Public Health Impacts of Foodborne Mycotoxins

Annual review of food science and technology - Tập 5 Số 1 - Trang 351-372 - 2014
Felicia Wu1, John D. Groopman2, James J. Pestka1
1Department of Food Science and Human Nutrition, Michigan State University, East Lansing, Michigan, 48824
2Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205;

Tóm tắt

Mycotoxins are toxic and carcinogenic metabolites produced by fungi that colonize food crops. The most agriculturally important mycotoxins known today are aflatoxins, which cause liver cancer and have also been implicated in child growth impairment and acute toxicoses; fumonisins, which have been associated with esophageal cancer (EC) and neural tube defects (NTDs); deoxynivalenol (DON) and other trichothecenes, which are immunotoxic and cause gastroenteritis; and ochratoxin A (OTA), which has been associated with renal diseases. This review describes the adverse human health impacts associated with these major groups of mycotoxins. First, we provide background on the fungi that produce these different mycotoxins and on the food crops commonly infected. Then, we describe each group of mycotoxins in greater detail, as well as the adverse effects associated with each mycotoxin and the populations worldwide at risk. We conclude with a brief discussion on estimations of global burden of disease caused by dietary mycotoxin exposure.

Từ khóa


Tài liệu tham khảo

10.1179/027249304225013420

10.1126/science.8191284

10.3109/03009749409117126

10.1021/ja00894a050

10.1093/carcin/4.9.1193

Autrup H, 1987, Cancer Res., 47, 3430

10.1289/ehp.8384

Beardall JM, Miller JD. 1994. Diseases in humans with mycotoxins as possible causes. See Miller & Trenholm 1994, pp. 487–569

Bergsjo B, 1993, VetResCommun, 17, 283

10.1111/j.1439-0442.1992.tb00240.x

10.1016/S0140-6736(89)91684-X

Bhat RV, 1977, Indian J. Med. Res., 66, 55

Blount WP, 1961, J. Br. Turkey Fed., 9, 52

10.1080/109374000281113

10.1038/350429a0

Bui-Klimke T, Wu F. 2014. Ochratoxin A and human health risk: a review of the evidence. Crit. Rev. Food Sci. Nutr. In press

10.1093/ije/11.2.112

10.1038/227403a0

Canady RA, 2001, Safety Evaluation of Certain Mycotoxins in Food, 56, 420

CDC, 2004, MMWR Morb. Mortal. Wkly. Rep., 53, 790

10.1158/1940-6207.CAPR-13-0168

10.1002/ijc.21952

10.1016/j.fct.2005.09.004

10.1002/jor.22073

10.1038/ki.1994.220

10.1093/toxsci/kfr110

Eriksen GS, 1998, Fusarium Toxins in Cereals—A Risk Assessment

10.1002/ijc.25516

10.1016/0278-6915(87)90302-4

10.1093/carcin/9.7.1323

10.1093/carcin/12.7.1247

10.1002/bdra.20148

10.1080/02652030110070030

10.1289/ehp.6954

10.1136/bmj.325.7354.20

10.1051/vetres:2007022

Greenblatt MS, 1994, Cancer Res., 54, 4855

10.1073/pnas.0701248104

10.1073/pnas.82.19.6492

Groopman JD, 1992, Cancer Epidemiol. Biomarkers Prev., 1, 221

10.1146/annurev.publhealth.29.020907.090859

Groopman JD, 1992, Cancer Res., 52, 45

10.1007/s00296-011-2335-7

10.1002/jat.2550090204

10.1126/science.286.5449.2453

10.1038/350427a0

10.2527/1999.773693x

IARC, 1972, IARC Monographs on the Evaluation of Carcinogenic Risks to Humans, Vol. 1, Some Inorganic Substances, Chlorinated Hydrocarbons, Aromatic Amines, N-Nitroso Compounds, and Natural Products: Summary of Data Reported and Evaluation

IARC, 1993, IARC monographs on the evaluation of carcinogenic risks to humans, Vol. 56. Some naturally occurring substances: food items and constituents, heterocyclic aromatic amines and mycotoxins

10.1002/tcm.1770150606

Jackson PE, 2001, Cancer Res., 61, 33

10.1093/carcin/bgg101

JECFA, 1998, Safety Evaluation of Certain Food Additives and Contaminants: WHO Food Additive Series

JECFA, 2002, WHO Tech. Rep. Ser., 906, 42

JECFA, 2011, WHO Tech. Rep. Ser., 959, 37

JECFA, 2011, WHO Tech. Rep. Ser., 966, 1

10.1093/intimm/dxh262

Joffe AZ, 1978, Mycotoxic Fungi, Mycotoxins,Mycotoxicoses: An Encylcopedic Handbook, 21

10.1080/10408390500436185

10.1016/j.joca.2013.05.005

10.1080/19440041003677475

10.3109/10408444.2011.575766

10.1093/jnci/92.2.148

10.1016/S0140-6736(75)91829-2

Krogh P, 1974, Acta Pathol. Microbiol. Scand. Suppl., 1994, 1

10.1016/j.fct.2007.08.003

Kuiper-Goodman T, 1994, Mycotoxins in Grain, 439

10.1038/1921095a0

10.1289/ehp.7998

10.1080/02652030110070058

10.1631/jzus.B071322

10.1016/j.ejca.2012.02.009

10.1289/ehp.0901388

10.1159/000335046

Lunn RM, 1997, Cancer Res., 57, 3471

Luo X. 1994. Food poisoning caused byFusariumtoxins In Proceedings of the Second Asian Conference on Food Safety, ed. ILSI, pp. 129–36. Thailand: Text J. Publ. Co., Ltd.

Lye MS, 1995, Am. J. Trop. Med. Hyg., 53, 68

10.1007/s10995-008-0439-9

Marasas WFO, 1988, Fusarium moniliforme. Onderstepoort J. Vet. Res, 55, 197

10.1289/ehp.8221

Miller JD, 1994, Mycotoxins in Grain: Compounds Other than Aflatoxin.

10.1093/jn/134.4.711

10.1590/S0102-09352001000300011

National Toxicology Program (NTP), 1989, Natl. Toxicol. Program Tech. Rep. Ser., 358, 1

10.1080/003655200750023769

10.1038/1951062a0

10.1016/S0140-6736(82)92411-4

10.1016/0278-6915(89)90018-5

Okoth SA, 2004, Afr. J. Health Sci., 11, 43

10.1177/104063879200400112

10.1016/0140-6736(91)92236-U

10.3322/canjclin.55.2.74

Peers FG, 1977, Ann. Nutr. Aliment., 31, 1005

10.3390/toxins2061300

10.3920/WMJ2010.1247

10.1016/0278-6915(87)90264-X

10.1080/10937400590889458

10.1002/mnfr.200600137

10.1007/978-1-4615-0629-4_25

10.1128/AEM.02370-06

Pronk M, Schothorst R, Egmond Hv. 2002. Toxicology and occurrence of nivalenol, fusarenon X, diacetoxyscirpenol, neosolaniol and 3- and 15- acetyldeoxynivalenol; a review of six trichothecenes. RIVM Rep. 388802024, Natl. Inst. Public Health Environ, Bilthoven, Neth.http://www.rivm.nl/en/Documents_and_publications/Scientific/Reports/2002/november/Toxicology_and_occurrence_of_nivalenol_fusarenon_X_diacetoxyscirpenol_neosolaniol_and_3_and_15_acetyldeoxynivalenol_a_review_of_six_trichothecenes?sp=cml2bXE9ZmFsc2U7c2VhcmNoYmFzZT01MTk3MDtyaXZtcT1mYWxzZTs=&pagenr=5198

Qian GS, 1994, Cancer Epidemiol. Biomarkers Prev., 3, 3

10.1038/444029a

10.1016/j.cbi.2005.10.106

10.1016/0140-6736(92)91528-G

10.1002/19960401NT6

10.1016/0272-0590(88)90268-0

10.1016/j.foodcont.2008.02.005

10.1038/1921096a0

SCF. 2002. Opinion of the Scientific Committee on Food on Fusarium toxins. Part 6: Group evaluation of T-2 toxin, HT-2 toxin, nivalenol and deoxynivalenol. SCF Rep. SCF/CS/CNTM/MYC/27, Eur. Comm., Brussels, Belg.http://ec.europa.eu/food/fs/sc/scf/out123_en.pdf

10.1016/0015-6264(71)90080-0

10.1080/02652030601101136

10.1080/02652030210126541

10.1111/j.1365-3156.2009.02435.x

10.1146/annurev.med.47.1.285

10.1016/j.fgb.2007.03.001

10.4315/0362-028X-69.7.1690

10.1289/ehp.9302

10.1007/s002040000157

Sugita-Konishi Y, 2010, Mycotoxins in Food, Feed and Bioweapons, 253

10.1080/02652030601013471

Sun G, 2011, Food Addit. Contam. A Chem. Anal. Control Expo. Risk Assess., 18, 1

10.1007/s12011-012-9469-7

10.1002/hep.510300204

10.1021/jf00018a016

10.1016/1056-8719(94)90062-0

10.1016/j.fct.2007.07.005

10.1021/tx050076e

10.1289/ehp.5753

10.1093/ije/dym122

10.1017/S095442241200008X

10.1038/1951060a0

10.1038/bjc.1985.107

Vatanasapt V, 1995, Cancer Epidemiol. Biomarkers Prev., 4, 475

10.1191/096032798678908369

10.1002/(SICI)1097-0215(19960904)67:5<620::AID-IJC5>3.0.CO;2-W

10.1016/S0300-483X(02)00253-6

Wild CP, 1992, Cancer Epidemiol. Biomarkers Prev., 1, 229

10.1080/19440049.2011.563370

Wogan GN, 1967, Cancer Res., 27, 2370

Wu F . 2013. Aflatoxin exposure and chronic human diseases: estimates of burden of disease. InAflatoxins: Finding Solutions for Improved Food Safety, ed. L Unnevehr, D Grace, Focus 20, Brief 3. Washington, DC: Int. Food Policy Res. Inst. http://www.ifpri.org/sites/default/files/publications/focus20.pdf

10.1021/jf072697e

10.1080/19440041003639582

10.1093/toxsci/kft132

10.1093/toxsci/kft033

10.1093/toxsci/kfs286

10.1111/j.1756-185X.2010.01568.x

10.1111/j.1756-185X.2010.01530.x

Yeh FC, 1986, Ma Zui Xue Za Zhi, 24, 216

Yeh FS, 1989, Cancer Res., 49, 2506

Yoshizawa T. 1983. Trichothecenes—Chemical, Biological, and Toxicological Aspects (Developments in Food Science), ed. Y Ueno, pp. 195–209. Tokyo, Japan: Kodansha Ltd.

10.2527/jas1983.573655x

10.1016/S0168-8278(97)80178-X

10.1080/15287399009531427

Thông tin
Thông tin xuất bản

Annual review of food science and technology

Tập 5 Số 1

351-372

Thông tin tác giả