Retinal damage secondary to chronic light exposure
Tóm tắt
The effect upon the retina of exposure to large fields of bright visible light has been evaluated. The thresholds for permanent retinal damage for four hour exposures in rhesus monkeys have been established for white light, and laser lines of 514.5 nm, 488 nm, 457.9 nm, and 590 nm. The damage has been evaluated by ophthalmosoopy, electroretinography and light and electron microscopy. The shortest wavelength light (457.9 nm) is more effective in causing damage, particularly histological damage, which is spread throughout the fundus and throughout the retinal layers. Functional damage shown by the electroretinogram follows a different action spectrum without the increased effect in the blue. There appears to be more than one mechanism for retinal damage in chronic light exposure, and at least one mechanism is not dependent solely upon the visual pigment and the pigment epithelium. Thresholds of permanent damage appear to be within one or two log units of light levels encountered in the normal visual environment. Newer data suggest that this damage is additive. Daily one hour exposures for four days produce damage equivalent to a single four hour exposure at the same retinal irradiance.
Tài liệu tham khảo
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