Quercetin reduces chromosome aberrations induced by atrazine in the Allium cepa test

Environmental and Molecular Mutagenesis - Tập 47 Số 4 - Trang 254-259 - 2006
Sabina Mastrangelo1, Massimiliano Tomassetti2, Maria Rosaria Carratù1, Maria Grazia Evandri2, P. Bolle2
1Department of Pharmacology and Human Physiology, University of Bari, Italy
2Department of Human Physiology and Pharmacology, University La Sapienza, Rome, Italy

Tóm tắt

AbstractQuercetin is a widely distributed plant flavonoid possessing a variety of chemical and biological activities, including chelation, free‐radical scavenging, and antioxidant activity. Atrazine is a selective triazine herbicide that has been the subject of an international revision program for human and ecological health risks because of its persistence in the environment. In a previous study, we demonstrated that atrazine was clastogenic in the Allium cepa test. In this present study, we investigated whether quercetin affords protection from the chromosome breaks induced by atrazine. In a preliminary assay, 0.1–20 μg/ml quercetin produced no toxicity or clastogenic activity in the Allium cepa test. Subsequently, we evaluated the effects of 0.5 and 5 μg/ml quercetin on the clastogenicity of 2.5, 5.0, and 7.5 μg/l atrazine. Quercetin (0.5 μg/ml) significantly reduced the frequency of total aberrations induced by 7.5 μg/l atrazine, while both concentrations of quercetin significantly decreased the frequency of fragments induced by 7.5 μg/l atrazine. The results of this study indicate that plant flavonoids such as quercetin may protect against the genotoxic effects of atrazine. Efforts to understand the extent to which plant flavonoids influence the biological activities of genotoxicants and the mechanisms involved in the interactions could help to better discern the advantages and disadvantages of their use and to clarify their possible protective role against pollutants. Environ. Mol. Mutagen., 2006 © 2006 Wiley‐Liss, Inc.

Từ khóa


Tài liệu tham khảo

10.1093/toxsci/kfh152

10.1007/978-1-4613-0399-2_8

10.1016/0031-6989(85)90041-4

10.1002/jat.1049

10.1002/em.20007

10.1016/0165-1161(83)90240-6

10.1002/(SICI)1098-2280(1997)29:3<277::AID-EM8>3.0.CO;2-9

10.1897/1551-5028(2001)020<0084:TOPTAM>2.0.CO;2

10.1136/oem.60.9.e11

10.1111/j.1601-5223.1985.tb00471.x

10.1016/0278-6915(95)00077-1

10.1016/j.mrgentox.2004.02.008

International Agency for Research on Cancer (IARC).1983.Monographs on the evaluation of the carcinogenic risk of chemicals to humans.31:213–229.

10.1016/S0921-8777(99)00074-9

Kidd H, 1991, The Agrochemicals Handbook

10.1093/mutage/17.1.45

10.1002/(SICI)1098-2280(1998)32:1<39::AID-EM5>3.0.CO;2-6

10.1016/0165-1218(81)90043-4

Middleton E, 2000, The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer, Pharmacol Rev, 52, 673

10.1016/S0891-5849(01)00812-7

10.1021/jf0490798

10.1016/0165-1218(95)90037-3

10.1146/annurev.nutr.22.111401.144957

10.1093/toxsci/54.1.121

10.1080/07352689009382280

10.1016/j.ejphar.2004.09.012

10.1042/BJ20021972

10.1289/ehp.98106197

10.1021/es0403662

10.1016/S0304-3835(03)00412-9

10.1002/mnfr.200500036

10.1093/jn/135.3.525

10.1111/j.1440-1681.2004.04072.x

10.1146/annurev.nutr.21.1.381

10.1093/oxfordjournals.aje.a008905

Thông tin
Thông tin xuất bản

Environmental and Molecular Mutagenesis

Tập 47 Số 4

254-259

Thông tin tác giả