Recombinant congenic strains of mice from B10.D2 and DBA/2: Their contribution to behavior genetic research and application to audiogenic seizures
Tóm tắt
Recombinant congenic strains (RCS) represent a series of related strains, each of which carries a small fraction of the genome of one strain (“donor” strain) on the genetic background of another strain (“background” strain). Recombinant inbred strains (RIS) are commonly used to identify major gene segregation and linkage and associations between behavior and quantitative trait loci, whereas recombinant congenic strains (RCS) open other complementary leads. The variability in the reactivity of RCS to a trait is thus the expression of few minor-effect genes originating from the donor strain, because the probability that major genes are present in any one RCS is low. Unlike RIS in which minor-effect genes are often masked by major genes, RCS enable the effects of minor genes to be studied. With our method, for a given trait, an estimate can be made of the gene strength distribution as well as an estimate of the minimal number of genes involved having a certain strength.
Tài liệu tham khảo
Bailey, D. W. (1971). Recombinant inbred strains, an aid to finding identity, linkage and function of histocompatibility and other genes.Transplantation 11:325–327.
Bailey, D. W. (1981). Recombinant inbred strains and bilineal congenic strains, In Foster, H. L., Small, J. D., and Fox, J. G. (eds.),The Mouse in Biomedical Research, Academic Press, New York, pp. 223–240.
Bonhomme, F., and Selander, R. K. (1978). Estimating total genic diversity in the house mouse.Biochem. Genet. 16:287–298.
Démant, P. (1989). Genetics of tumor susceptibility in the mouse: MHC and non-MHC genes.Adv. Cancer Res. 53:117–179.
Démant, P., and Hart, A. (1986). Recombinant congenic strains—a new tool for analysing genetic traits determined by more than one gene.Immunogenetics 24:416–422.
Halle-Pannenko, O., Motta, R., and Mathe, G. (1983).Pgm-1 marker linked (non-H-2) gene(s) decrease(s) lethal GVHR developed againstH-2 antigens.Transplant. Proc. 15:1458–1462.
Halle-Pannenko, O., Pritchard, L. L., Bruley-Rosset, M., Berumen, L., and Motta, R. (1985). Parameters involved in the induction and abrogation of the graft-versus-host reaction directed non-H-2 antigens.Immunol. Rev. 88:59–85.
Halle-Pannenko, O., Mary, J. Y., and Motta, R. (1986). Sex-dependent effects of non-H-2 loci on lethal GVH reaction induced across an H-2 barrier.Immunogenetics 24:217–224.
Motta, R., Desgrousilliers, A., and Spach, C. (1980). Histocompatibilité mineure chez la souris.Symbioses 12:251–276.
Motta, R., and Spach, C. (1992). Strong allelic selection in the course of brotherxsister matings in mice.J. Hered. (in press).
Motta, R., Moutier, R., and Halle-Pannenko, O. (1981). Minor histocompatibility genes important in lethal graft-versus-host reaction (GVHR): Chromosomal assignment of five genes using ten chromosomal markers.Transplant. Proc. 13:1207–1214.
Motta, R., Spach, C., Desgrousilliers, A., Moutier, R., Bertrand, M.-F., Leloup, P., Motta, G., Bureaud, N., Gonzalez, M.-C., Gille, F., and Annicolas, D. (1987). Création de 36 souches congéniques recombinantes (C.R.) entre B10.D2 et DBA/2.Sci. Tech. Anim. Lab. 12:5–17.
Motta, R., Spach, C., Annicolas, D., Bertrand, M.-F., Bureaud, N., Desgrousilliers, A., Gille, F., Gonzalez, M.-C., Leloup, P., Motta, G., and Moutier, R. (1989). Thirty-six recombinant congenic inbred mouse strains between B10.D2 and DBA/2 strains carrying about 99% and 1% of the genetic background of each parent, respectively.Mouse News Lett. 85:11.
Nadeau, J. H., Hermann, B., Bucan, M., Burkart, D., Crosby, J. L., Erhart, M. A., Kosowsky, M., Kraus, J. P., Michiels, F., Schnattinger, A., Tchetgen, M.-B., Varnum, D., Willison, K., Lehrach, H., and Barlow, D. (1991). Genetic maps of mouse chromosome 17 including 12 new anonymous DNA loci and 25 anchor loci.Genomics 9:78–89.
Neumann, P. E., and Collins, R. L. (1991). Genetic dissection of susceptibility to audiogenic seizures in inbred mice.Proc. Natl. Acad. Sci. USA 88:5408–5412.
Neumann, P. E., and Collins, R. L. (1991). Genetic dissection of susceptibility to audiogenic seizures in inbred mice.Proc. Natl. Acad. Sci. USA 88:5408–5412.
Neumann, P. E., and Seyfried, T. N. (1990). Mapping of two genes that influence susceptibility to audiogenic seizures in crosses of C57BL/6J and DBA/2J mice.Behav. Genet. 20:307–323.
Peters, J., and Lewis, S. E. (1991). Electrophoretic variation in multiple recessive tester,T, stock mice.Mutat. Res. 249:323–330.
Roubertoux, P., Nosten, M., and Carlier, M. (1990). Additive and interactive effects of genotype and maternal environments.Adv. Study Behav. 19:205–247.
Taylor, B. A. (1981). Recombinant inbred strains, In Green, M. C. (ed.),Genetic Variants and Strains of the Laboratory Mice, Gustav Fischer Verlag, New York, pp. 397–407.