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Quercetin cải thiện rối loạn nhịp sinh học gan ở chuột tuổi trung niên được cho ăn chế độ ăn thiếu vitamin D
Tóm tắt
Mục tiêu của chúng tôi là xác định xem quercetin có khả năng cải thiện rối loạn nhịp sinh học và chuyển hóa dưới điều kiện thiếu vitamin D hay không. Chuột trung niên được chia ngẫu nhiên thành bốn nhóm, gồm nhóm chứng (CON), nhóm chế độ ăn thiếu vitamin D (VDD), nhóm quercetin (Q), và nhóm can thiệp quercetin trong chế độ ăn thiếu vitamin D (VDQ), với tổng thời gian can thiệp là 12 tuần. Chuột được hiến xác ở thời điểm zeitgeber time1 (ZT1) và ZT13. Tại ZT1, sự biểu hiện protein CLOCK từ các nhóm VDD, Q, và VDQ; CRY1 từ nhóm Q; và CRY2 từ nhóm VDD đều thấp hơn đáng kể so với nhóm CON. Sự biểu hiện mRNA của Sirt1, Bmal1, Clock, Cry1, và Cry2 trong các nhóm VDQ, cũng như Bmal1, Clock, và Cry1 từ nhóm Q, đã giảm đáng kể so với nhóm CON. Tại ZT13, so với nhóm CON, insulin nhịn đói và chỉ số đánh giá mô hình cân bằng-insulin kháng (HOMA-IR) cao hơn trong nhóm VDD; BMAL1 tăng đáng kể, trong khi protein CLOCK và CRY1 giảm đáng kể trong nhóm VDD; protein CLOCK từ nhóm VDQ cao một cách đáng kể so với các nhóm CON, VDD, và Q, hơn nữa, sự biểu hiện protein BMAL1 từ nhóm VDQ cũng tăng so với nhóm CON. Sự biểu hiện mRNA của Bmal1, Clock, Per2, Cry1, và Cry2 trong các nhóm VDQ tăng đáng kể so với nhóm CON. Sự biểu hiện mRNA của Bmal1 từ nhóm VDQ giảm so với cả nhóm VDD và Q. Kết luận, chế độ ăn thiếu vitamin D dẫn đến rối loạn nhịp sinh học gan, và quercetin cải thiện sự mất đồng bộ nhịp sinh học gan. Việc bổ sung quercetin có thể có hiệu quả trong việc cân bằng nhịp sinh học trong điều kiện thiếu vitamin D.
Từ khóa
#quercetin #rối loạn nhịp sinh học #vitamin D #chuột trung niên #chuyển hóaTài liệu tham khảo
Berretta M, Quagliariello V, Bignucolo A, Facchini S, Maurea N, Di Francia R, Fiorica F, Sharifi S, Bressan S, Richter SN, Camozzi V, Rinaldi L, Scaroni C, Montopoli M (2022) The multiple effects of vitamin D against chronic diseases: from reduction of lipid peroxidation to updated evidence from clinical studies. Antioxidants (Basel) 11. https://doi.org/10.3390/antiox11061090
Lontchi-Yimagou E, Kang S, Goyal A, Zhang K, You JY, Carey M, Jain S, Bhansali S, Kehlenbrink S, Guo P, Rosen ED, Kishore P, Hawkins M (2020) Insulin-sensitizing effects of vitamin D repletion mediated by adipocyte vitamin D receptor: studies in humans and mice. Mol Metab 42:101095. https://doi.org/10.1016/j.molmet.2020.101095
Barchetta I, Cimini FA, Chiappetta C, Bertoccini L, Ceccarelli V, Capoccia D, Gaggini M, Di Cristofano C, Della Rocca C, Silecchia G, Leonetti F, Lenzi A, Gastaldelli A, Cavallo MG (2020) Relationship between hepatic and systemic angiopoietin-like 3, hepatic vitamin D receptor expression and NAFLD in obesity. Liver Int 40:2139–2147. https://doi.org/10.1111/liv.14554
Cimini FA, Barchetta I, Carotti S, Bertoccini L, Baroni MG, Vespasiani-Gentilucci U, Cavallo MG, Morini S (2017) Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease. World J Gastroenterol 23:3407–3417. https://doi.org/10.3748/wjg.v23.i19.3407
Borges-Canha M, Neves JS, Mendonca F, Silva MM, Costa C, Cabral PM, Guerreiro V, Lourenco R, Meira P, Salazar D, Ferreira MJ, Pedro J, Leite AR, Von-Hafe M, Vale C, Viana S, Sande A, Belo S, Lau E et al (2021) The impact of vitamin d in non-alcoholic fatty liver disease: a cross-sectional study in patients with morbid obesity. Diabetes Metab Syndr Obes 14:487–495. https://doi.org/10.2147/DMSO.S286334
Heo NJ, Park HE, Yoon JW, Kwak MS, Yang JI, Chung SJ, Yim JY, Chung GE (2021) The association between vitamin D and nonalcoholic fatty liver disease assessed by controlled attenuation parameter. J Clin Med 10. https://doi.org/10.3390/jcm10122611
Voigt RM, Forsyth CB, Green SJ, Engen PA, Keshavarzian A (2016) Chapter nine - circadian rhythm and the gut microbiome. In: Cryan JF, Clarke G (eds) International Review of Neurobiology. Academic Press, pp 193–205
Cox KH, Takahashi JS (2019) Circadian clock genes and the transcriptional architecture of the clock mechanism. J molecular endocrinol 63:R93–R102. https://doi.org/10.1530/JME-19-0153
Asher G, Gatfield D, Stratmann M, Reinke H, Dibner C, Kreppel F, Mostoslavsky R, Alt FW, Schibler U (2008) SIRT1 regulates circadian clock gene expression through PER2 deacetylation. Cell 134:317–328. https://doi.org/10.1016/j.cell.2008.06.050
Noh SG, Jung HJ, Kim S, Arulkumar R, Kim DH, Park D, Chung HY (2022) Regulation of circadian genes Nr1d1 and Nr1d2 in sex-different manners during liver aging. Int J Mol Sci 23. https://doi.org/10.3390/ijms231710032
Reinke H, Asher G (2016) Circadian clock control of liver metabolic functions. Gastroenterol 150:574–580. https://doi.org/10.1053/j.gastro.2015.11.043
Grosbellet E, Zahn S, Arrive M, Dumont S, Gourmelen S, Pevet P, Challet E, Criscuolo F (2015) Circadian desynchronization triggers premature cellular aging in a diurnal rodent. FASEB J 29:4794–4803. https://doi.org/10.1096/fj.14-266817
Solt LA, Wang Y, Banerjee S, Hughes T, Kojetin DJ, Lundasen T, Shin Y, Liu J, Cameron MD, Noel R, Yoo SH, Takahashi JS, Butler AA, Kamenecka TM, Burris TP (2012) Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists. Nature 485:62–68. https://doi.org/10.1038/nature11030
Mlcek J, Jurikova T, Skrovankova S, Sochor J (2016) Quercetin and its anti-allergic immune response. Molecules (Basel Switzerland) 21:623. https://doi.org/10.3390/molecules21050623
Michala AS, Pritsa A (2022) Quercetin: a molecule of great biochemical and clinical value and its beneficial effect on diabetes and cancer. Diseases 10. https://doi.org/10.3390/diseases10030037
Li Y, Yao J, Han C, Yang J, Chaudhry MT, Wang S, Liu H, Yin Y (2016) Quercetin, inflammation and immunity. Nutrients
Lee K-Y, Choi H-S, Choi H-S, Chung KY, Lee B-J, Maeng H-J, Seo M-D (2016) Quercetin directly interacts with vitamin D receptor (VDR): structural implication of VDR activation by quercetin. Biomol Ther (Seoul)
Kanhere M, Chassaing B, Gewirtz AT, Tangpricha V (2018) Role of vitamin D on gut microbiota in cystic fibrosis. J Steroid Biochem Mol Biol
Porras D, Nistal E, Martínez-Flórez S, Pisonero-Vaquero S, Olcoz JL, Jover R, González-Gallego J, García-Mediavilla MV, Sánchez-Campos S (2017) Protective effect of quercetin on high-fat diet-induced non-alcoholic fatty liver disease in mice is mediated by modulating intestinal microbiota imbalance and related gut-liver axis activation. Free Radic Biol Med
Lv M, Yang S, Cai L, Qin L-Q, Li B-Y, Wan Z (2018) Effects of quercetin intervention on cognition function in APP/PS1 mice was affected by vitamin D status. Mol Nutr Food Res
Shiue I (2013) Low vitamin D levels in adults with longer time to fall asleep: US NHANES, 2005-2006. Int J Cardiol 168:5074–5075. https://doi.org/10.1016/j.ijcard.2013.07.195
Subramanian P, Kaliyamoorthy K, Jayapalan JJ, Abdul-Rahman PS, Haji Hashim O (2017) Influence of quercetin in the temporal regulation of redox homeostasis in Drosophila melanogaster. J Insect Sci 17. https://doi.org/10.1093/jisesa/iex040
Okada Y, Okada M (2020) Quercetin, caffeic acid and resveratrol regulate circadian clock genes and aging-related genes in young and old human lung fibroblast cells. Mol Biol Rep 47:1021–1032. https://doi.org/10.1007/s11033-019-05194-8
Sadria M, Layton AT (2021) Aging affects circadian clock and metabolism and modulates timing of medication. iScience 24:102245. https://doi.org/10.1016/j.isci.2021.102245
Yang S, Zhou H, Wang G, Zhong XH, Shen QL, Zhang XJ, Li RY, Chen LH, Zhang YH, Wan Z (2020) Quercetin is protective against short-term dietary advanced glycation end products intake induced cognitive dysfunction in aged ICR mice. J Food Biochem 44:e13164. https://doi.org/10.1111/jfbc.13164
Yang S, Wang G, Ma ZF, Qin LQ, Zhai YJ, Yu ZL, Xue M, Zhang YH, Wan Z (2020) Dietary advanced glycation end products-induced cognitive impairment in aged ICR mice: protective role of quercetin. Mol Nutr Food Res 64:e1901019. https://doi.org/10.1002/mnfr.201901019
Akyel YK, Ozturk Civelek D, Ozturk Seyhan N, Gul S, Gazioglu I, Pala Kara Z, Levi F, Kavakli IH, Okyar A (2023) Diurnal changes in capecitabine clock-controlled metabolism enzymes are responsible for its pharmacokinetics in male mice. J Biol Rhythms 38:171–184. https://doi.org/10.1177/07487304221148779
Rodriguez RM, Cortes-Espinar AJ, Soliz-Rueda JR, Feillet-Coudray C, Casas F, Colom-Pellicer M, Aragones G, Avila-Roman J, Muguerza B, Mulero M, Salvado MJ (2022) Time-of-day circadian modulation of grape-seed procyanidin extract (GSPE) in hepatic mitochondrial dynamics in cafeteria-diet-induced obese rats. Nutrients 14. https://doi.org/10.3390/nu14040774
Hossein-nezhad A, Holick MF (2012) Optimize dietary intake of vitamin D: an epigenetic perspective. Curr Opin Clin Nutr Metab Care 15:567–579. https://doi.org/10.1097/MCO.0b013e3283594978
Burnett CML, Grobe JL (2013) Direct calorimetry identifies deficiencies in respirometry for the determination of resting metabolic rate in C57Bl/6 and FVB mice. American journal of physiology. Endocrinol metab 305:E916–E924. https://doi.org/10.1152/ajpendo.00387.2013
Godala M, Sewerynek E, Maslach D, Krzyzak M, Gaszynska E (2022) Resting metabolic rate in women with endocrine and osteoporotic disorders in relation to nutritional status, diet and 25(OH)D concentration. Int J Environ Res Public Health 19. https://doi.org/10.3390/ijerph19053118
Nikooyeh B, Shariatzadeh N, Rismanchi M, Hollis BW, Neyestani TR (2021) Daily intake of yogurt drink fortified either with vitamin D alone or in combination with added calcium causes a thyroid-independent increase of resting metabolic rate in adults with type 2 diabetes: a randomized, double-blind, clinical trial. Appl Physiol Nutr Metab 46:1363–1369. https://doi.org/10.1139/apnm-2021-0248
Mu Y, Cheng D, Yin TL, Yang J (2021) Vitamin D and polycystic ovary syndrome: a narrative review. Reprod Sci 28:2110–2117. https://doi.org/10.1007/s43032-020-00369-2
Saleem N, Rizvi NB, Elahi S (2021) Prevalence of vitamin D deficiency and its association with insulin resistance in obese women with normal fasting glucose. BioMed res int 2021:2259711–2259711. https://doi.org/10.1155/2021/2259711
Spoto B, Pisano A, Zoccali C (2016) Insulin resistance in chronic kidney disease: a systematic review. Am J Physiol-Renal Physiol 311:F1087–F1108. https://doi.org/10.1152/ajprenal.00340.2016
Akhtar A, Sah SP (2020) Insulin signaling pathway and related molecules: role in neurodegeneration and Alzheimer’s disease. Neurochem Int 135:104707. https://doi.org/10.1016/j.neuint.2020.104707
Jarrett RJ, Keen H (1969) Diurnal variation of oral glucose tolerance: a possible pointer to the evolution of diabetes mellitus. Br Med J 2:341–344. https://doi.org/10.1136/bmj.2.5653.341
He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z (2016) The small molecule nobiletin targets the molecular oscillator to enhance circadian rhythms and protect against metabolic syndrome. Cell Metab 23:610–621. https://doi.org/10.1016/j.cmet.2016.03.007
Arble DM, Bass J, Laposky AD, Vitaterna MH, Turek FW (2009) Circadian timing of food intake contributes to weight gain. Obesity (Silver Spring) 17:2100–2102. https://doi.org/10.1038/oby.2009.264
Scheer FA, Hilton MF, Mantzoros CS, Shea SA (2009) Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A 106:4453–4458. https://doi.org/10.1073/pnas.0808180106
Stenvers DJ, Scheer F, Schrauwen P, la Fleur SE, Kalsbeek A (2019) Circadian clocks and insulin resistance. Nat Rev Endocrinol 15:75–89. https://doi.org/10.1038/s41574-018-0122-1
Romano F, Muscogiuri G, Di Benedetto E, Zhukouskaya VV, Barrea L, Savastano S, Colao A, Di Somma C (2020) Vitamin D and sleep regulation: is there a role for vitamin D? Curr Pharm Des
Zou R, Wang S, Cai H, Li F, Lin P, Wang Y, Wang C (2021) Vitamin D deficiency in children with vasovagal syncope is associated with impaired circadian rhythm of blood pressure. Front neurosci 15:712462–712462. https://doi.org/10.3389/fnins.2021.712462
Liu Y, Beyer A, Aebersold R (2016) On the dependency of cellular protein levels on mRNA abundance. Cell 165:535–550. https://doi.org/10.1016/j.cell.2016.03.014
Xu T, Lu B (2019) The effects of phytochemicals on circadian rhythm and related diseases. Crit Rev Food Sci Nutr 59:882–892. https://doi.org/10.1080/10408398.2018.1493678