RP-HPLC determination of lipophilicity in series of quinoline derivatives

Central European Journal of Chemistry - Tập 7 - Trang 586-597 - 2009
Robert Musiol1, Josef Jampilek2,3, Barbara Podeszwa1, Jacek Finster1, Dominik Tabak1, Jiri Dohnal2,3, Jaroslaw Polanski1
1Institute of Chemistry, University of Silesia, Katowice, Poland
2Zentiva a.s., Prague 10, Czech Republic
3Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic

Tóm tắt

In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds.

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