Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo

American Association for the Advancement of Science (AAAS) - Tập 308 Số 5726 - Trang 1314-1318 - 2005
Axel Nimmerjahn1,2, Frank Kirchhoff1,2, Fritjof Helmchen1,2
1Abteilung Neurogenetik, Max Planck Institut für Experimentelle Medizin, Hermann-Rein-Strasse 3, 37075 Göttingen, Germany.
2Abteilung Zellphysiologie, Max Planck Institut für Medizinische Forschung, Jahnstrasse 29, 69120 Heidelberg, Germany.

Tóm tắt

Microglial cells represent the immune system of the mammalian brain and therefore are critically involved in various injuries and diseases. Little is known about their role in the healthy brain and their immediate reaction to brain damage. By using in vivo two-photon imaging in neocortex, we found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions. Furthermore, blood-brain barrier disruption provoked immediate and focal activation of microglia, switching their behavior from patroling to shielding of the injured site. Microglia thus are busy and vigilant housekeepers in the adult brain.

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Tài liệu tham khảo

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Materials and methods are available as supporting material on Science Online.

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We thank S. Erdogan for help with the analysis J. N. D. Kerr and G. W. Kreutzberg for comments on the manuscript S. Jung and D. R. Littman for providing the green fluorescent microglia mouse line and B. Sakmann for generous support. This work was supported by a predoctoral fellowship of the Boehringer Ingelheim Fonds to A.N.

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American Association for the Advancement of Science (AAAS)

Tập 308 Số 5726

1314-1318

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