Regenerative endodontics: a comprehensive review

International Endodontic Journal - Tập 51 Số 12 - Trang 1367-1388 - 2018
S. G. Kim1, Matthew Malek2, Ásgeir Sigurðsson2, Louis M. Lin2, Bill Kahler3
1Division of Endodontics, Columbia University College of Dental Medicine, New York, NY, USA
2Department of Endodontics, New York University College of Dentistry, New York, NY, USA
3The University of Queensland, School of Dentistry, Brisbane, Australia

Tóm tắt

AbstractThe European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (Dental Traumatology, 17, 2001, 185) and Banchs & Trope (Journal of Endodontics, 30, 2004, 196). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet‐rich fibrin have been utilized in regenerative endodontics. This approach has been described as a ‘paradigm shift’ and considered the first treatment option for immature teeth with pulp necrosis. There are three treatment outcomes of regenerative endodontics; (i) resolution of clinical signs and symptoms; (ii) further root maturation; and (iii) return of neurogenesis. It is known that results are variable for these objectives, and true regeneration of the pulp/dentine complex is not achieved. Repair derived primarily from the periodontal and osseous tissues has been shown histologically. It is hoped that with the concept of tissue engineering, namely stem cells, scaffolds and signalling molecules, that true pulp regeneration is an achievable goal. This review discusses current knowledge as well as future directions for regenerative endodontics. Patient‐centred outcomes such as tooth discolouration and possibly more appointments with the potential for adverse effects needs to be discussed with patients and parents. Based on the classification of Cvek (Endodontics and Dental Traumatology, 8, 1992, 45), it is proposed that regenerative endodontics should be considered for teeth with incomplete root formation although teeth with near or complete root formation may be more suited for conventional endodontic therapy or MTA barrier techniques. However, much is still not known about clinical and biological aspects of regenerative endodontics.

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Tài liệu tham khảo

Abbas AK, 2007, Cellular and Molecular Immunology

10.1046/j.1365-2591.2003.00652.x

10.1016/j.joen.2014.02.016

10.2217/rme.10.30

10.1016/j.joen.2013.11.008

American Association of Endodontists (AAE)(2016)Clinical Considerations for a Regenerative Procedure. Revised 2016.https://www.aae.org/uploadedfiles/publications_and_research/research/currentregenerativeendodonticconsiderations.pdf

10.1111/j.1600-9657.2011.01057.x

10.1093/ejo/12.1.14

10.1034/j.1600-9657.2002.00097.x

10.3109/00016357.2015.1069394

Askari AT, 2003, Stromal cell‐derived factor‐1 mediates stem cell homing and tissue regeneration, Discovery Medicine, 3, 46

10.1016/j.joen.2016.10.016

10.1097/00004770-200404000-00003

10.1177/00220345660450041501

10.1111/j.1524-475X.2008.00410.x

10.1097/00004770-200301000-00012

10.1016/j.joen.2013.07.017

10.1016/j.joen.2014.10.004

10.1016/j.joen.2009.06.021

10.1016/j.joen.2016.06.021

Byström A, 1981, Bacteriologic evaluation of the efficacy of mechanical root canal instrumentation in endodontic therapy, Scandinavian Journal of Dental Research, 89, 321

10.1016/j.tripleo.2011.03.047

10.1016/j.joen.2016.10.035

10.1111/iej.12515

10.1016/j.joen.2017.04.015

10.1016/j.joen.2009.09.017

10.1111/j.1365-2591.2011.01978.x

10.1111/edt.12214

10.1016/j.joen.2016.09.024

10.1016/j.joen.2006.07.010

10.1111/iej.12711

10.1016/j.joen.2008.04.009

10.1111/j.1600-9657.1992.tb00228.x

Cvek M, 1976, Antimicrobial effect of root canal débridement in teeth with immature root. A clinical and microbiologic study, Odontological Revy, 27, 1

10.1016/j.cden.2016.08.004

10.1111/etp.12040

10.1016/j.joen.2016.06.020

Estrela C, 1995, Mechanism of action on calcium hydroxyl ions of calcium hydroxide on tissue and bacteria, Brazilian Dental Journal, 6, 85

10.1590/S1678-77572009000100002

10.1111/iej.12629

10.1111/iej.12781

10.1016/j.joen.2017.10.007

10.1073/pnas.1015449108

10.2174/157488706776876472

10.1016/j.joen.2017.06.010

10.1111/etp.12039

10.14219/jada.archive.1966.0017

10.1016/j.joen.2011.08.027

10.1016/j.joen.2014.11.021

10.1111/iej.12492

Goering R, 2013, Mims’ Medical Microbiology

10.1016/S2352-3026(15)00028-9

10.1073/pnas.240309797

10.14219/jada.archive.1972.0451

10.1111/j.1601-1546.2012.00281.x

10.1046/j.1365-2591.2000.00291.x

10.1111/j.1601-1546.2005.00135.x

10.1016/j.joen.2007.04.008

10.1016/j.joen.2008.02.032

10.1111/j.1365-2591.1975.tb01000.x

10.1093/ageing/26.suppl_4.15

10.1111/j.1365-2591.1996.tb01173.x

10.1016/j.joen.2008.02.009

10.1016/j.joen.2008.03.001

10.1089/ten.tea.2009.0518

10.1089/ten.tea.2010.0615

10.5966/sctm.2012-0132erratum

10.1034/j.1600-9657.2001.017004185.x

10.1016/j.joen.2012.09.010

10.1016/j.joen.2012.06.028

Jones DL, 2008, No place like home: anatomy and function of stem cell niches, Molecular Cell Biology, 9, 11

10.1016/j.joen.2015.12.022

10.1016/j.joen.2013.10.032

10.1016/j.joen.2017.03.003

10.1016/j.joen.2017.09.018

10.1016/j.joen.2008.10.004

10.1016/j.stem.2009.02.001

10.1111/iej.12107

Kim SG, 2016, Infection and pulp regeneration. Dentistry Journal, 4, 4

10.1016/j.cden.2016.08.005

10.1089/ten.tea.2010.0181

10.1016/j.cden.2012.05.001

10.1111/etp.12037

10.1111/iej.12423

10.1002/art.24330

10.1016/j.joen.2015.08.021

10.1111/j.1600-9657.1986.tb00132.x

10.1016/j.joen.2014.03.013

10.1016/j.joen.2014.08.003

Kumar V, 2015, Robbins and Cotran Pathologic Basis of Disease

10.1016/j.joca.2008.11.011

10.1016/j.joen.2013.02.004

10.1016/j.joen.2015.03.012

10.1146/annurev.cellbio.21.012704.131525

10.1242/dev.137216

10.1016/j.joen.2011.05.022

10.1111/j.1365-2591.2011.01915.x

10.1016/j.joen.2013.08.024

10.1016/j.joen.2017.06.023

10.1111/aej.12252

10.1111/iej.12705

10.1111/iej.12551

10.3109/09537104.2015.1131255

10.1016/j.joen.2010.10.009

10.1016/S0966-842X(00)01913-2

Majno G, 2004, Cells, Tissues, and Disease

10.1016/j.joen.2015.10.013

10.1242/dev.01253

10.1016/j.joen.2012.09.015

10.1016/j.joen.2013.07.026

10.1111/iej.12344

10.4103/0976-237X.118379

10.1177/154405910408301202

10.1073/pnas.0937635100

10.1111/j.1875-595X.2008.tb00354.x

10.1111/j.1365-2591.2011.01886.x

10.4103/1305-7456.119091

10.1126/science.1110542

10.1016/j.joen.2006.09.013

10.1016/0030-4220(74)90119-4

10.1016/j.joen.2014.01.038

10.1016/j.joen.2013.10.027

10.1097/01.don.0000164138.49923.e5

10.1186/s13287-017-0506-5

Nanci A, 2007, Ten Cate's Oral Biology

10.4103/0976-237X.149294

10.1016/S0099-2399(76)80058-1

10.1016/j.joen.2012.06.025

10.1016/j.joen.2013.06.019

10.1016/j.joen.2015.05.004

Nygaard‐Ostby B, 1961, The role of the blood in endodontic therapy. An experimental histological study, Acta Odontologica Scandinavia, 19, 324

Nygarrd‐Ostby B, 1971, Tissue formation in the root canal following pulp removal, Scandinavian Journal of Dental Research, 79, 333

10.1016/j.joen.2009.09.009

10.1002/stem.1517

10.1128/AEM.01078-12

10.1016/j.joen.2009.10.006

10.1038/mt.2011.211

10.1111/j.1600-9657.2004.00284.x

10.1111/edt.12189

10.1016/j.jdent.2016.10.005

Roilides E, 2015, How biofilms evade host defense, Microbiology Spectrum, 3, 3, 10.1128/microbiolspec.MB-0012-2014

10.1177/0022034513505772

10.1016/j.joen.2012.06.018

10.1089/wound.2011.0314

Rybak MJ, 1996, Combination antimicrobial therapyfor bacterial infection, Guidelines for the clinicians. Drugs, 52, 390

10.1016/S0099-2399(06)81199-4

10.1016/j.joen.2014.08.023

10.1111/edt.12169

10.1016/j.joen.2016.04.028

10.1111/j.1365-2591.2006.01197.x

10.1111/j.1365-2591.1996.tb01172.x

10.1038/nature04957

10.1111/j.1365-2591.2006.01161.x

10.1016/j.joen.2013.04.032

10.1111/j.1365-2591.2009.01633.x

10.4103/0972-0707.101926

10.1016/j.joen.2015.08.034

10.1016/j.joen.2016.10.030

10.1016/j.tripleo.2009.12.046

10.1016/j.joen.2014.01.024

10.1146/annurev-pathol-011110-130230

10.1046/j.1365-2591.1999.00275.x

10.1111/j.1365-2591.1991.tb00117.x

10.1016/S0099-2399(81)80097-0

10.1016/0030-4220(78)90217-7

10.1016/j.joen.2017.06.002

10.1016/j.archoralbio.2011.07.008

10.1016/j.joen.2017.06.018

10.1016/j.joen.2007.11.021

10.1046/j.1365-2591.2001.00392.x

10.1016/S0039-6109(05)70569-7

10.1016/S0140-6736(01)05321-1

Strindberg LZ, 1956, The dependence of the results of pulp therapy on certain factors: an analytic study based on radiographic and clinical follow‐up examinations, Acta Odontogenica Scandinavian, 14, 1

10.1111/j.1601-1546.2004.00112.x

10.1016/j.joen.2007.03.001

10.1016/j.joen.2017.04.018

10.1016/j.joen.2016.06.005

10.1016/j.joen.2010.11.004

10.1016/j.joen.2013.12.025

10.1016/j.joen.2017.06.029

Toubes KMS, 2017, Clinical approach to pulp canal obliteration: a case series, Iranian Endodontic Journal, 12, 527

10.1016/j.joen.2011.05.013

10.1016/j.joen.2017.06.013

10.1016/j.joen.2010.02.006

10.1016/j.joen.2017.01.023

10.1016/j.stem.2012.02.018

10.1016/j.joen.2009.09.039

10.1159/000471865

10.1152/physrev.2003.83.3.835

10.1097/01.don.0000148143.80283.ea

10.1111/edt.12168

10.1016/j.joen.2011.08.025

10.1016/j.biomaterials.2014.12.006

10.1016/j.joen.2016.08.020

10.1016/j.joen.2005.09.014

10.1111/cpr.12361

10.1016/j.joen.2017.07.021

10.1016/j.joen.2015.08.026

10.1016/j.joen.2016.02.004