Khả năng kháng tương đối của virus HIV-1 nguồn đối với sự kiểm soát của interferon-alpha
Tóm tắt
Sau khi truyền HIV loại 1 (HIV-1) qua màng nhầy, interferon loại 1 (IFN) được sản xuất nhanh chóng tại các vị trí virus nhân lên ban đầu trong màng nhầy và các hạch bạch huyết thoát nước. Tuy nhiên, vai trò của hoạt động kháng virus kích thích bởi IFN trong việc hạn chế sự nhân lên của HIV-1 trong các giai đoạn đầu của nhiễm trùng vẫn chưa rõ ràng. Chúng tôi giả thuyết rằng nếu IFN loại 1 tác động chọn lọc lên sự nhân lên của HIV-1 trong những giai đoạn đầu của nhiễm trùng, các virus nguồn thành công trong việc thiết lập nhiễm trùng hệ thống sẽ kháng IFN hơn so với các virus đang nhân lên trong tình trạng nhiễm trùng mãn tính, khi mà IFN loại 1 được sản xuất ở mức thấp hơn nhiều. Để kiểm tra giả thuyết này, độ kháng tương đối của các chủng virus derived từ những cá nhân nhiễm HIV-1 trong giai đoạn cấp tính và mãn tính đối với sự kiểm soát của IFN loại 1 đã được phân tích.
Sự nhân lên của các chủng virus huyết tương được tạo ra từ những đối tượng bị nhiễm HIV-1 cấp tính và các chủng HIV-1 nguồn được nhân bản phân tử có thể bị giảm nhưng không bị ức chế hoàn toàn bởi IFN loại 1
Từ khóa
#HIV-1 #interferon-alpha #khả năng kháng #nhiễm trùng cấp tính #sự kiểm soát virusTài liệu tham khảo
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