Redox state alters anti‐cancer effects of wedelolactone
Tóm tắt
Wedelolactone is one of the active plant polyphenolic compounds. Anti‐tumor effects of this drug have been demonstrated recently. We have described that wedelolactone acts as catalytic inhibitor of DNA topoisomerase IIα. The aim of this study was to further characterize the mechanism of its anti‐tumor effects. We showed that wedelolactone inhibits binding of DNA topoisomerase IIα to plasmid DNA and antagonizes formation of etoposide‐induced DNA cleavage complex. The inhibition of topoisomerase IIα by wedelolactone is reversible by excess of the enzyme but not DNA. The
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Tài liệu tham khảo
Bechtel W, 2009, Catalase protects tumor cells from apoptosis induction by intercellular ROS signaling, Anticancer Res, 29, 4541
Danilewicz JC, 2003, Review of reaction mechanisms of oxygen and proposed intermediate reduction products in wine: Central role of iron and copper, Am J Enol Vitic, 54, 73, 10.5344/ajev.2003.54.2.73