RESEARCH ON PLASMA ERYTHROPOIETIN CONCENTRATION IN TYPE 2 DIABETIC PATIENTS WITH KIDNEY INJURY

Objectives: To investigate plasma erythropoietin (EPO) concentration and its relationship with some characteristics in type 2 diabetic patients (T2DM) with chronic kidney injury (CKI). Subjects and methods: A cross-sectional descriptive study on 219 subjects, including 129 patients with type 2 diabetes with chronic kidney injury, 51 patients with diabetes without CKI as a disease control group, and 39 healthy people as a normal control group. All subjects had their plasma EPO levels quantified by ELISA. Results: The median EPO concentration of the research group was 35.83 (21.55 - 56.34) UI/L, lower than the disease control group, which was 44.72 (37.25 - 63.90) UI/L, and lower than the normal control group, which was 113.31 (30.55 - 378.42) UI/L, p < 0.001. The rate of EPO reduction in the study group was 41.9%. EPO concentration was positively correlated with GFR, r = 0.242, p < 0.01. Creatinine is an independent factor associated with reduced EPO, p < 0.05. Conclusion: The rate of EPO reduction in the type 2 DM group with CKI was 41.9%. Decreases in EPO levels are common in KI patients with type 2 diabetes and are associated with decreased GFR.