Quercetin and naringenin; effects on ulcer formation and gastric secretion in rats

Phytotherapy Research - Tập 7 Số 2 - Trang 150-153 - 1993
María J. Martín1, Virginia Motilva1, C. Alarc ÓN de la Lastra1
1Departemento de Farmacia y Tecnologí Farmaceutica, Laboratorio de Farmacodinamia, Facultad de Farmacia, Universidad de Sevilla, C. Professor Garcia Gonzalez s/n, 41012 Seville, Spain

Tóm tắt

Abstract

The antiulcerogenic effect of two flavonoids, quercetin and naringenin, in acute gastric ulcer (cold‐restraint and pylorus‐ligated) has been investigated. In both models quercetin and naringenin presented a significant decrease in ulcer index with respect to the control group. Nevertheless, in the Shay‐ligated method no decrease in either volume, acidity or pepsin were observed, however, a significant difference was found in histamine secretion values.

Từ khóa


Tài liệu tham khảo

10.1016/0006-2952(89)90410-3

10.1111/j.2042-7158.1992.tb03239.x

10.1002/ptr.2650020208

Boughton‐Smith N. K., 1989, Environment of leukotrienes in acid gastric damage, Meth. Find. Exp. Clin. Pharmacol., 11, 53

10.1111/j.2042-7158.1991.tb03521.x

10.1016/0014-4800(67)90006-8

Deby C., 1984, Cerebral Ischemia, 249

Gabor M., 1986, The Pharmacology of Benzopyrene Derivatives and Related Compounds, 513

Guth P. H., 1966, Microcirculatory and mast cell change in restraint‐induced gastric ulcer, Gastroenterology, 50, 562, 10.1016/S0016-5085(66)80034-3

10.1248/cpb.33.1327

10.1016/0014-2999(86)90026-9

10.1016/0006-2952(84)90423-4

10.1515/bchm2.1972.353.1.911

10.1016/S0021-9258(19)52451-6

10.1111/j.2042-7158.1988.tb05173.x

Parmar N. S., 1983, The gastric anti‐ulcer activity of naringenin, a specific histidine decarboxylase inhibitor, Int. J. Tiss. Res., 4, 415

10.1016/0014-2999(81)90598-7

Pincemail J., 1985, Flavonoids and Bioflavonoids, 423

10.1016/0014-2999(71)90086-0

10.1002/ptr.2650020307

10.1016/0006-2952(88)90499-6

10.1111/j.2042-7158.1991.tb03519.x

10.1111/j.2042-7158.1988.tb06317.x

10.1111/j.2042-7158.1990.tb05354.x

10.3181/00379727-124-31970

Shay J. P., 1954, A simple method for the uniform production of gastric ulceration in the rat, Gastroenterology, 5, 43

Swies J., 1984, Antiaggregatory effect of flavonoids in vivo and their influence on lipoxygenase and cyclooxygenase in vitro, Pol. J. Pharmacol. Pharm., 36, 455

Szabo S., 1989, Critical and timely review of the concept of gastric cytoprotection, Acta Physiol. Hung, 73, 115

Thông tin
Thông tin xuất bản

Phytotherapy Research

Tập 7 Số 2

150-153

Thông tin tác giả