Régulation hormonale et nutritionnelle du système mélanocortinergique hypothalamique

Coll AP, Loraine Tung YC. Pro-opiomelanocortin (POMC)-derived peptides and the regulation of energy homeostasis. Mol Cell Endocrinol 2008, in press. Dhillo, 2007, Appetite regulation: an overview, Thyroid, 17, 433, 10.1089/thy.2007.0018 Wikberg, 2008, Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction, Nat Rev, 7, 307 Cone, 2005, Anatomy and regulation of the central melanocortin system, Nat Neurosci, 8, 571, 10.1038/nn1455 Schwartz, 2000, Central nervous system control of food intake, Nature, 404, 661, 10.1038/35007534 Zheng, 2005, Brain stem melanocortinergic modulation of meal size and identification of hypothalamic projections, Am J Physiol Regul Integr Comp Physiol, 289, R247, 10.1152/ajpregu.00869.2004 Coll, 2007, The hormonal control of food intake, Cell, 129, 251, 10.1016/j.cell.2007.04.001 Schwartz, 1997, Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus, Diabetes, 46, 2119, 10.2337/diab.46.12.2119 Gout, 2008, Leptin infusion and obesity in mouse cause alterations in the hypothalamic melanocortin system, Obesity, 16, 1763, 10.1038/oby.2008.303 Enriori, 2007, Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons, Cell Metab, 5, 181, 10.1016/j.cmet.2007.02.004 Harrold, 1999, Altered energy balance causes selective changes in melanocortin-4 (MC4-R) but not melanocortin-3 (MC3-R) receptors in specific hypothalamic regions. Further evidence that activation of MC4-R is a physiological inhibitor of feeding, Diabetes, 48, 267, 10.2337/diabetes.48.2.267 Sipols, 1995, Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression, Diabetes, 44, 147, 10.2337/diab.44.2.147 Drazen, 2003, Adrenalectomy alters the sensitivity of the central nervous melanocortin system, Diabetes, 52, 2928, 10.2337/diabetes.52.12.2928 Makimura, 2003, Role of glucocorticoid in mediating effects of fasting and diabetes on hypothalamic gene expression, BMC Physiology, 3, 1, 10.1186/1472-6793-3-1 Olszewski, 2007, Alpha-melanocyte stimulating hormone and ghrelin: central interaction in feeding control, Peptides, 28, 2084, 10.1016/j.peptides.2007.07.017 Charbonneau, 2004, Central and peripheral interactions between the agouti-related protein and leptin, Biochem Biophys Res Commun, 319, 518, 10.1016/j.bbrc.2004.05.022 Muroya, 1999, Glucose-sensitive neurons in the rat arcuate nucleus contain neuropeptide Y, Neurosci Lett, 264, 113, 10.1016/S0304-3940(99)00185-8 Ibrahim, 2003, Hypothalamic proopiomelanocortin neurons are glucose responsive and express K (ATP) channels, Endocrinology, 144, 1331, 10.1210/en.2002-221033 Parton, 2007, Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity, Nature, 449, 228, 10.1038/nature06098 Wang, 2004, The regulation of glucose-excited neurons in the hypothalamic arcuate nucleus by glucose and feeding-relevant peptides, Diabetes, 53, 1959, 10.2337/diabetes.53.8.1959 Fioramonti, 2007, Characterization of glucosensing neuron subpopulations in the arcuate nucleus. Integration in neuropeptide Y and pro-opiomelanocortin networks, Diabetes, 56, 1219, 10.2337/db06-0567 Pénicaud, 2006, Brain glucose sensing: a subtle mechanism, Curr Opin Clin Nutr Metab Care, 9, 458, 10.1097/01.mco.0000232908.84483.e0 Marty, 2007, Brain glucose sensing, counterregulation, and energy homeostasis, Physiology, 22, 241, 10.1152/physiol.00010.2007 Ma, 2008, Glucose regulates the effects of leptin on hypothalamic POMC neurons, PNAS, 105, 9811, 10.1073/pnas.0800952105 Chau-Van, 2007, Metformin inhibits adenosine 5′-monophosphate-activated kinase activation and prevents increases in neuropeptide Y expression in cultured hypothalamic neurons, Endocrinology, 148, 507, 10.1210/en.2006-1237 Li, 2006, Overexpression of glucose transporter 2 in GT1-7 cells inhibits AMP-activated protein kinase and agouti-related peptide expression, Brain Res, 1118, 1, 10.1016/j.brainres.2006.08.032 Loftus, 2000, Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors, Science, 288, 2379, 10.1126/science.288.5475.2379 Morgan, 2004, Hypothalamic responses to long-chain fatty acids are nutritionally regulated, J Biol Chem, 279, 31139, 10.1074/jbc.M400458200 Wang, 2006, Effects of oleic acid on distinct populations of neurons in the hypothalamic arcuate nucleus are dependent on extracellular glucose levels, J Neurophysiol, 148, 1491, 10.1152/jn.00697.2005 Perello, 2007, Differential Effects of fasting and leptin on pro-opiomelanocortin peptides in the arcuate nucleus and the nucleus of the solitary tract, Am J Physiol Endocrinol Meta, 292, E1348, 10.1152/ajpendo.00466.2006 Fekete, 2006, Differential effects of central leptin, insulin or glucose administration during fasting on the hypothalamic-pituitary-thyroid axis and feeding-related neurons in the arcuate nucleus, Endocrinology, 147, 520, 10.1210/en.2005-0956 Wang, 2002, Effects of dietary fat types on body fatness, leptin and ARC leptin receptor, NPY and AgRP mRNA expression, Am J Physiol Endocrinol Metab, 282, E1352, 10.1152/ajpendo.00230.2001 Archer, 2007, Solid and liquid obesogenic diets induce obesity and counter-regulatory changes in hypothalamic gene expression in juvenile Sprague-Dawley rats, J Nutr, 137, 1483, 10.1093/jn/137.6.1483 Ziotopoulou, 2000, Differential expression of hypothalamic neuropeptides in the early phase of diet-induced obesity in mice, Am J Physiol Endocrinol Metab, 279, E838, 10.1152/ajpendo.2000.279.4.E838 Mithieux, 2005, Portal sensing of intestinal gluconeogenesis is a mechanistic link in the diminution of food intake induced by diet protein, Cell Metab, 2, 321, 10.1016/j.cmet.2005.09.010 Faipoux, 2008, Proteins activate satiety-related neuronal pathways in the brainstem and hypothalamus of rats, J Nutr, 138, 1172, 10.1093/jn/138.6.1172