Repeated exposure of rat pups to isolation attenuates isolation‐induced ultrasonic vocalization rates: Reversal with naltrexone

Developmental Psychobiology - Tập 27 Số 1 - Trang 53-64 - 1994
Gregory A. Goodwin1, Vı́ctor A. Molina1, Linda P. Spear1
1Center for Developmental Psychobiology, Binghamton University, Binghamton, New York

Tóm tắt

AbstractYoung rat pups are dependent on the dam for their survival, thus isolation of the neonatal rat pup from the dam presents the young organism with a variety of stressors. The question examined in this study concerns the ability of the young rat pup to modify its response to isolation following repeated exposure to that isolation as well as the role played by endogenous opiates in this process. Following repeated isolations, pups were seen to decrease vocalization rates. Altering the context in an attempt to dishabituate animals failed to reverse the decreased vocalization rate. However, opiate receptor blockade attenuated this decrease when administered subsequent to the first isolation period but not prior to the last isolation period. These results suggest that the development of this attenuated response to isolation stress is opiate‐mediated but that once established, its expression is not dependent on endogenous opiate release.© 1994 John Wiley & Sons, Inc.

Từ khóa


Tài liệu tham khảo

10.1016/0091-3057(88)90266-3

10.1037/0735-7044.104.5.808

10.1016/S0166-4328(05)80296-7

10.1016/0006-8993(84)91156-9

10.1016/0014-2999(87)90140-3

10.1016/0361-9230(91)90159-H

10.1016/0014-2999(90)90025-2

10.1016/0165-3806(91)90185-L

10.1037/0735-7044.104.1.160

10.1037/0735-7044.104.3.457

10.1016/0031-9384(91)90363-S

Evoniuk G. E., 1979, The effect of tactile stimulation on serum growth hormone and tissue ornithine decarboxylase activity during maternal deprivation in rat pups, Communications in Psychopharmacology, 3, 363

10.1002/dev.420260202

10.1002/dev.420190410

10.1002/dev.420240206

10.1016/0006-8993(85)90684-5

10.1126/science.684424

10.1002/dev.420230503

10.1016/0003-3472(68)90123-1

10.1016/0091-3057(89)90566-2

10.1016/0024-3205(86)90359-0

10.1016/S0091-6773(74)91026-8

10.1016/S0163-1047(85)91121-5

10.1016/S0149-7634(87)80009-X

10.1016/0018-506X(79)90029-1

10.1210/endo-114-2-618

10.1007/BF00427414

10.1016/0278-5846(91)90003-J

10.1037/0735-7044.105.2.253

Thông tin
Thông tin xuất bản

Developmental Psychobiology

Tập 27 Số 1

53-64

Thông tin tác giả