Radiation-related genomic profile of papillary thyroid carcinoma after the Chernobyl accident

American Association for the Advancement of Science (AAAS) - Tập 372 Số 6543 - 2021
Lindsay M. Morton1, Danielle M. Karyadi2, Chip Stewart3, Bogdanova Ti4, Eric T. Dawson2,5, Mia Steinberg6, Jieqiong Dai6, Stephen W. Hartley2, Sara J. Schonfeld1, Joshua N. Sampson7, Yosef E. Maruvka3, Vidushi Kapoor6, Dale A. Ramsden8, Juan Carvajal-Garcia9, Charles M. Perou10,11, Joel S. Parker10, Marko Krznarić12, Meredith Yeager6, Joseph F. Boland6, Amy Hutchinson6, Belynda Hicks6, Casey Dagnall6, Julie M. Gastier‐Foster13, Jay Bowen14, Olivia W. Lee2, Mitchell J. Machiela15, Elizabeth K. Cahoon1, Alina V. Brenner16, Kiyóhiko Mabuchi1, Vladimir Drozdovitch1, Sergii Masiuk17, Mykola Chepurny17, Liudmyla Zurnadzhy4, Maureen Hatch1, Amy Berrington de González1, Gerry Thomas12, М.D. Тronko18, Gad Getz3,19,20, Stephen J. Chanock2
1Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
2Laboratory of Genetic Susceptibility, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
3Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA
4Laboratory of Morphology of the Endocrine System, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.
5NVIDIA Corporation, Santa Clara, CA 95051, USA
6Cancer Genomics Research Laboratory, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Bethesda, MD 20892, USA.
7Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
8Department of Biochemistry and Biophysics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.
9Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA
10Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA.
11Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
12Department of Surgery and Cancer, Imperial College London, Charing Cross Hospital, London W6 8RF, UK.
13Departments of Pathology and Pediatrics, Ohio State University College of Medicine, Columbus, OH 43210, USA.
14Nationwide Children’s Hospital, Biospecimen Core Resource, Columbus, OH 43205, USA.
15Integrative Tumor Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA.
16Radiation Effects Research Foundation, Hiroshima 732-0815, Japan.
17Radiological Protection Laboratory, Institute of Radiation Hygiene and Epidemiology, National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine, Kyiv 04050, Ukraine.
18Department of Fundamental and Applied Problems of Endocrinology, V. P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv 04114, Ukraine.
19Center for Cancer Research and Department of Pathology, Massachusetts General Hospital, Boston, MA 02114, USA.
20Harvard Medical School Boston, MA 02115 USA

Tóm tắt

Genomics of radiation-induced damage The potential adverse effects of exposures to radioactivity from nuclear accidents can include acute consequences such as radiation sickness, as well as long-term sequelae such as increased risk of cancer. There have been a few studies examining transgenerational risks of radiation exposure but the results have been inconclusive. Morton et al. analyzed papillary thyroid tumors, normal thyroid tissue, and blood from hundreds of survivors of the Chernobyl nuclear accident and compared them against those of unexposed patients. The findings offer insight into the process of radiation-induced carcinogenesis and characteristic patterns of DNA damage associated with environmental radiation exposure. In a separate study, Yeager et al. analyzed the genomes of 130 children and parents from families in which one or both parents had experienced gonadal radiation exposure related to the Chernobyl accident and the children were conceived between 1987 and 2002. Reassuringly, the authors did not find an increase in new germline mutations in this population. Science , this issue p. eabg2538 , p. 725

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American Association for the Advancement of Science (AAAS)

Tập 372 Số 6543

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