Quercitrin a bioflavonoid improves the antioxidant status in streptozotocin: induced diabetic rat tissues

Ranganathan Babujanarthanam1, P. Kavitha1, U.S. Mahadeva Rao2, M. Rajasekara Pandian3
1Department of Biochemistry, K.M.G. College of Arts and Science, Vellore, India
2Department of Biochemistry, SRM College of Arts and Science, Chennai, India
3Department of Zoology, Arignar Anna Government Arts College, Namakkal, India

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Boyle JP, Honeycutt AA, Narayan KM (2001) Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the US. Diabetes Care 24:1936–1940

Craig WJ (1999) Health-promoting properties of common herbs. Am J Clin Nutr 70:491–499

Szkudelski T (2001) The mechanism of alloxan and streptozotocin action in β-cells of the rat pancreas. Physiol Res 50:536–546

Baynes JW (1991) Role of oxidative stress in development of complications of diabetes mellitus. Diabetes 40:405–412

Zhang BB, Moller DE (2000) New approaches in the treatment of type 2 diabetes. Curr Opin Chem Biol 4:461–467

Grover JK, Vats V, Yadav SP (2002) Effect of feeding aqueous extract of Pterocarpus marsupium on glycogen content of tissues and the key enzymes of carbohydrate metabolism. Mol Cell Biochem 241:53–59

Mao CP, Xie ML, Gu ZL (2002) Effects of konjac extract on insulin sensitivity in high fat diet rats. Acta Pharmacol Sin 23:855–859

Hertog MG, Hollman PC, Katan MB, Kromhout D (1993) Intake of potentially anticarcinogenic flavonoids and their determinants in adults in The Netherlands. Nutr Cancer 20:21–29

Manach C, Regerat F, Texier O, Agullo G, Demigne C, Remesy C (1996) Bioavailability, metabolism and physiological impact of 4-oxo-flavonoids. Nutr Res 16:517

Hollman PC, de Vries JH, van Leeuwen SD, Mengelers MJ, Katan MB (1995) Absorption of dietary quercetin glycosides and quercetin in healthy ileostomy volunteers. Am J Clin Nutr 62:1276–1282

Hertog MG, Feskens EJ, Hollman PC, Katan MB, Kromhout D (1993) Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet 342:1007–1011

Sa′nchez de Medina F, Vera B, Ga′lvez J, Zarzuelo A (2002) Effect of quercitrin on the early stages of hapten induced colonic inflammation in the rat. Life Sci 70:3097–3108

Taguchi K, Hagiwara Y, Kajiyama K, Suzuki Y (1993) Pharmacological studies of Houttuyniae herba: the anti-inflammatory effect of quercitrin. Yakugaku Zasshi 113:327–333

Ga′lvez J, Crespo ME, Jime’nez J, Sua’rez A, Zarzuelo A (1993) Antidiarrhoeic activity of quercitrin in mice and rats. J Pharm Pharmacol 45:157–159

Gadotti VM, Schmeling LO, Machado C (2005) Antinociceptive action of the extract and the flavonoid quercitrin isolated from Bauhinia microstachya leaves. J Pharm Pharmacol 57:1345–1351

Muzitano MF, Cruz EA, de Almeida AP (2006) Quercitrin: an antileishmanial flavonoid glycoside from Kalanchoe pinnata. Planta Med 72:81–83

Hollman PC, Katan MB (1999) Dietary flavonoids: intake, health effects and bioavailability. Food Chem Toxicol 37:937–942

Fraga CG, Leibovitz BE, Toppel AL (1988) Lipid peroxidation measured as TBARS in tissue slices. Characterisation and comparison with homogenate and microsome. Free Radic Biol Med 4:155–161

Jiang ZY, Hunt JV, Wolff SP (1992) Ferrous ion oxidation in the presence of xylenol orange for detection of lipid hydroperoxide in low density lipoprotein. Ann Biochem 202:384–387

Ellman GL (1959) Tissue sulfhydryl groups. Arch Biochem Biophys 82:70–77

Omaye ST, Turnbull JD, Sauberlich HE (1979) Selected methods for the determination of ascorbic acid in animal cells, tissues, and fluids. Methods Enzymol 62:3–11

Baker H, Frank O, Angelis B, Feingold S (1951) Plasma tocopherol in man at various times after ingesting free or acetylated tocopherol. Nutr Rep Int 21:531–536

Kakkar P, Das B, Viswanathan PN (1984) Amodified spectrophotometric assay of SOD. Indian J Biochem Biophys 21:130–132

Sinha KA (1972) Colorimetric assay of catalase. Ann Biochem 47:389–394

Rotruck JT, Pope AL, Ganther HE, Swanson AB (1984) Selenium: biochemical roles as a component of glutathione peroxidase. Science 179:588–590

Horn HD, Burns FH (1978) Assay of glutathione reductase activity. In: HV Bergmeyer (ed) Methods of enzymatic analysis. Academic Press, New York, p 142

Nuraliev IuN, Avezov GA (1992) The efficacy of quercetin in alloxan diabetes. Eksp Klin Farmakol 55(1):42–44

Kobori M, Masumoto S, Akimoto Y, Takahashi Y (2009) Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin-induced disturbance of hepatic gene expression in mice. Mol Nutr Food Res 53(7):859–868

Babujanarthanam R, Kavitha P, Sarika S, Rajasekarapandian M (2010) Quercitrin, a bioflavonoid increases glucose utilization and altering the carbohydrate metobolic enzymes in streptozotocin-induced diabetic rat tissues. J Theor Exp Biol 6(3 and 4):225–234

Babujanarthanam R, Kavitha P, Rajasekara Pandian M (2010) Quercitrin, a bioflavonoid improves glucose homeostasis in streptozotocin-induced diabetic tissues by altering glycolytic and gluconeogenic enzymes. Fundam Clin Pharmacol 24:357–364

Korkina LG, Afanas’ev IB (1997) Antioxidant and chelating properties of flavonoids. Adv Pharmacol 38:151–163

Ferrali M, Signofrini C, Caciotti B, Sugherini L, Ciccoli D, Giachetti D, Comporti M (1997) Protection against oxidative damage of erythrocyte membranes by the flavonoid quercetin and its relation to iron chelating activity. FEBS Letters 416:123–139

Elliott AJ, Scheiber SA, Thomas C, Pardini RS (1992) Inhibition of glutathione reductase by flavonoids. Biochem Pharmacol 44:1603–1608

Kozlov AV, Ostrachovitch EA, Afanas’ev IB (1994) Mechanism of inhibitory effects of chelating drugs on lipid peroxidation in rat brain homogenates. Biochem Pharmacol 47:795–799

Aliciguzel Y, Ozen I, Aslan M, Karayalcin U (2003) Activities of xanthine oxidoreductase and antioxidant enzymes in different tissues of diabetic rats. J Lab Clin Med 142:172–177

Maritim AC, Sanders RA, Watkins JB III (2003) Effects of α-lipoic acid on biomarkers of oxidative stress in streptozotocin-induced diabetic rats. J Nutr Biochem 14:288–294

Santini SA, Marra G, Giardina B (1997) Defective antioxidant defenses and enhanced susceptibility to lipid peroxidation in uncomplicated IDDM. Diabetes 46:1853–1858

Kamalakkannan N, Stanely Mainzen Prince P (2004) Antidiabetic and antioxidant activity of Aegle marmelos extract in streptozotocin induced diabetic rats. Pharm Biol 42:125–130

Yadav P, Sarkar S, Bhatnagar D (1997) Action of Capparis deciduas against alloxan-induced oxidative stress and diabetes in rat tissues. Pharmacol Res 36:221–228

Gumieniczek A (2005) Effects of repaglinide on oxidative stress in tissues of diabetic rabbits. Diab Res Clin Pract 68:89–95

Sen CK (1997) Nutritional biochemistry of cellular glutathione. J Nutr Biochem 8:660–672

Dominguez C, Ruiz E, Gussinye M, Carrascosa A (1998) Oxidative stress at onset and in early stages of type I diabetes in children and adolescents. Diab Care 21:1736–1742

Fang YZ, Yang S, Wu G (2002) Free radicals, antioxidants and nutrition. Nutrition 18:872–879

Evelson P, Susemihl C, Villarreal I, Llesuy S, Rodriguez R, Peredo H, Lemberg A, Perazzo J, Filinger E (2005) Hepatic morphological changes and oxidative stress in chronic streptozotocin-diabetic rats. Ann Hepatol 4:115–120