Quantification of myocardial blood flow and extracellular volumes using a bolus injection of Gd‐DTPA: Kinetic modeling in canine ischemic disease

Magnetic Resonance in Medicine - Tập 23 Số 2 - Trang 239-253 - 1992
Leo D. Diesbourg1, Frank S. Prato2, Gerald Wisenberg3, Dick Drost2, Tara P. Marshall3, S E Carroll4, Blair J. O’Neill3
1Lawson Research Institute, St. Joseph's Health Centre of London, Ontario, Canada.
2Lawson Research Institute and Department of Nuclear Medicine, St. Joseph's Health Centre of London and University of Western Ontario, London, Ontario, Canada N6A 4V2
3Lawson Research Institute and Department of Medicine, St. Joseph's Health Centre of London and University of Western Ontario, London, Ontario, Canada N6A 4V2
4Lawson Research Institute and Department of Surgery, St. Joseph's Health Centre of London and University of Western Ontario, London, Ontario, Canada N6A 4V2

Tóm tắt

AbstractIn order to clarify the relationship between coronary artery disease (including myocardial infarction) and image contrast in gadolinium diethylenetriaminepentaacetic acid (Gd‐DTPA‐enhanced MRI it was decided to model the myocardial tissue distribution and clearance of Gd‐DTPA using the modified Kety equation. Using a canine model, myocardial tissue Gd‐DTPA concentrations ([Gd‐DTPA]m) were measured 1 or 5 min after a bolus injection of Gd‐DTPA or immediately after the end of a constant infusion of Gd‐DTPA in a total of 35 dogs. It was found that within 5 min of a bolus injection [Gd‐DTPA]m is determined primarily by myocardial blood flow (MBF) and after about 10 min primarily by myocardial extracellular volumes (MECV). This study suggests that repeat, rapid (every 2–4 s) measurements of myocardial T1 relaxation rates following the bolus injection of Gd‐DTPA are required to calculate MBF (i.e., myocardial tissue perfusion) and MECV. © 1992 Academic Press, Inc.

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Tài liệu tham khảo

10.1148/radiology.160.2.3726135

10.2214/ajr.150.3.531

P.Liu A.Villringer A.Vincent R.Lauffer D. L.Johnston R.Buxton andT. J.Brady in “Proceedings of the 5th Annual Meeting of the Society of Magnetic Resonance in Medicine Montreal Canada 1986 ” p.22.

10.1161/01.CIR.74.6.1434

10.1148/radiology.153.1.6473778

10.1148/radiology.158.3.3945751

Johnston D. L., 1987, J. Nucl. Med., 28, 871

Rosen B. R., 1989, Magn. Reson. Q., 5, 263

Kety S. S., 1951, Pharmacol. Rev., 3, 1

Lee T. Y., 1988, Phys. Med. Biol., 33

10.1378/chest.73.6.843

10.2214/ajr.142.3.619

Prato F. S., 1988, J. Nucl. Med., 29, 1683

O'Neil P. V., 1986, Advanced Engineering Mathematics, 43

Press W. H., 1986, Numerical Recipes, 113

10.1111/j.1748-1716.1980.tb06549.x

Gould K. L., 1978, Am. J. Cardiol., 41, 219

Dole W. P., 1982, Am. J. Physiol., 243, H371

10.1016/0730-725X(86)90025-1

10.1002/mrm.1910030109

T.Keys K.Wilkins F. S.Prato andD. J.Drost “Proceedings of the 5th Annual Meeting of the Society of Magnetic Resonance in Medicine Montreal Canada 1986.”

Bevington P. R., 1969, Data Reduction and Error Analysis for the Physical Sciences, 105

Snedecor G. W., 1980, Statistical Methods, 365

10.2214/ajr.146.5.907

Johnston D. L., 1988, Can. J. Cardiol., 4, 116

Ganong W. F., 1973, Review of Medical Physiology, 5

10.1002/mrm.1910080402

10.1002/mrm.1910030514

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Magnetic Resonance in Medicine

Tập 23 Số 2

239-253

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