Realgar‐induced differentiation is associated with MAPK pathways in HL‐60 cells

Cell Biology International - Tập 32 - Trang 1497-1505 - 2008
Nan Wang1, Li-Wen Wang2, Bao-Di Gou1, Tian-Lan Zhang1,2, Kui Wang1
1Department of Chemical Biology, Peking University School of Pharmaceutical Sciences, 38 Xueyuan Road, Beijing 100083, PR China
2Department of Chemical Biology, Capital Medical University School of Pharmaceutical Sciences, 10 Xitoutiao, You An Men, Beijing 100069, PR China

Tóm tắt

AbstractThe clinical efficacy and safety of realgar (arsenic sulfide, As4S4) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL‐60 cells. Treatment with RNPs at 6 μM for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP‐induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP‐induced differentiation in HL‐60 cells.

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Thông tin xuất bản

Cell Biology International

Tập 32

1497-1505

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