Reliability and Validity of Composite Scores from the NIH Toolbox Cognition Battery in Adults

Journal of the International Neuropsychological Society - Tập 20 Số 6 - Trang 588-598 - 2014
Robert K. Heaton1, Roger Bakeman1, David S. Tulsky2, Dan Mungas3, Sandra Weıntraub4, Sureyya Dikmen5, Jennifer L. Beaumont6, Kaitlin B. Casaletto7, Kevin P. Conway8, Jerry Slotkin6, Richard Gershon6
11Department of Psychiatry,University of California,San Diego,California.
22Departments of Rehabilitation Medicine,Orthopedic Surgery, and General Medicine,New York University Langone Medical Center,New York; and Spinal Cord Injury,Kessler Foundation,West Orange,New Jersey.
33Department of Neurology,University of California,Davis,California.
44Cognitive Neurology and Alzheimer's Disease Center and Department of Psychiatry and Behavioral Sciences,Northwestern Feinberg School of Medicine,Chicago,Illinois.
55Department of Rehabilitation Medicine,University of Washington,Seattle,Washington.
66Department of Medical Social Sciences,Northwestern University,Chicago,Illinois.
77San Diego State University/University of California,San Diego Joint Doctoral Program in Clinical Psychology,San Diego,California.
88National Institute on Drug Abuse,Rockville,Maryland.

Tóm tắt

AbstractThis study describes psychometric properties of the NIH Toolbox Cognition Battery (NIHTB-CB) Composite Scores in an adult sample. The NIHTB-CB was designed for use in epidemiologic studies and clinical trials for ages 3 to 85. A total of 268 self-described healthy adults were recruited at four university-based sites, using stratified sampling guidelines to target demographic variability for age (20–85 years), gender, education, and ethnicity. The NIHTB-CB contains seven computer-based instruments assessing five cognitive sub-domains: Language, Executive Function, Episodic Memory, Processing Speed, and Working Memory. Participants completed the NIHTB-CB, corresponding gold standard validation measures selected to tap the same cognitive abilities, and sociodemographic questionnaires. Three Composite Scores were derived for both the NIHTB-CB and gold standard batteries: “Crystallized Cognition Composite,” “Fluid Cognition Composite,” and “Total Cognition Composite” scores. NIHTB Composite Scores showed acceptable internal consistency (Cronbach’s alphas=0.84 Crystallized, 0.83 Fluid, 0.77 Total), excellent test–retest reliability (r: 0.86–0.92), strong convergent (r: 0.78–0.90) and discriminant (r: 0.19–0.39) validities versus gold standard composites, and expected age effects (r=0.18 crystallized, r=−0.68 fluid, r=−0.26 total). Significant relationships with self-reported prior school difficulties and current health status, employment, and presence of a disability provided evidence of external validity. The NIH Toolbox Cognition Battery Composite Scores have excellent reliability and validity, suggesting they can be used effectively in epidemiologic and clinical studies. (JINS, 2014, 20, 1–11)

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Thông tin xuất bản

Journal of the International Neuropsychological Society

Tập 20 Số 6

588-598

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