Regulation of neuronal cdc20 (p55cdc) expression by the plasticity‐related transcription factor zif268

Synapse - Tập 61 Số 6 - Trang 463-468 - 2007
Ann-Marie Conway1, Allan B. James2, Jie Zang2, Brian Morris3
1Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, UK
2Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, University of Glasgow, Glasgow, Scotland, United Kingdom.
3Division of Neuroscience and Biomedical Systems, Institute of Biomedical and Life Sciences, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK

Tóm tắt

AbstractMost forms of neuronal plasticity are associated with induction of the transcription factor zif268 (egr1). Down‐regulation of cdc20 (p55cdc)—a regulatory protein for the anaphase‐promoting complex, which controls access of specific substrates to the proteasome—was observed after transfection of a neuronal cell line with zif268. Treatment of cultured hippocampal neurones with NMDA, which elevates endogenous zif268 levels, also decreased cdc20 levels. Conversely, the levels of cdc20 were found to be increased in the cerebral cortex of mice with targeted deletion of the zif268 gene, when compared with wild‐type controls. Our findings indicate that expression of the cdc20 gene is down‐regulated by zif268 in neuronal cells, and provide new evidence that altered expression of proteasome‐regulatory genes following zif268 induction may be a key component of long‐lasting CNS plasticity. Synapse 61:463‐468, 2007. © 2007 Wiley‐Liss, Inc.

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Synapse

Tập 61 Số 6

463-468

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