Recombinant Human Foamy Virus, a Novel Vector for Neurological Disorders Gene Therapy, Drives Production of GAD in Cultured Astrocytes

Thomas, 2003, Progress and problems with the use of viral vectors for gene therapy, Nat Rev Genet, 4, 346, 10.1038/nrg1066 Mergia, 2003, Foamy virus vectors, Curr Top Microbiol Immunol, 277, 131 Flugel, 1991, Spumaviruses: a group of complex retrovirus, J Acquir Immune Defic Syndr, 4, 739 Linial, 2000, Why aren't foamy viruses pathogenic?, Trends Microbiol, 8, 284, 10.1016/S0966-842X(00)01763-7 Weiss, 1988, Foamy retroviruses. A virus in search of a disease, Nature, 333, 497, 10.1038/333497a0 Heneine, 1998, Identification of a human population infected with simian foamy viruses, Nat Med, 4, 403, 10.1038/nm0498-403 Schweizer, 1995, Markers of foamy virus infections in monkeys, apes, and accidentally infected humans: appropriate testing fails to confirm suspected foamy virus prevalence in humans, AIDS Res Hum Retroviruses, 11, 161, 10.1089/aid.1995.11.161 Schweizer, 1997, Simian foamy virus isolated from an accidentally infected human individual, J Virol, 71, 4821, 10.1128/JVI.71.6.4821-4824.1997 Wolfe, 2004, Naturally acquired simian retrovirus infections in central African hunters, Lancet, 363, 932, 10.1016/S0140-6736(04)15787-5 Trobridge, 2006, Foamy virus vector integration sites in normal human cells, Proc Natl Acad Sci USA, 103, 1498, 10.1073/pnas.0510046103 Lochelt, 1993, Human foamy virus genome possesses an internal Bel-1-dependent and functional promoter, Proc Natl Acad Sci USA, 90, 7317, 10.1073/pnas.90.15.7317 Trobridge, 2002, Improved foamy virus vectors with minimal viral sequences, Mol Ther, 6, 321, 10.1006/mthe.2002.0672 Russell, 1996, Foamy virus vectors, J Virol, 70, 217, 10.1128/JVI.70.1.217-222.1996 Hill, 1999, Properties of human foamy virus relevant to its development as a vector for gene therapy, J Gen Virol, 80, 2003, 10.1099/0022-1317-80-8-2003 Liu, 2005, Efficient therapeutic gene expression in cultured rat hippocampal neurons mediated by human foamy virus vectors: a potential for the treatment of neurological diseases, Intervirology, 48, 329, 10.1159/000085102 Josephson, 2004, Transduction of long-term and mobilized peripheral blood-derived NOD/SCID repopulating cells by foamy virus vectors, Hum Gene Ther, 15, 87, 10.1089/10430340460732481 Martin, 1991, Cofactor interactions and the regulation of glutamate decarboxylase activity, Neurochem Res, 16, 243, 10.1007/BF00966087 Schousboe, 2006, Glial modulation of GABAergic and glutamat ergic neurotransmission, Curr Top Med Chem, 6, 929, 10.2174/156802606777323719 Bu, 1992, Two human glutamate decarboxylases, 65-kDa and 67-kDa GAD, are each encoded by a single gene, Proc Natl Acad Sci USA, 89, 2115, 10.1073/pnas.89.6.2115 Mergia, 2001, The efficiency of simian foamy virus vector type-1 (SFV-1) in nondividing cells and in human PBLs, Virology, 280, 243, 10.1006/viro.2000.0773 Saib, 1997, Nuclear targeting of incoming human foamy virus Gag proteins involves a centriolar step, J Virol, 71, 1155, 10.1128/JVI.71.2.1155-1161.1997 Lundberg, 1996, Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxylase gene: in vitro characterization and in vivo effects in the rat Parkinson model, Exp Neurol, 139, 39, 10.1006/exnr.1996.0079 Snyder, 1997, The use of nonneuronal cells for gene delivery, Neurobiol Dis, 4, 69, 10.1006/nbdi.1997.0138 Ridet, 2003, Transplantation of human adult astrocytes: efficiency and safety requirements for an autologous gene therapy, J Neurosci Res, 72, 704, 10.1002/jnr.10617 Mausset-Bonnefont, 2003, Immunohistochemistry as a tool for topographical semi-quantification of neurotransmitters in the brain, Brain Res Protoc, 10, 148, 10.1016/S1385-299X(02)00206-4 Schousboe, 1992, Regulatory role of astrocytes for neuronal biosynthesis and homeostasis of glutamate and GABA, Prog Brain Res, 94, 199, 10.1016/S0079-6123(08)61751-3 Bak, 2006, The glutamate/GABA-glutamine cycle: aspects of transport, neurotransmitter homeostasis and ammonia transfer, J Neurochem, 98, 641, 10.1111/j.1471-4159.2006.03913.x Borden, 1996, GABA transporter heterogeneity: pharmacology and cellular localization, Neurochem Int, 29, 335, 10.1016/0197-0186(95)00158-1 Fraser, 1994, Astrocytic GABA receptors, Glia, 11, 83, 10.1002/glia.440110203 Roe, 1993, Intergration of murine leukemia virus DNA depends on mitosis, EMBO J, 12, 2099, 10.1002/j.1460-2075.1993.tb05858.x Lewis, 1994, Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus, J Virol, 68, 510, 10.1128/JVI.68.1.510-516.1994 Hacein-Bey-Abina, 2003, A serious adverse event after successful gene therapy for X-linked severe combined immunodeficiency, N Engl J Med, 348, 255, 10.1056/NEJM200301163480314 Mi, 1999, Recombinant adeno-associated virus (AAV) drives constitutive production of glutamate decarboxylase in neural cell lines, J Neurosci Res, 57, 137, 10.1002/(SICI)1097-4547(19990701)57:1<137::AID-JNR15>3.0.CO;2-D Fritz, 1997, Gene-based neurotransmitter modulation in cerebellar granule neurons, J Neurochem, 68, 204, 10.1046/j.1471-4159.1997.68010204.x Srinivasan, 1969, The effect of electrical stimulation and high potassium concentrations on the efflux of [3H]gamma-aminobutyric acid from brain slices, J Neurochem, 16, 1235, 10.1111/j.1471-4159.1969.tb05971.x Levy, 1973, Stimulus-coupled secretion of gamma-aminobutyric acid from rat brain synaptosomes, Science, 181, 676, 10.1126/science.181.4100.676 Roberts, 1974, Amino acid release from isolated rat dorsal root ganglia, Brain Res, 74, 327, 10.1016/0006-8993(74)90586-1 Minchin, 1974, Release of [3H]gamma-aminobutyric acid from glial cells in rat dorsal root ganglia, J Neurochem, 23, 535, 10.1111/j.1471-4159.1974.tb06056.x Borden, 1995, Re-evaluation of GABA transport in neuronal and glial cell cultures: correlation of pharmacology and mRNA localization, Receptors Channels, 3, 129 Pasantes-Morales, 1989, Release of taurine from astrocytes during potassium-evoked swelling, Glia, 2, 45, 10.1002/glia.440020105 Rutledge, 1996, Release of [3H]-D-aspartate from primary astrocyte cultures in response to raised external potassium, J Neurosci, 16, 7803, 10.1523/JNEUROSCI.16-24-07803.1996 Erlander, 1991, Two genes encode distinct glutamate decarboxylases, Neuron, 7, 91, 10.1016/0896-6273(91)90077-D Belhage, 1993, Depolarization by K+ and glutamate actives different neurotransmitter release mechanisms in GABAergic neurons: vesicular versus non-vesicular release of GABA, Neuroscience, 54, 1019, 10.1016/0306-4522(93)90592-4 Ridet, 1999, Toward autologous ex vivo gene therapy for the central nervous system with human adult astrocytes, Hum Gene Ther, 10, 271, 10.1089/10430349950019057 Li, 2002, Construction of replication-defective human foamy virus vector directing expression of foreign genes, Virol Sin, 17, 114 Zhang, 2003, Construction of replication-defective virus vector helper plasmid pΔGP and co-transfection to HIC cell, J. Wuhan Univ (Nat Sci Ed), 49, 756 Li, 2002, A new indicator cell line to monitor human foamy virus infection and stability in vitro, Intervirology, 45, 79, 10.1159/000063232 Koyama, 1993, Endothelins modulate dibutyryl cAMP-induced stellation of cultured astrocytes, Brain Res, 600, 81, 10.1016/0006-8993(93)90404-B Bourdelais, 1991, High sensitivity HPLC assay for GABA in brain dialysis studies, J Neurosci Methods, 29, 115, 10.1016/0165-0270(91)90077-D