Retracted: Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR‐133/PRDM16 pathway

International Journal of Cancer - Tập 144 Số 10 - Trang 2501-2515 - 2019
Haiyang Zhang1, Lei Zhu1, Ming Bai1, Ying Liu1, Zhan Yang1, Ting Deng1, Haiou Yang1, Wu Sun1, Xinyi Wang1, Kegan Zhu1, Qian Fan1, Jialu Li2,3,4, Guoguang Ying1, Yi Ba1
1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China
2Division of Gastroenterology and Hepatology Shanghai Institute of Digestive Disease; Key Laboratory of Gastroenterology and Hepatology, Ministry of Health; Shanghai Jiao‐Tong University School of Medicine Renji Hospital Shanghai China
3Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease
4Key Laboratory of Gastroenterology and Hepatology, Ministry of Health

Tóm tắt

Cancer‐related cachexia is a metabolic syndrome characterized by a wasting disorder of adipose and skeletal muscle and is accompanied by body weight loss and systemic inflammation. The treatment options for cancer cachexia are limited, and the molecular mechanism remains poorly understood. Circular RNAs (circRNAs) are a novel family of endogenous noncoding RNAs that have been proposed to regulate gene expression in mammals. Exosomes are small vesicles derived from cells, and recent studies have shown that circRNAs are stable in exosomes. However, little is known about the biological role of circRNAs in exosomes. In our study, we showed that circRNAs in plasma exosomes have specific expression features in gastric cancer (GC), and ciRS‐133 is linked with the browning of white adipose tissue (WAT) in GC patients. Exosomes derived from GC cells deliver ciRS‐133 into preadipocytes, promoting the differentiation of preadipocytes into brown‐like cells by activating PRDM16 and suppressing miR‐133. Moreover, knockdown of ciRS‐133 reduced cancer cachexia in tumor‐implanted mice, decreasing oxygen consumption and heat production. Thus, exosome‐delivered circRNAs are involved in WAT browning and play a key role in cancer‐associated cachexia.

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Thông tin xuất bản

International Journal of Cancer

Tập 144 Số 10

2501-2515

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