Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies

International Journal of Environmental Research and Public Health - Tập 17 Số 4 - Trang 1457
Jia Li1,2, Chunhong Wang1, Jun Yu1, Yongsheng Fan1, Duanya Liu1, Wenshan Zhou2, Tingming Shi2
1Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China.
2Hubei Provincial Center for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan 430079, Hubei, China.

Tóm tắt

Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Science and Chinese National Knowledge Infrastructure for papers published up to 13 November 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed and random effects models. Subgroup and dose‒response analyses were also conducted. This study was registered with PROSPERO (No. CRD42019127761). A total of 28 studies, which included 13,748 lung cancer cases and 23,112 controls, were used for this meta-analysis. The pooled OR indicated that the highest residential radon exposure was significantly associated with an increased risk of lung cancer (OR = 1.48, 95% CI = 1.26–1.73). All histological types of lung cancer were associated with residential radon. Strongest association with small-cell lung carcinoma (OR = 2.03, 95% CI = 1.52–2.71) was found, followed by adenocarcinoma (OR = 1.58, 95% CI = 1.31–1.91), other histological types (OR = 1.54, 95% CI = 1.11–2.15) and squamous cell carcinoma (OR = 1.43, 95% CI = 1.18–1.74). With increasing residential radon levels per 100 Bq/m3, the risk of lung cancer, small-cell lung carcinoma and adenocarcinoma increased by 11%, 19% and 13%, respectively. This meta-analysis provides new evidence for a potential relationship between residential radon and all histological types of lung cancer.

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International Journal of Environmental Research and Public Health

Tập 17 Số 4

1457

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