Resolution of chronic hypoxemia in pediatric sickle cell patients after treatment with hydroxyurea

Pediatric Blood and Cancer - Tập 50 Số 6 - Trang 1258-1260 - 2008
Sharon Singh1, Anastassios C. Koumbourlis2, Banu Aygün3,4
1Pediatric Hematology/Oncology and Stem Cell Transplantation, Albert Einstein College of Medicine, Schneider Children's Hospital, New Hyde Park, New York, USA.
2Pediatric Pulmonology, Albert Einstein College of Medicine, Schneider Children's Hospital, New Hyde Park, New York
3Department of Hematology, St. Jude Children's Research Hospital, M/S 800, 332 N. Lauderdale, Memphis, TN 38105.
4Pediatric Hematology/Oncology and Stem Cell Transplantation, Albert Einstein College of Medicine, Schneider Children's Hospital, New Hyde Park, New York

Tóm tắt

AbstractChronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly after they were treated with hydroxyurea despite having additional risk factors for hypoxemia. A prospective trial is warranted to assess whether there is a therapeutic effect from the use of hydroxyurea in pediatric SCA patients with chronic hypoxemia. Pediatr Blood Cancer 2008;50:1258–1260. © 2008 Wiley‐Liss, Inc.

Từ khóa


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Thông tin
Thông tin xuất bản

Pediatric Blood and Cancer

Tập 50 Số 6

1258-1260

Thông tin tác giả