Pyrimidine Starvation Induced by Adenosine in Fibroblasts and Lymphoid Cells: Role of Adenosine Deaminase

American Association for the Advancement of Science (AAAS) - Tập 182 Số 4114 - Trang 836-837 - 1973
Howard Green1, Teh‐Sheng Chan1
1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.

Tóm tắt

In the presence of 10 -4 to 10 -5 molar adenosine, established cell lines of fibroblastic or lymphoid origin die of pyrimidine starvation. Less than lethal concentrations inhibit cell growth. Over a broad concentration range, the effects of adenosine are prevented by providing a suitable pyrimidine source. We suggest that the recently described immune deficiency disease associated with absence of adenosine deaminase may be the result of pyrimidine starvation induced by adenosine nucleotides in cells of the lymphoid system.

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Tài liệu tham khảo

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American Association for the Advancement of Science (AAAS)

Tập 182 Số 4114

836-837

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