Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice

eLife - Tập 8
Valentina Bonnefil1, Karen Dietz2,3, Mario Amatruda1, Maureen Wentling1, Antonio Aubry4, Jeffrey L. Dupree5, Gary Temple1, Hye-Jin Park1, Nesha S. Burghardt4, Patrizia Casaccia1,2,3, Jia Liu1
1Advanced Science Research Center at the Graduate Center, Neuroscience Initiative, City University, New York, United States
2Department of Neuroscience, Icahn School of Medicine, New York, United States
3Friedman Brain Institute, Icahn School of Medicine, New York, United States
4Department of Psychology, Hunter College, City University, New York, United States
5Department of Anatomy and Neurobiology, Virginia Commonwealth University, Richmond, United States

Tóm tắt

Exposure to stress increases the risk of developing mood disorders. While a subset of individuals displays vulnerability to stress, others remain resilient, but the molecular basis for these behavioral differences is not well understood. Using a model of chronic social defeat stress, we identified region-specific differences in myelination between mice that displayed social avoidance behavior (‘susceptible’) and those who escaped the deleterious effect to stress (‘resilient’). Myelin protein content in the nucleus accumbens was reduced in all mice exposed to stress, whereas decreased myelin thickness and internodal length were detected only in the medial prefrontal cortex (mPFC) of susceptible mice, with fewer mature oligodendrocytes and decreased heterochromatic histone marks. Focal demyelination in the mPFC was sufficient to decrease social preference, which was restored following new myelin formation. Together these data highlight the functional role of mPFC myelination as critical determinant of the avoidance response to traumatic social experiences.Editorial note: This article has been through an editorial process in which the authors decide how to respond to the issues raised during peer review. The Reviewing Editor's assessment is that all the issues have been addressed (<xref ref-type="decision-letter" rid="SA1">see decision letter</xref>).

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