REVIEW ARTICLE: The Immune System in Pregnancy: A Unique Complexity
Tóm tắt
Placental immune response and its tropism for specific viruses and pathogens affect the outcome of the pregnant woman’s susceptibility to and severity of certain infectious diseases. The generalization of pregnancy as a condition of immune suppression or increased risk is misleading and prevents the determination of adequate guidelines for treating pregnant women during pandemics. There is a need to evaluate the interaction of each specific pathogen with the fetal/placental unit and its responses to design the adequate prophylaxis or therapy. The complexity of the immunology of pregnancy and the focus, for many years, on the concept of immunology of pregnancy as an organ transplantation have complicated the field and delayed the development of new guidelines with clinical implications that could help to answer these and other relevant questions. Our challenge as scientists and clinicians interested in the field of reproductive immunology is to evaluate many of the ‘classical concepts’ to define new approaches for a better understanding of the immunology of pregnancy that will benefit mothers and fetuses in different clinical scenarios.
Từ khóa
Tài liệu tham khảo
Mor G, 2006, Macrophage–trophoblast interactions, Methods Mol Med, 122, 149
Birnberg T, 2007, Dendritic cells are crucial for decidual development during embryo implantation, Am J Reprod Immunol, 57, 342
Collins MK, 2009, Dendritic cell entrapment within the pregnant uterus inhibits immune surveillance of the maternal/fetal interface in mice, J Clin Invest, 119, 2062
Medawar PB, 1948, Immunity to homologous grafted skin. III. The fate of skin homografts transplanted to the brain, to subcutaneous tissue, and to the anterior chamber of the eye, Br J Exp Pathol, 29, 58
Medawar P, 1952, Some immunological and endocrinological problems raised by the evolution of viviparity in vertebrates, Symp Soc Exp Biol, 7, 320
Mor G, 2007, Pregnancy reconceived, Nat Hist, 116, 36
Wegmann T, 1984, Fetal protection against abortion: is it immunosupression or immunostimulation?, Ann Immunol, 135, 309
Mor G, 2002, Immunology and Allergy Clinics, 545
Romero R, 2005, Novel aspects of neutrophil biology in human pregnancy, Am J Reprod Immunol, 53, 275
Mel’nikova VF, 1993, [Infectious placentitis and characterization of the placenta as an immune barrier], Arkh Patol, 55, 78
Cardenas I, 2009, Subclinical viral infection in pregnancy lead to inflammatory process at the placenta with non‐lethal fetal damage, Am J Reprod Immunol, 61, 397