Hiện Tượng Mỏng Xuống Của Thể Võ Nguyên Ở Người Lớn Bị Rối Loạn Phổ Tự Kỷ

Evelyn B. N. Friedel1,2,3, Ludger Tebartz van Elst1, Mirjam Schäfer4, Simon Maier4, Kimon Runge1, Sebastian Küchlin2, Michael Reich2, Wolf A. Lagrèze2, Jürgen Kornmeier1,5, Dieter Ebert4, Dominique Endres1, Katharina Domschke1,6, Kathrin Nickel1
1Department of Psychiatry and Psychotherapy, Medical Center, University of Freiburg, Faculty of Medicine University of Freiburg, Freiburg, Germany
2Eye Center, Medical Center – University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
3Faculty of Biology, University of Freiburg, Freiburg, Germany
4Department of Psychiatry and Psychotherapy, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany
5Institute for Frontier Areas of Psychology and Mental Health, Freiburg, Germany
6Center for Basics in NeuroModulation, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Tóm tắt

Do võng mạc có nguồn gốc phôi thai chung với hệ thần kinh trung ương, chụp cắt lớp quang học (OCT), một kỹ thuật hình ảnh thường được sử dụng trong nhãn khoa để phân tích độ dày và thể tích của điểm vàng và lớp nhân ngoài (ONL), đã trở nên ngày càng quan trọng trong nghiên cứu tâm thần. Chúng tôi đã khảo sát 34 người lớn tự kỷ và 31 người lớn không tự kỷ (NT) bằng cách sử dụng OCT. Những người lớn tự kỷ có độ dày và thể tích tổng thể của điểm vàng và lớp nhân ngoài (ONL) giảm so với nhóm NT. Cả độ dày của điểm vàng và ONL đều cho thấy mối liên hệ ngược rõ rệt với mức độ nghiêm trọng của các triệu chứng tự kỷ được đo bằng Thang Đo Lường Đáp Ứng Xã Hội 2 (SRS-2). Các nghiên cứu theo chiều dài trên các nhóm tuổi khác nhau là cần thiết để làm rõ liệu những thay đổi ở võng mạc có thể đại diện cho dấu hiệu đặc trưng nào đó.

Từ khóa

#Rối loạn phổ tự kỷ #chụp cắt lớp quang học #võng mạc #độ dày #triệu chứng tự kỷ #Thang Đo Lường Đáp Ứng Xã Hội 2

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