Regular consumption of soft drinks is associated with type 2 diabetes incidence in Mexican adults: findings from a prospective cohort study

Leticia Torres‐Ibarra1, Berenice Rivera‐Paredez2, Rubí Hernández‐López2, Francisco Canto‐Osorio1, Luz María Sánchez-Romero1, Nancy López-Olmedo1, Romina González-Morales1, Paula Ramírez3, Jorge Salmerón2, Tonatiuh Barrientos‐Gutiérrez1
1Center for Population Health Research, National Institute of Public Health, Cuernavaca,Morelos,Mexico
2Research Center on Policies, Population, and Health. Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico
3Epidemiological Research and Health Services Unit, Mexican Institute of Social Security, Cuernavaca, Morelos, Mexico

Tóm tắt

Abstract Background

Although high consumption of soft drinks has been associated with excess of type 2 diabetes risk, the strength of this association in the Mexican population, where a type 2 diabetes genetic susceptibility has been well established, has been scarcely studied. This study aimed to estimate the risk of type 2 diabetes due to soft drinks consumption in a cohort of Mexicans.

Methods

We used data on 1445 participants from the Health Workers Cohort Study, a prospective cohort conducted in Cuernavaca, Mexico. Soft drinks consumption was assessed with a semi-quantitative 116-item food frequency questionnaire. Incident type 2 diabetes was defined as self-report of physician-diagnosed type 2 diabetes, fasting glucose > 126 mg/dl, or hypoglycemic medication at any examination. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazard models.

Results

With a total of 9526.2 person-years of follow-up, 109 incident cases of type 2 diabetes were observed. Type 2 diabetes incidence rate was 7.6, 11.0, and 17.1 per 1000 person-years across levels of soft drinks consumption of < 1, 1–4, and ≥ 5 servings/week, respectively (p < 0.001 for trend). The intake of ≥5 soft drinks/week was significantly associated with an increased risk of type 2 diabetes (HR 1.9 95% CI:1.0–3.5) compared with consumption of < 1/week (p-trend = 0.040). The HR was attenuated by further adjustment for body mass index (HR 1.5 95%CI:0.8–2.8) and abdominal obesity (HR 1.6 95%CI:0.8–3.0).

Conclusions

The consumption of soft drinks was associated with a higher risk of type 2 diabetes in a cohort of Mexican adults. Our results further support recommendations to limit soft drinks intake to address the growing diabetes epidemic in Mexico.

Từ khóa


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