Relationship between Periodontitis and Rheumatoid Arthritis: Review of the Literature
Tóm tắt
Periodontitis (PD) and rheumatoid arthritis (RA) are immunoinflammatory diseases where leukocyte infiltration and inflammatory mediators induce alveolar bone loss, synovitis, and joint destruction, respectively. Thus, we reviewed the relationship between both diseases considering epidemiological aspects, mechanical periodontal treatment, inflammatory mediators, oral microbiota, and antibodies, using the keywords “periodontitis” and “rheumatoid arthritis” in PubMed database between January 2012 and March 2015, resulting in 162 articles. After critical reading based on titles and abstracts and following the inclusion and exclusion criteria, 26 articles were included. In the articles, women over 40 years old, smokers and nonsmokers, mainly constituted the analyzed groups. Eight studies broached the epidemiological relationship with PD and RA. Four trials demonstrated that the periodontal treatment influenced the severity of RA and periodontal clinical parameters. Nine studies were related with bacteria influence in the pathogenesis of RA and the presence of citrullinated proteins, autoantibodies, or rheumatoid factor in patients with PD and RA. Five studies investigated the presence of mediators of inflammation in PD and RA. In summary, the majority of the articles have confirmed that there is a correlation between PD and RA, since both disorders have characteristics in common and result from an imbalance in the immunoinflammatory response.
Từ khóa
Tài liệu tham khảo
Lima V., 2008, Principais mediadores inflamatórios envolvidos na fisiopatologia da periodontite–papel dos moduladores farmacológicos, R Periodontia, 18, 7
Bhuvaneswarri1 J., 2014, Detection of RANKL positive cells in gingival tissue in healthy and chronic periodontal disease patients—a comparative study, Journal of Clinical and Diagnostic Research, 8, 31
Moen K., 2006, Synovial inflammation in active rheumatoid arthritis and psoriatic arthritis facilitates trapping of a variety of oral bacterial DNAs, Clinical and Experimental Rheumatology, 24, 656
Doran M. F., 2004, The effect of oral contraceptives and estrogen-replacement therapy on the risk of rheumatoid arthritis: a population based study, The Journal of Rheumatology, 31, 207
Beeraka S. S., 2013, Clinical and radiological assessment of effects of long-term corticosteroids therapy on oral health, Dental Research Journal, 10, 666