Psychosocial Vulnerabilities to Upper Respiratory Infectious Illness: Implications for Susceptibility to Coronavirus Disease 2019 (COVID-19)

Perspectives on Psychological Science - Tập 16 Số 1 - Trang 161-174 - 2021
Sheldon Cohen1
1Department of Psychology, Carnegie Mellon University

Tóm tắt

For 35 years, our laboratory has been involved in identifying psychosocial factors that predict who becomes ill when they are exposed to a virus affecting the upper respiratory tract. To pursue this question, we used a unique viral-challenge design in which we assessed behavioral, social, and psychological factors in healthy adults. We subsequently exposed these adults to a cold or influenza virus and then monitored them in quarantine for 5 to 6 days for onset of respiratory illness. Factors we found to be associated with greater risk of respiratory illnesses after virus exposure included smoking, ingesting an inadequate level of vitamin C, and chronic psychological stress. Those associated with decreased risk included social integration, social support, physical activity, adequate and efficient sleep, and moderate alcohol intake. We cautiously suggest that our findings could have implications for identifying who becomes ill when exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19). This argument is based on evidence that the associations we report are replicable across multiple respiratory viruses and that the pathways found to link psychosocial factors to colds and influenza may play similar roles in COVID-19.

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Tài liệu tham khảo

10.1089/jir.2006.26.309

10.1089/088282403322017884

10.1016/j.pnpbp.2015.09.001

10.1093/ntr/ntaa059

10.1007/s00424-011-1044-0

10.1093/med:psych/9780195126709.003.0003

10.1016/s0140-6736(20)30460-8

Brown G. W., 1989, Life events and illness

10.1097/INF.0b013e3182a4d610

10.3390/nu9111211

10.1097/PSY.0000000000000809

10.1037/0003-066x.59.8.676

10.1001/archinternmed.2008.505

10.1097/00006842-199903000-00009

10.1001/jama.1997.03540480040036

10.1037//0278-6133.17.3.214

10.1177/1745691616646305

10.1016/s0889-1591(03)00110-7

10.1073/pnas.1118355109

10.1001/jama.298.14.1685

10.1177/0956797614559284

10.1146/annurev-psych-010418-102857

10.2105/AJPH.83.9.1277

10.1056/nejm199108293250903

10.1037/0033-2909.109.1.5

10.1037/0033-2909.98.2.310

10.1001/jama.2020.3072

10.2500/105065888781692961

10.1007/s11882-005-0034-8

10.2147/vhrm.2006.2.3.239

10.1001/archinternmed.2009.237

10.18332/tid/121915

Gwaltney J. M., 1988, Diagnostic procedures for viral, rickettsial, and chlamydial infections, 6, 579

10.1016/j.bbi.2020.05.059

10.1172/jci1355

10.1002/14651858.CD000980.pub4

10.1073/pnas.1605554113

10.1371/journal.pmed.1000316

10.1016/S0140-6736(20)30183-5

10.1146/annurev-psych-010213-115205

10.1002/14651858.CD006207.pub4

10.1016/j.neubiorev.2009.09.003

10.1037//0022-006x.70.3.537

10.1097/EDE.0b013e318187a7b0

10.1016/j.jinf.2019.08.014

Lazarus R. S., 1984, Stress, appraisal, and coping

10.1038/d41586-020-01824-5

10.1002/jmv.25801

10.1097/JES.0b013e3181b7b57b

10.1586/14760584.2014.924405

10.1037//0278-6133.21.6.531

10.1001/jama.291.10.1238

10.5664/jcsm.8502

10.1249/00005768-199402000-00002

10.1001/jama.2020.0757

10.1097/PSY.0b013e3181f1d003

10.5665/sleep.4968

10.1161/01.Cir.98.8.731

10.1037/a0031859

10.1017/s0007114507838049

10.1126/sciimmunol.abd0110

Sarkar D., 2015, Alcohol Research: Current Reviews, 37, 153

10.1016/s1473-3099(13)70286-x

10.1016/j.amepre.2003.09.005

10.12987/yale/9780300102185.001.0001

10.1037/hea0000594

10.18332/tid/119324

10.1101/2020.03.02.20029975

10.1186/s12971-016-0101-z

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Perspectives on Psychological Science

Tập 16 Số 1

161-174

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