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Prucalopride: Một Đánh Giá Về Việc Sử Dụng Trong Quản Lý Tình Trạng Táo Bón Mãn Tính
Tóm tắt
Chất chủ vận thụ thể serotonin 5-HT4 chọn lọc cao prucalopride (Resolor®, Resotran®, Resotrans®) được chỉ định để điều trị táo bón mãn tính. Trong bốn thử nghiệm ngẫu nhiên, mù đôi, đa trung tâm kéo dài 12 tuần trên bệnh nhân (chủ yếu là phụ nữ) mắc táo bón mãn tính, việc sử dụng prucalopride 2 mg đường uống mỗi ngày một lần đã cải thiện chức năng ruột một cách đáng kể hơn so với giả dược, với tỷ lệ lớn hơn đáng kể những bệnh nhân nhận prucalopride đạt được trung bình ≥3 lần đại tiện tự phát, đầy đủ mỗi tuần (điểm cuối chính). Cải thiện đáng kể hơn trong chất lượng cuộc sống liên quan đến sức khỏe, sự hài lòng của bệnh nhân với điều trị và thói quen đại tiện, cùng với nhiều triệu chứng liên quan đến táo bón cũng được ghi nhận với prucalopride so với giả dược. Sự hài lòng với điều trị và thói quen đại tiện được duy trì với prucalopride trong thời gian dài. Prucalopride nói chung được dung nạp tốt ở bệnh nhân mắc táo bón mãn tính, với các tác dụng phụ thường gặp nhất (đau đầu, buồn nôn, đau bụng, tiêu chảy) chủ yếu xảy ra vào ngày đầu tiên điều trị. Trong suốt các thử nghiệm lâm sàng, không có vấn đề an toàn tim mạch nào phát sinh ở bệnh nhân táo bón mãn tính nhận prucalopride. Kết luận, prucalopride là một lựa chọn quan trọng cho việc sử dụng ở bệnh nhân mắc táo bón mãn tính mà không có sự giảm nhẹ đầy đủ với thuốc nhuận tràng.
Từ khóa
#prucalopride #táo bón mãn tính #chủ vận thụ thể serotonin 5-HT4 #điều trị #chất lượng cuộc sốngTài liệu tham khảo
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