Sự tái xuất hiện của virus mayaro và đồng nhiễm với chikungunya trong một đợt bùng phát tại bang Tocantins/Brazil

Robson dos Santos Souza Marinho1, Rodrigo Lopes Sanz Duro1, Débora Bellini Caldeira1, Juliana Galinskas1, Mânlio Tasso Oliveira Mota1, James R. Hunter1, Maria da Aparecida Rodrigues Teles2, Flávio Augusto de Pádua Milagres2, Ricardo Sobhie Diaz1, Fernando Shinjí Kawakubo3, Shirley Vasconcelos Komninakis4
1Retrovirology Laboratory, Federal University of São Paulo, São Paulo City, São Paulo, 04039-032, Brazil
2Central Public Health Laboratory of Tocantins (LACEN/TO), Palmas City, Tocantins, 77016-330, Brazil
3Faculty of Philosophy, Letters and Human Sciences, University of São Paulo, São Paulo City, São Paulo, 05508-000, Brazil
4Faculty of Medicine (FMUSP), Institute of Tropical Medicine, University of São Paulo, São Paulo City, São Paulo, 05403-000, Brazil

Tóm tắt

Tóm tắt Mục tiêu Thực hiện sàng lọc phân tử để phát hiện nhiễm virus mayaro và khả năng đồng nhiễm với Chikungunya trong một đợt bùng phát tại bang Tocantins/Brazil vào năm 2017. Kết quả Trong tổng số 102 mẫu được phân tích trong nghiên cứu này, đã xác định được 6 trường hợp nhiễm đồng thời giữa virus mayaro và chikungunya (5,88%). Trong 6 mẫu này, giá trị trung bình của ngưỡng chu kỳ (Ct) cho CHIKV là 26.87 (SD ± 10.54) và cho MAYV là 29.58 (SD ± 6.34). Các chuỗi gene của virus mayaro được tạo ra cho thấy sự đồng nhất 95–100% với các chuỗi khác của virus này tại Brazil và với các chủng MAYV khác thu được từ người và côn trùng ở các khu vực khác nhau trên thế giới. Các mẫu còn lại được phát hiện nhiễm đơn với CHIKV (41 trường hợp), nhiễm đơn với DENV (50 trường hợp) và đồng nhiễm giữa CHIKV/DENV (5 trường hợp). Chúng tôi đã không phát hiện được nhiễm đơn với MAYV.

Từ khóa


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