Pulmonary gas exchange capacity is reduced during normovolaemic haemodilution in healthy human subjects

Canadian Journal of Anaesthesia - Tập 43 - Trang 672-677 - 1996
Charles Le Merre1, Michel Dauzat2, Patrice Poupard3, Rémi Targhetta1, Christine Fabre1, Stéphane Bouges4, Jean-Jacques Eledjam3, Pierre Balmès1
1Pneumology - Internal Medicine A, University Hospital, Nimes, France
2Vascular Laboratory, University Hospital, Nîmes, France
3Department of Anaesthesia and Intensive Care, University Hospital, Nîmes, France
4Department of Biostatistics, University Hospital, Nîmes, France

Tóm tắt

To test the hypothesis that a physiological compensatory mechanism maintains respiratory gas exchange during normovolaemic haemodilution. Pulmonary gas exchange capacity was evaluated in seven healthy subjects by measuring the lung diffusion of carbon monoxide (DLCO). During the measurement, various breath-holding times, inspiratory volumes, and sitting or supine positions, were randomly selected in an attempt to alter pulmonary capillary perfusion. KCO was calculated as the percentage of theoretical values of the ratio of DLCO by alveolar volume and normalized by sex, age, and height. Normovolaemic haemodilution (NH) was performed by bleeding an average blood volume of 1 L with simultaneous Dextran 60 replacement to obtain an haematocrit below 35%. After NH, haemoblogin concentration [Hb] decreased from 14.94 ± 0.96 to 12.5 ± 0.98 g · dl−1 (P < 0.001). KCO decreased (P < 0.02) but remained closely correlated to [Hb] at every lung volume (< 0.02). Breathholding time and body position had no effect. Moderate NH impairs pulmonary gas exchange capacity in awake, resting healthy subjects. There is no evidence of any compensatory mechanism since the KCO vs [Hb] relationship is unchanged.

Tài liệu tham khảo

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Thông tin xuất bản

Canadian Journal of Anaesthesia

Tập 43

672-677

Thông tin tác giả