes: A randomized controlled trial, Am. J. Clin. Nutr., 99, 860, 10.3945/ajcn.113.064295