Recent advances on blinatumomab for acute lymphoblastic leukemia

Experimental Hematology & Oncology - Tập 8 Số 1 - 2019
Juanjuan Zhao1, Yongping Song1, Delong Liu2
1Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, China
2Department of Medicine, New York Medical College and Westchester Medical Center, Valhalla, NY, 10595, USA

Tóm tắt

Abstract Although complete remission rate of B cell acute lymphoblastic leukemia (B-ALL) has improved significantly over the past few decades, patients with relapsed/refractory ALL still have dismal outcome. Tyrosine kinase inhibitors, antibody–drug conjugates and chimeric antigen receptor T cell therapy are changing the therapy landscape for B- ALL. Blinatumomab, a bi-specific T cell engager, has been approved for patients with relapsed/refractory and minimal residual disease positive B-ALL. This review summarized data from recent clinical trials of blinatumomab for B-ALL treatment.

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