Relationship between blood flow and radiostrontium uptake in the healing bone fracture
Tóm tắt
The healing of a diaphyseal tibia fracture was followed in the rat. Callus formation, blood flow and Sr-85 uptake were assessed by a ratio comparison of the fractured to the contralateral side. No correlation was found between blood flow and Sr-85 deposition in the callus and the adjacent bone of the same extremity. It is concluded that the deposition of a radiopharmaceutical in bone is primarily related to the presence of calcifiable organic bone matrix and only secondarily to the bone formation rate and to variations in the local blood flow.
Tài liệu tham khảo
Albright, F., Reifenstein, E.C.: The parathyroid glands and metabolic bone disease. Baltimore: Williams, Wilkins 1948
van Dyke, D., Anger, H.O., Yano, Y., Bozzini, C.: Bone blood flow as shown with F18 and the positron camera. Am. J. Physiol. 209, 65–70, (1965)
Fleisch, H., Russel, R.G.G.: Pyrophosphate and polyphosphate. International Encyclopedia of Pharmacology and Therapeutics, Sect. 51, Vol. 1, pp. 61–99. Oxford: Pergamon 1970
Fourman, P.: Calcium metabolism and the bone. Oxford: Blackwell Scientific Publications 1960
Fueger, G.F.: Nuklearmedizinische Untersuchungen an Frakturen. In: Ergebnisse der medizinischen Radiologie, R. Glauner (ed.), Bd. VI. Stuttgart: G. Thieme 1973
Genant, H.K., Bautowich, G.J., Singh, M., Lathrop, K.A., Harper, P.V.: Bone seeking radionuclides: An in vivo study of factors affecting skeletal uptake. Radiology 113, 373–382 (1974)
Glimcher, M.J.: Composition, structure, and organisation of bone and other mineralized tissues and the mechanism of calcification. In: Handbook of physiology. Section 7, Endocrinology, Vol. VII, pp. 25–116, Parathyroid gland. Washington: American Physiological Society 1976
Jowsey, J.: Metabolic diseases of bone. Vol. 1 in the series: Saunders monographs in clinical orthropaedics. p. 53. Philadelphia, London, Toronto: Saunders 1977
Schümichen, C., Rempfle, H., Wagner, M., Hoffmann, G.: The short-term fixation of radiopharmaceuticals in bone. Eur. J. Nucl. Med. 4, 423–428 (1979)
Shtacher, G., Firschein, H.E.: Collagen and mineral kinetics in bone after fracture. Am. J. Physiol. 213, 863–866 (1967)
Siegel, B.A., Donovan, R.L., Alderson, P.O., Mack, G.R.: Skeletal uptake of 99mTc-diphosphonate in relation to local bone blood flow. Radiology 120, 121–123 (1976)
Solheim, K.: Fracture healing in rats studied with radioactive phosphorus. Acta Chir. Scand. 129, 131–138 (1965)
Vaughan, J.M.: The physiology of bone. Oxford: Clarendon Press 1975
Weidmann, S.M.: Calcification of skeletal tissues. Int. Rev. Connect. Tiss. Res. 1, 339–377 (1963)
Wootton, R.: The single-passage extraction of 18F in rabbit bone. Clin. Sci. Molec. Med. 47, 73–77 (1974)