Pyrazines and their N-oxides

Chemistry of Heterocyclic Compounds - Tập 4 - Trang 533-535 - 1971
A. S. Elina1, I. S. Musatova1, G. P. Syrova1
1Ordzhonikidze All-Union Chemical and Pharmaceutical Scientific-Research Institute, Moscow

Tóm tắt

Two isomeric mono-N-oxides of 2-aminopyrazine and the 1,4-di-N-oxide have been synthesized. A marked fall in the capacity of these compounds for nucleophilic exchange reactions and for rearrangements in acid and alkaline media has been found, which distinguishes them from the corresponding N-oxides of 2-aminoquinoxaline.

Tài liệu tham khảo

A. S. Elina and L. G. Tsyrul'nikova, ZhOKh, 33, 1544, 1963. W. H. Gumprecht, T. E. Beukelman, and R. Paju, J. Org. Chem. 29, 2477, 1964. Kazuo Tou, Masaru Ogata, and Hudeo Kano, Chem. and Pharm. Bull. 11, 235, 1963. Masaru Ogata, Haruyuki Watanabe, Kazuo Tori, and Hideo Kano, Tetrah. Lett., 19, 1964. A. S. Elina and I. S. Musatova, KhGS, collection 1, p. 419, 1967.