Relationship between serum interleukin-6 levels and severity of coronary artery disease undergoing percutaneous coronary intervention
Tóm tắt
Cytokines play a potential role in atherosclerosis pathogenesis and progression. We investigated the association of interleukin-6 (IL-6) with the angiographic severity of coronary artery disease (CAD).
Three hundred ten angiografically diagnosed CAD patients and 210 controls were enrolled in this study. CAD patients were stratified according to IL-6 cut-off value into high levels IL-6 group (≥ 9.5 pg/mL) and low levels IL-6 group (< 9.5 pg/mL). The severity of CAD was assessed according to Gensini score (GS), artery stenosis degree and the number of vessels involved. The mean age was 60.3 ± 11.0 years.
The level of IL-6 in patients was increased compared to controls and ranged from 1.5 to 3640.0 pg/mL. High levels of IL-6 were significantly associated with high levels of GS (> 40) but not with stenosis degree and vessel score. GS levels were significantly more elevated in patients with high levels of IL-6 group than in low IL6 levels patients (60.6 ± 39.5
IL-6 levels were associated with the severity of CAD assessed by the GS. Based on the highest levels of IL-6 measured in patients with STEMI, our study strongly suggests that IL-6 could be a powerful marker in evaluating the myocardial necrosis.
ClinicalTrials.gov Number: NCT03075566 (09/03/2017).
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Bouzidi N, Betbout F, Maatouk F. Relationship of activin A levels with clinical presentation, extent, and severity of coronary artery disease. Anatol J Cardiol. 2017;18:402–9. https://doi.org/10.14744/AnatolJCardiol.2017.7935.
Favero G, Paganelli C, Buffoli B. Endothelium and its alterations in cardiovascular diseases: life style intervention. Biomed Res Int. 2014;2014:801896. https://doi.org/10.1155/2014/801896.
Ozkaramanli Gur D, Guzel S, Akyuz A. The role of novel cytokines in inflammation: defining peripheral artery disease among patients with coronary artery disease. Vasc Med. 2018;23:428–36. https://doi.org/10.1177/1358863X18763096.
Fanola CL, Morrow DA, Cannon CP. Interleukin-6 and the risk of adverse outcomes in patients after an acute coronary syndrome: observations from the SOLID-TIMI 52 (Stabilization of Plaque Using Darapladib—Thrombolysis in Myocardial Infarction 52) trial. J Am Heart Assoc. 2017;6:e005637. https://doi.org/10.1161/JAHA.117.005637.
Yanjia C, Hui H, Xiaoxiang Y. Tetranectin as a potential biomarker for stable coronary artery disease. Sci Rep. 2015;5:17632. https://doi.org/10.1038/srep17632.
Vibeke NR, Ingebjørg S, Harald A. IL-6 signalling in patients with acute ST-elevation myocardial infarction. Results Immunol. 2013;14:813. https://doi.org/10.1016/j.rinim.2013.11.002.
Simon TG, Trejo MEP, McClelland R. Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: results from the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2018;259:198–204. https://doi.org/10.1016/j.ijcard.2018.01.046.
Zhang Y, Shao T, Yao L. Effects of tirofban on stent thrombosis, Hs-CRP, IL-6 and sICAM-1 after PCI of acute myocardial infarction. Exp Ther Med. 2018;16:3383–8. https://doi.org/10.3892/etm.2018.6589.
Bouzidi N, Ben Messaoud M, Maatouk F. Relationship between high sensitivity C-reactive protein and angiographic severity of coronary artery disease. J Geriatr Cardiol. 2020;17:256–63. https://doi.org/10.11909/j.issn.1671-5411.2020.05.003.
Roffi M, Patrono C, Collet JP. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). Eur Heart J. 2016;37:267–315. https://doi.org/10.1093/eurheartj/ehv320.
Dimitris T, Gerasimos S, Konstantinos M. Serum osteoprotegerin and osteopontin levels are associated with arterial stiffness and the presence and severity of coronary artery disease. Int J Cardiol. 2013;167(5):1924–8. https://doi.org/10.1016/j.ijcard.2012.05.001.
Perkins NJ, Schisterman EF. The youden index and the optimal cut-point corrected for measurement error. Biom J. 2005;47:428–41. https://doi.org/10.1002/bimj.200410133.
Tanindi A, Sahinarslan A, Elbeg S. Relation between MMP-1, MMP-9, TIMP-1, IL-6 and risk factors, clinical presentation, extent and severity of atherosclerotic coronary artery disease. Open Cardiovasc Med J. 2011;5:110–6. https://doi.org/10.2174/1874192401105010110.
Ling Y, Weng H, Tang S. The relationship between IL-6 levels and the angiographic severity of coronary artery disease following percutaneous coronary intervention in acute coronary syndrome patients. BMC Cardiovasc Disord. 2021;21:578. https://doi.org/10.1186/s12872-021-02406-7.
Liu CL, Sben DL, Zbu K. Levels of interleukin-33 and interleukin-6 in patients with acute coronary syndrome or stable angina. Clin Invest Med J. 2013;36:E234-241. https://doi.org/10.25011/cim.v36i4.19957.
Simon TG, Trejo MEP, McClelland R. Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis. Int J Cardiol. 2018;259:198–204. https://doi.org/10.1016/j.ijcard.2018.01.046.
Shim AL, Aksyonov AA, Mitrokhin VM. Serum interleukin-6: association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease. Cell Immunol. 2016;310:178–83. https://doi.org/10.1016/j.cellimm.2016.09.007.
Nambi V, Hoogeveen RC, Chambless L. Lipoprotein-Associated Phospholipase A2 and High-Sensitivity C Reactive Protein Improve the Stratification of Ischemic Stroke Risk in the Atherosclerosis Risk in Communities (ARIC) Study. Stroke. 2009;40:376–81. https://doi.org/10.1161/STROKEAHA.107.513259.
Bonda T, Kaminski KA, Kozuch M. Musial Circadian variations of interleukin 6 in coronary circulations of patients with myocardial infarction. Cytokine. 2010;50:204–9. https://doi.org/10.1016/j.cyto.2010.01.007.
Karabağ Y, Çağdaş M, Rencuzogullari I, et al. Relationship between C-reactive protein/albumin ratio and coronary artery disease severity in patients with stable angina pectoris. J Clin Lab Anal. 2018;32:e22457. https://doi.org/10.1002/jcla.22457.
Kaminski KA, Kozuch M, Bonda T. Coronary sinus concentrations of interleukin 6 and its soluble receptors are effected by reperfusion and may portend complications in patients with myocardial infarction. Atherosclerosis. 2009;206:581–7. https://doi.org/10.1016/j.atherosclerosis.2009.03.033.
Woods A, Brull DJ, Humphries SE. Genetics of inflammation and risk of coronary artery disease: the central role of interleukin-6. Eur Heart J. 2000;21:1574–83. https://doi.org/10.1053/euhj.1999.2207.
Tang JN, Shen DL, Liu CL. Plasma levels of C1q/TNF-related protein 1 and interleukin 6 in patients with acute coronary syndrome or stable angina pectoris. Am J Med Sci. 2015;349:130–6. https://doi.org/10.1097/MAJ.0000000000000378.
Wang XH, Liu SQ, Wang YL. Correlation of serum high-sensitivity C-reactive protein and interleukin-6 in patients with acute coronary syndrome. Genet Mol Res. 2014;13:4260–6. https://doi.org/10.4238/2014.
Zhao L, Wang X, Yang Y. Association between interleukin-6 and the risk of cardiac events measured by coronary computed tomography angiography. Int J Cardiovasc Imaging. 2017;33:1237–44. https://doi.org/10.1007/s10554-017-1098-y.
Liao F, Andalibi A, Qiao JH. Genetic evidence for a common pathway mediating oxidative stress, inflammatory gene induction, and aortic Fatty streak formation in mice. J Clin Invest. 1994;94:877–84. https://doi.org/10.1172/JCI117409.
Frostegard J, Wu R, Giscombe R. Induction of T-cell activation by oxidized low density lipoprotein. Arterioscle Thromb. 1992;12:461–7. https://doi.org/10.1161/01.atv.12.4.461.
Diamantis E, Kyriakos G, Quiles-Sanchez LV. The anti-inflammatory effects of statins on coronary artery disease: an updated review of the literature. Curr Cardiol Rev. 2017;13:209–2016. https://doi.org/10.2174/1573403X13666170426104611.
Mizuno Y, Jacob RF, Mason RP. Inflammation and the development of atherosclerosis. J Atheroscler Thromb. 2011;18(5):351–8. https://doi.org/10.5551/jat.7591.
Triyano T, Pariding J, Sukorini U. Correlation of IL-6 and monocyte count to Troponin I in acute coronary syndrome. Berkala Ilmu kedokteran. 2008;40:189–92.
Biasucci LM, Vitelli A, Liuzzo G, Altamura S, Caligiuri G, Monaco C, Rebuzzi AG, Ciliberto G, Maseri A. Elevated levels of interleukin-6 in unstable angina. Cirotlarion. 1996;94:874–7.