Nội dung được dịch bởi AI, chỉ mang tính chất tham khảo
Hồ sơ proteomic của các nơron ở chuột có hành vi giống trầm cảm do corticosterone gây ra và sự điều chỉnh của berberine: các vị trí quan trọng của phosphorylation oxy hóa
Tóm tắt
Áp lực corticosterone (CORT) mãn tính là một yếu tố gây ra lo âu và trầm cảm liên quan đến sự rối loạn của thụ thể glucocorticoid (GR), yếu tố dinh dưỡng thần kinh có nguồn gốc từ não (BDNF) và tính dẻo của nơron. Tuy nhiên, việc điều chỉnh các hồ sơ proteomic trong các nơron chịu ảnh hưởng bởi áp lực CORT vẫn chưa được làm sáng tỏ. Do đó, các hồ sơ proteomic của tế bào gốc nơron chuột C17.2 đã được điều tra toàn diện thông qua phương pháp proteomics định lượng gán nhãn TMT (tandem mass tag). Phân tích gen ontology kết hợp với proteomics định lượng đã tiết lộ tác động ức chế của CORT đến sự biểu hiện của các protein liên quan đến phosphorylation oxy hóa ti thể, điều này có thể bị antagonized bởi điều trị bằng berberine (BBR). Thêm vào đó, các nghiên cứu trên động vật cho thấy rằng những thay đổi ở ti thể do CORT gây ra có thể ảnh hưởng đến các hoạt động tâm thần kinh và làm suy giảm các chức năng sinh lý của nơron thông qua việc gây rối loạn phosphorylation oxy hóa ti thể. Do đó, quá trình chuyển hóa năng lượng ti thể có thể được coi là một trong những cơ chế chính gây ra trầm cảm do CORT. Vì CORT có vai trò quan trọng trong trầm cảm sau rối loạn căng thẳng sau chấn thương, nghiên cứu của chúng tôi sẽ làm sáng tỏ vấn đề phòng ngừa và điều trị trầm cảm cũng như rối loạn căng thẳng sau chấn thương (PTSD).
Từ khóa
#Corticosterone; trầm cảm; stress mãn tính; proteomics; phosphorylation oxy hóa; berberine; rối loạn căng thẳng sau chấn thương (PTSD)Tài liệu tham khảo
citation_journal_title=Clin Psychol Rev; citation_title=Depression: cognitive perspectives; citation_author=J LeMoult, IH Gotlib; citation_volume=69; citation_publication_date=2019; citation_pages=51-66; citation_doi=10.1016/j.cpr.2018.06.008; citation_id=CR1
citation_journal_title=Neurosci Biobehav Rev; citation_title=Stress, epigenetics and depression: a systematic review; citation_author=C Park, JD Rosenblat, E Brietzke, Z Pan, Y Lee, B Cao; citation_volume=102; citation_publication_date=2019; citation_pages=139-152; citation_doi=10.1016/j.neubiorev.2019.04.010; citation_id=CR2
citation_journal_title=Nat Neurosci; citation_title=Neuroimmune mechanisms of depression; citation_author=GE Hodes, V Kana, C Menard, M Merad, SJ Russo; citation_volume=18; citation_issue=10; citation_publication_date=2015; citation_pages=1386-1393; citation_doi=10.1038/nn.4113; citation_id=CR3
citation_journal_title=Neurosci Bull; citation_title=Inflammation: a mechanism of depression?; citation_author=QQ Han, J Yu; citation_volume=30; citation_issue=3; citation_publication_date=2014; citation_pages=515-523; citation_doi=10.1007/s12264-013-1439-3; citation_id=CR4
citation_journal_title=Biol Psychiatry; citation_title=Stress, depression, and inflammation: molecular and microglial mechanisms; citation_author=DJ Stein, PJ Naudé, M Berk; citation_volume=83; citation_issue=1; citation_publication_date=2018; citation_pages=5-6; citation_doi=10.1016/j.biopsych.2017.10.025; citation_id=CR5
citation_journal_title=Curr Top Behav Neurosci; citation_title=Mechanisms of inflammation-associated depression: immune influences on tryptophan and phenylalanine metabolisms; citation_author=B Strasser, B Sperner-Unterweger, D Fuchs, JM Gostner; citation_volume=31; citation_publication_date=2017; citation_pages=3-30; citation_id=CR6
citation_journal_title=Mol Neurobiol; citation_title=The ERK pathway: molecular mechanisms and treatment of depression; citation_author=JQ Wang, L Mao; citation_volume=56; citation_issue=9; citation_publication_date=2019; citation_pages=6197-6205; citation_doi=10.1007/s12035-019-1524-3; citation_id=CR7
citation_journal_title=Neuropharmacology.; citation_title=Mechanisms underpinning AMP-activated protein kinase-related effects on behavior and hippocampal neurogenesis in an animal model of depression; citation_author=T Odaira, O Nakagawasai, K Takahashi, W Nemoto, W Sakuma, JR Lin, K Tan-No; citation_volume=150; citation_publication_date=2019; citation_pages=121-133; citation_doi=10.1016/j.neuropharm.2019.03.026; citation_id=CR8
citation_journal_title=J Cell Mol Med; citation_title=The molecular mechanism underlying GABAergic dysfunction in nucleus accumbens of depression-like behaviours in mice; citation_author=K Ma, H Zhang, S Wang, H Wang, Y Wang, J Liu; citation_volume=23; citation_publication_date=2019; citation_pages=7021-7028; citation_doi=10.1111/jcmm.14596; citation_id=CR9
citation_journal_title=Psychiatry Clin Neurosci; citation_title=Epigenetic mechanisms of major depression: targeting neuronal plasticity; citation_author=S Uchida, H Yamagata, T Seki, Y Watanabe; citation_volume=72; citation_issue=4; citation_publication_date=2018; citation_pages=212-227; citation_doi=10.1111/pcn.12621; citation_id=CR10
citation_journal_title=Oxidative Medicine and Cellular Longevity; citation_title=Role and Possible Mechanisms of Sirt1 in Depression; citation_author=Guofang Lu, Jianguo Li, Hongmei Zhang, Xin Zhao, Liang-Jun Yan, Xiaorong Yang; citation_volume=2018; citation_publication_date=2018; citation_pages=1-6; citation_id=CR11
citation_journal_title=Stress Neuroendocrinol Neurobiol; citation_title=Stress and major depression: neuroendocrine and biopsychosocial mechanisms; citation_author=A Roy, RN Roy; citation_volume=2; citation_publication_date=2017; citation_pages=173-184; citation_doi=10.1016/B978-0-12-802175-0.00017-6; citation_id=CR12
citation_journal_title=J Exp Biol; citation_title=Epigenetic mechanisms underlying the role of brain-derived neurotrophic factor in depression and response to antidepressants; citation_author=F Duclot, M Kabbaj; citation_volume=218; citation_issue=1; citation_publication_date=2015; citation_pages=21-31; citation_doi=10.1242/jeb.107086; citation_id=CR13
citation_journal_title=Eur J Pharmacol; citation_title=Molecular aspects of depression: a review from neurobiology to treatment; citation_author=GR Villas Boas, R Boerngen de Lacerda, MM Paes, P Gubert, WLDC Almeida, VC Rescia; citation_volume=851; citation_publication_date=2019; citation_pages=99-121; citation_doi=10.1016/j.ejphar.2019.02.024; citation_id=CR14
citation_journal_title=J Psychiatr Res; citation_title=Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder; citation_author=A Medina, AF Seasholtz, V Sharma, S Burke, W Bunney, RM Myers; citation_volume=47; citation_issue=3; citation_publication_date=2013; citation_pages=307-314; citation_doi=10.1016/j.jpsychires.2012.11.002; citation_id=CR15
citation_journal_title=Steroids.; citation_title=Membrane-initiated nuclear trafficking of the glucocorticoid receptor in hypothalamic neurons; citation_author=JR Rainville, GL Weiss, N Evanson, JP Herman, N Vasudevan, JG Tasker; citation_volume=142; citation_publication_date=2019; citation_pages=55-64; citation_doi=10.1016/j.steroids.2017.12.005; citation_id=CR16
citation_journal_title=Aging Neuropsychol Cog; citation_title=Examining HPA-axis functioning as a mediator of the relationship between depression and cognition across the adult lifespan; citation_author=AJ Karstens, I Korzun, ET Avery, MT Kassel, R Keelan, H Kales; citation_volume=26; citation_issue=4; citation_publication_date=2019; citation_pages=507-520; citation_doi=10.1080/13825585.2018.1495309; citation_id=CR17
citation_journal_title=Eur Arch Psychiatry Clin Neurosci; citation_title=Reduced hippocampal neurogenesis in the GR+/− genetic mouse model of depression; citation_author=G Kronenberg, I Kirste, D Inta, S Chourbaji, I Heuser, M Endres; citation_volume=259; citation_issue=8; citation_publication_date=2009; citation_pages=499-504; citation_doi=10.1007/s00406-009-0036-y; citation_id=CR18
citation_journal_title=PLoS One; citation_title=The different roles of glucocorticoids in the hippocampus and hypothalamus in chronic stress-induced HPA axis hyperactivity; citation_author=LJ Zhu, MY Liu, H Li, X Liu, C Chen, Z Han; citation_volume=9; citation_issue=5; citation_publication_date=2014; citation_pages=e97689; citation_doi=10.1371/journal.pone.0097689; citation_id=CR19
citation_journal_title=Psychoneuroendocrinology.; citation_title=Glucocorticoid receptor translocation and expression of relevant genes in the hippocampus of adolescent and adult male rats; citation_author=MR Green, RE Nottrodt, JJ Simone, CM McCormick; citation_volume=73; citation_publication_date=2016; citation_pages=32-41; citation_doi=10.1016/j.psyneuen.2016.07.210; citation_id=CR20
citation_journal_title=Hippocampus.; citation_title=Interactions between N-Ethylmaleimide-sensitive factor and GluA2 contribute to effects of glucocorticoid hormones on AMPA receptor function in the rodent hippocampus; citation_author=H Xiong, F Cassé, M Zhou, ZQ Xiong, M Joels, S Martin; citation_volume=26; citation_issue=7; citation_publication_date=2016; citation_pages=848-856; citation_doi=10.1002/hipo.22567; citation_id=CR21
citation_journal_title=J Mol Neurosci; citation_title=TPPU, a sEH inhibitor, attenuates corticosterone- induced PC12 cell injury by modulation of BDNF-TrkB pathway; citation_author=Q Wu, J Song, D Meng, Q Chang; citation_volume=67; citation_issue=3; citation_publication_date=2019; citation_pages=364-372; citation_doi=10.1007/s12031-018-1230-z; citation_id=CR22
citation_journal_title=Brain Res; citation_title=Pharmacological characterization of repeated corticosterone injection-induced depression model in rats; citation_author=M Iijima, A Ito, S Kurosu, S Chaki; citation_volume=1359; citation_publication_date=2010; citation_pages=75-80; citation_doi=10.1016/j.brainres.2010.08.078; citation_id=CR23
citation_journal_title=Brain Res; citation_title=The varying effects of short-term and long-term corticosterone injections on depression-like behavior in mice; citation_author=Y Zhao, W Xie, J Dai, Z Wang, Y Huang; citation_volume=1261; citation_publication_date=2009; citation_pages=82-90; citation_doi=10.1016/j.brainres.2008.12.083; citation_id=CR24
citation_journal_title=Life Sci; citation_title=Kinetic difference of berberine between hippocampus and plasma in rat after intravenous administration of Coptidis rhizoma extract; citation_author=X Wang, R Wang, D Xing, H Su, C Ma, Y Ding; citation_volume=77; citation_issue=24; citation_publication_date=2005; citation_pages=3058-3067; citation_doi=10.1016/j.lfs.2005.02.033; citation_id=CR25
citation_journal_title=Am J Chin Med; citation_title=Pharmacokinetics of berberine in rat thalamus after intravenous administration of coptidis rhizoma extract; citation_author=X Wang, D Xing, W Wang, H Su, J Tao, L Du; citation_volume=33; citation_issue=6; citation_publication_date=2005; citation_pages=935-943; citation_doi=10.1142/S0192415X05003557; citation_id=CR26
citation_journal_title=Neurosci Lett; citation_title=The uptake and transport behavior of berberine in Coptidis Rhizoma extract through rat primary cultured cortical neurons; citation_author=X Wang, D Xing, W Wang, F Lei, H Su, L Du; citation_volume=379; citation_issue=2; citation_publication_date=2005; citation_pages=132-137; citation_doi=10.1016/j.neulet.2004.12.050; citation_id=CR27
citation_journal_title=Biomed Chrom; citation_title=Characterization of the transportation of berberine in Coptidis rhizoma extract through rat primary cultured cortical neurons; citation_author=Y Chen, X Wang, H Sun, D Xing, J Hu, Z Wai; citation_volume=22; citation_issue=1; citation_publication_date=2008; citation_pages=28-33; citation_doi=10.1002/bmc.889; citation_id=CR28
citation_journal_title=Exp Therap Med; citation_title=Berberine alleviates amyloid β25-35-induced inflammatory response in human neuroblastoma cells by inhibiting proinflammatory factors; citation_author=J Xu, W Wu, H Zhang, LI Yang; citation_volume=16; citation_issue=6; citation_publication_date=2018; citation_pages=4865-4872; citation_id=CR29
citation_journal_title=Eur J Pharmacol; citation_title=PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia–reperfusion; citation_author=J Hu, Y Chai, Y Wang, MM Kheir, H Li, Z Yuan; citation_volume=2; citation_publication_date=2012; citation_pages=132-142; citation_doi=10.1016/j.ejphar.2011.11.014; citation_id=CR30
citation_journal_title=Mol Med Reports; citation_title=Neuroprotective effect of berberine agonist against impairment of learning and memory skills in severe traumatic brain injury via Sirt1/p38 MAPK expression; citation_author=J Wang, Y Zhang; citation_volume=17; citation_issue=5; citation_publication_date=2018; citation_pages=6881-6886; citation_id=CR31
citation_journal_title=Neuropharmacology; citation_title=Adenosine monophosphate-activated protein kinase modulation by berberine attenuates mitochondrial deficits and redox imbalance in experimental diabetic neuropathy; citation_author=VG Yerra, AK Kalvala, B Sherkhane, A Areti, A Kumar; citation_volume=131; citation_publication_date=2018; citation_pages=256-270; citation_doi=10.1016/j.neuropharm.2017.12.029; citation_id=CR32
citation_journal_title=Neurosci Lett; citation_title=Berberine up-regulates the BDNF expression in hippocampus and attenuates corticosterone-induced depressive- like behavior in mice; citation_author=JD Shen, LG Ma, CY Hu, YY Pei, SL Jin, XY Fang; citation_volume=614; citation_publication_date=2016; citation_pages=77-82; citation_doi=10.1016/j.neulet.2016.01.002; citation_id=CR33
citation_journal_title=Brain Res Bull; citation_title=Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice; citation_author=YM Liu, L Niu, LL Wang, L Bai, XY Fang, YC Li, L-T Yi; citation_volume=134; citation_publication_date=2017; citation_pages=220-227; citation_doi=10.1016/j.brainresbull.2017.08.008; citation_id=CR34
citation_journal_title=Pharmacognosy Mag; citation_title=Berberine ameliorates chronic unpredictable mild stress induced depression like behaviors and elevating kelch-like erythroid cell-derived protein with CNC homology-associated protein 1-nuclear factor (erythroid-derived 2)-like 2 antioxidant signaling pathways; citation_author=W Gao, Z Deng, X Liu, J Hu, P Deng, L Chi; citation_volume=14; citation_issue=56; citation_publication_date=2018; citation_pages=371-377; citation_doi=10.4103/pm.pm_181_17; citation_id=CR35
citation_journal_title=Korean J Physiol Pharmacol; citation_title=Effect of berberine on depression- and anxiety-like behaviors and activation of the noradrenergic system induced by development of morphine dependence in rats; citation_author=B Lee, B Sur, M Yeom, I Shim, H Lee, DH Hahm; citation_volume=16; citation_issue=6; citation_publication_date=2012; citation_pages=379-386; citation_doi=10.4196/kjpp.2012.16.6.379; citation_id=CR36
citation_journal_title=National Med J Chin; citation_title=The effect of berberine on ameliorating chronic inflammatory pain and depression; citation_author=F Xu, J Yang, B Meng, J Zheng, Q Liao, J Chen; citation_volume=98; citation_issue=14; citation_publication_date=2018; citation_pages=1103-1108; citation_id=CR37
citation_journal_title=J Neurobiol; citation_title=Establishment and characterization of multipotent neural cell lines using retrovirus vector-mediated oncogene transfer; citation_author=EF Ryder, EY Snyder, CL Cepko; citation_volume=2; citation_publication_date=1990; citation_pages=356-375; citation_doi=10.1002/neu.480210209; citation_id=CR38
citation_journal_title=Cell.; citation_title=Multipotent neural cell lines can engraft and participate in development of mouse cerebellum; citation_author=EY Snyder, DL Deitcher, C Walsh, S Arnold-Aldea, EA Hartwieg, CL Cepko; citation_volume=1; citation_publication_date=1992; citation_pages=33-51; citation_doi=10.1016/0092-8674(92)90204-P; citation_id=CR39
citation_journal_title=Eur J Pharmacol; citation_title=Effect of berberine on cell cycle arrest and cell survival during cerebral ischemia and reperfusion and correlations with p53/cyclin D1 and PI3K/Akt; citation_author=YS Chai, J Hu, F Lei, YG Wang, ZY Yuan, X Lu; citation_volume=708; citation_issue=1–3; citation_publication_date=2013; citation_pages=44-55; citation_doi=10.1016/j.ejphar.2013.02.041; citation_id=CR40
citation_journal_title=Nat Protoc; citation_title=Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources; citation_author=DW Huang, BT Sherman, RA Lempicki; citation_volume=1; citation_publication_date=2009; citation_pages=44-57; citation_doi=10.1038/nprot.2008.211; citation_id=CR41
citation_journal_title=J Chin Pharm Sci; citation_title=Proteomic changes in rat kidney injured by adenine and the regulation of anemoside B4; citation_author=L He, Q Gong, X Yu, M Wang, S Wong, F Lei; citation_volume=28; citation_issue=1; citation_publication_date=2019; citation_pages=10-20; citation_doi=10.5246/jcps.2019.01.002; citation_id=CR42
citation_journal_title=Sci Signal; citation_title=Proteomics profiling of arginine methylation defines PRMT5 substrate specificity; citation_author=D Musiani, J Bok, E Massignani, L Wu, T Tabaglio, MR Ippolito; citation_volume=12; citation_issue=575; citation_publication_date=2019; citation_pages=eaat8388; citation_doi=10.1126/scisignal.aat8388; citation_id=CR43
citation_journal_title=Eur J of Pharmacol; citation_title=A mouse model of depression induced by repeated corticosterone injections; citation_author=Y Zhao, R Ma, J Shen, H Su, D Xing, L Du; citation_volume=581; citation_issue=1–2; citation_publication_date=2008; citation_pages=113-120; citation_doi=10.1016/j.ejphar.2007.12.005; citation_id=CR44
citation_journal_title=Physiol Behav; citation_title=In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions; citation_author=T Demuyser, L Deneyer, E Bentea, G Albertini, J Liefferinge, E Merckx; citation_volume=156; citation_publication_date=2016; citation_pages=199-207; citation_doi=10.1016/j.physbeh.2015.12.018; citation_id=CR45
citation_journal_title=Sci Rep; citation_title=TRPM8 in the negative regulation of TNFα expression during cold stress; citation_author=XP Wang, X Yu, XJ Yan, F Lei, YS Chai, JF Jiang; citation_volume=7; citation_publication_date=2017; citation_pages=e45155; citation_doi=10.1038/srep45155; citation_id=CR46
citation_journal_title=Chin J Nat Med; citation_title=Mechanism underlying berberine's effects on HSP70/TNFα under heat stress: correlation with the TATA boxes; citation_author=JF Jiang, F Lei, ZY Yuan, YG Wang, XP Wang, XJ Yan; citation_volume=15; citation_issue=3; citation_publication_date=2017; citation_pages=178-191; citation_id=CR47
citation_journal_title=Food Chem Toxicol; citation_title=Acute toxicity of berberine and its correlation with the blood concentration in mice; citation_author=MM Kheir, Y Wang, L Hua, J Hu, L Li, F Lei; citation_volume=48; citation_issue=4; citation_publication_date=2010; citation_pages=1105-1110; citation_doi=10.1016/j.fct.2010.01.033; citation_id=CR48
citation_journal_title=Neurotoxicol Teratol; citation_title=Metabolomics studies on corticosterone-induced PC12 cells: a strategy for evaluating an in vitro depression model and revealing the metabolic regulation mechanism; citation_author=JS Tian, SB Liu, XY He, H Xiang, JL Chen, Y Gao; citation_volume=69; citation_publication_date=2018; citation_pages=27-38; citation_doi=10.1016/j.ntt.2018.07.002; citation_id=CR49
citation_journal_title=Neuropharmacology.; citation_title=Ndesalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells, a putative cellular mechanism for quetiapine as antidepressant; citation_author=B Benedetto, R Kuhn, C Nothdurfter, T Rein, W Wurst, R Rupprecht; citation_volume=62; citation_publication_date=2012; citation_pages=209-216; citation_doi=10.1016/j.neuropharm.2011.07.001; citation_id=CR50
citation_journal_title=Cell Mol Neurobiol; citation_title=17beta-estradiol-induced regulation of the novel 5-HT1A-related transcription factors NUDR and Freud-1 in SH SY5Y cells; citation_author=SO Adeosun, PR Albert, MC Austin, AH Iyo; citation_volume=32; citation_publication_date=2012; citation_pages=517-521; citation_doi=10.1007/s10571-012-9809-3; citation_id=CR51
citation_journal_title=Biomed Pharmacother; citation_title=Protective effect of pig brain polypeptides against corticosterone-induced oxidative stress, inflammatory response, and apoptosis in PC12 cells; citation_author=W Jin, X Xu, X Chen, W Qi, J Lu, X Yan; citation_volume=115; citation_publication_date=2019; citation_pages=e108890; citation_doi=10.1016/j.biopha.2019.108890; citation_id=CR52
citation_journal_title=Nat Med; citation_title=Astrocyte-derived ATP modulates depressive-like behaviors; citation_author=X Cao, LP Li, Q Wang, Q Wu, HH Hu, M Zhang; citation_volume=19; citation_publication_date=2013; citation_pages=773-777; citation_doi=10.1038/nm.3162; citation_id=CR53
citation_journal_title=Prog Neuro-Psychopharmacol Biol Psychiatry; citation_title=Hippocampal astrocyte atrophy in a mouse depression model induced by corticosterone is reversed by fluoxetine instead of benzodiazepine diazepam; citation_author=Y Zhao, Z Lin, L Chen, L Ouyang, L Gu, F Chen; citation_volume=83; citation_publication_date=2018; citation_pages=99-109; citation_doi=10.1016/j.pnpbp.2018.01.011; citation_id=CR54
citation_journal_title=CNS Neurosci Ther; citation_title=A novel PDE9 inhibitor WYQ-C36D ameliorates corticosterone-induced neurotoxicity and depression-like behaviors by cGMP-CREB-related signaling; citation_author=XF Huang, WT Jiang, L Liu, FC Song, X Zhu, GL Shi; citation_volume=24; citation_issue=10; citation_publication_date=2018; citation_pages=889-896; citation_doi=10.1111/cns.12864; citation_id=CR55
citation_journal_title=Oxidative Med Cell Longev; citation_title=Combined respiratory chain deficiency and UQCC2 mutations in neonatal encephalomyopathy: defective supercomplex assembly in complex III deficiencies; citation_author=RG Feichtinger, M Brunner-Krainz, B Alhaddad, SB Wortmann, R Kovacs-Nagy, T Stojakovic; citation_volume=2017; citation_publication_date=2017; citation_pages=e7202589; citation_id=CR56
citation_journal_title=Nature.; citation_title=Mitonuclear protein imbalance as a conserved longevity mechanism; citation_author=RH Houtkooper, L Mouchiroud, D Ryu, N Moullan, E Katsyuba, G Knott; citation_volume=497; citation_issue=7450; citation_publication_date=2013; citation_pages=451-457; citation_doi=10.1038/nature12188; citation_id=CR57
citation_journal_title=Cell.; citation_title=The NAD+/sirtuin pathway modulates longevity through activation of mitochondrial UPR and FOXO signaling; citation_author=L Mouchiroud, RH Houtkooper, N Moullan, E Katsyuba, D Ryu, C Cantó; citation_volume=154; citation_issue=2; citation_publication_date=2013; citation_pages=430; citation_doi=10.1016/j.cell.2013.06.016; citation_id=CR58
citation_journal_title=Front Genet; citation_title=Genetic analysis of mitochondrial ribosomal proteins and cognitive aging in postmenopausal women; citation_author=K Mozhui, BM Snively, SR Rapp, RB Wallace, RW Williams, KC Johnson; citation_volume=8; citation_publication_date=2017; citation_pages=e127; citation_doi=10.3389/fgene.2017.00127; citation_id=CR59
citation_journal_title=PLoS One; citation_title=Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury; citation_author=K Kysenius, CA Brunello, HJ Huttunen; citation_volume=9; citation_issue=9; citation_publication_date=2014; citation_pages=e107129; citation_doi=10.1371/journal.pone.0107129; citation_id=CR60
citation_journal_title=Sci Rep; citation_title=Mitochondria play an important role in the cell proliferation suppressing activity of berberine; citation_author=XJ Yan, X Yu, XP Wang, JF Jiang, ZY Yuan, X Lu; citation_volume=7; citation_publication_date=2017; citation_pages=e41712; citation_doi=10.1038/srep41712; citation_id=CR61
citation_journal_title=Behav Brain Res; citation_title=Antidepressant-like effects of cortex Mori Radicis extract via bidirectional phosphorylation of glucocorticoid receptors in the hippocampus; citation_author=MS Lee, WS Park, YH Kim, SH Kwon, YJ Jang, D Han; citation_volume=236; citation_issue=1; citation_publication_date=2013; citation_pages=56-61; citation_doi=10.1016/j.bbr.2012.08.028; citation_id=CR62
citation_journal_title=Mol Brain; citation_title=Glucocorticoid receptor represses brain-derived neurotrophic factor expression in neuron-like cells; citation_author=H Chen, M Lombès, D Menuet; citation_volume=10; citation_issue=1; citation_publication_date=2017; citation_pages=e12; citation_doi=10.1186/s13041-017-0295-x; citation_id=CR63
citation_journal_title=Mol Psychiatry; citation_title=Knockdown of the glucocorticoid receptor alters functional integration of newborn neurons in the adult hippocampus and impairs fear-motivated behavior; citation_author=TG Schouten, DJ Saaltink, T Dijkmans, DA Steindler, J Verhaagen, FJ Verbeek; citation_volume=18; citation_issue=9; citation_publication_date=2013; citation_pages=993-1005; citation_doi=10.1038/mp.2012.123; citation_id=CR64
citation_journal_title=Neurosci Lett; citation_title=Depression-like behaviors induced by chronic corticosterone exposure via drinking water: time-course analysis; citation_author=H Ding, XY Cui, SY Cui, H Ye, X Hu, HL Zhao; citation_volume=687; citation_publication_date=2018; citation_pages=202-206; citation_doi=10.1016/j.neulet.2018.09.059; citation_id=CR65
citation_journal_title=Evid Based Complementary Alternat Med; citation_title=Novel antidepressant-like activity of caffeic acid phenethyl ester is mediated by enhanced glucocorticoid receptor function in the hippocampus; citation_author=MS Lee, YH Kim, BR Lee, SH Kwon, WJ Moon, KS Hong; citation_volume=2014; citation_publication_date=2014; citation_pages=e646039; citation_id=CR66
citation_journal_title=Sci Rep; citation_title=TATA boxes in gene transcription and poly (A) tails in mRNA stability: new perspective on the effects of berberine; citation_author=ZY Yuan, X Lu, F Lei, YS Chai, YG Wang, JF Jiang; citation_volume=5; citation_publication_date=2015; citation_pages=e18326; citation_doi=10.1038/srep18326; citation_id=CR67
citation_journal_title=PLoS One; citation_title=Inhibition of retinoblastoma mRNA degradation through poly (A) involved in the neuroprotective effect of berberine against cerebral ischemia; citation_author=YS Chai, ZY Yuan, F Lei, YG Wang, J Hu, F Du; citation_volume=9; citation_issue=3; citation_publication_date=2014; citation_pages=e90850; citation_doi=10.1371/journal.pone.0090850; citation_id=CR68
citation_journal_title=PLoS One; citation_title=Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box; citation_author=Y Wang, MM Kheir, Y Chai, J Hu, D Xing, F Lei; citation_volume=6; citation_issue=8; citation_publication_date=2011; citation_pages=e23495; citation_doi=10.1371/journal.pone.0023495; citation_id=CR69
citation_journal_title=J Chin Pharm Sci; citation_title=Berberine inhibits mRNA degradation by promoting the interaction between the poly A tail and its binding protein PABP; citation_author=Z Yuan, X Lu, F Lei, J Hu, Y Wang, Y Chai; citation_volume=26; citation_issue=1; citation_publication_date=2017; citation_pages=53-62; citation_id=CR70
citation_journal_title=Front Neurosci; citation_title=Mitochondria and mood: mitochondrial dysfunction as a key player in the manifestation of depression; citation_author=J Allen, R Romay-Tallon, KJ Brymer, HJ Caruncho, LE Kalynchuk; citation_volume=12; citation_publication_date=2018; citation_pages=e386; citation_doi=10.3389/fnins.2018.00386; citation_id=CR71
citation_journal_title=Prog Neuro-Psychopharmacol Biol Psychiatry; citation_title=Linking the biological underpinnings of depression: role of mitochondria interactions with melatonin, inflammation, sirtuins, tryptophan catabolites, DNA repair and oxidative and nitrosative stress, with consequences for classification and cognition; citation_author=G Anderson; citation_volume=80; citation_publication_date=2018; citation_pages=255-266; citation_doi=10.1016/j.pnpbp.2017.04.022; citation_id=CR72
citation_journal_title=Cell.; citation_title=Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization; citation_author=Z Li, J Jo, JM Jia, SC Lo, DJ Whitcomb, S Jiao; citation_volume=141; citation_issue=5; citation_publication_date=2010; citation_pages=859-871; citation_doi=10.1016/j.cell.2010.03.053; citation_id=CR73
citation_journal_title=Int J Mol Sci; citation_title=Mitochondria and energetic depression in cell pathophysiology; citation_author=E Seppet, M Gruno, A Peetsalu, Z Gizatullina, HP Nguyen, S Vielhaber; citation_volume=10; citation_issue=5; citation_publication_date=2009; citation_pages=2252-2303; citation_doi=10.3390/ijms10052252; citation_id=CR74
citation_journal_title=Mol Neurobiol; citation_title=The effect of chronic tianeptine administration on the brain mitochondria: direct links with an animal model of depression; citation_author=K Głombik, A Stachowicz, R Olszanecki, J Ślusarczyk, E Trojan, W Lasoń; citation_volume=53; citation_issue=10; citation_publication_date=2016; citation_pages=7351-7362; citation_doi=10.1007/s12035-016-9807-4; citation_id=CR75
citation_journal_title=Mitochondrion.; citation_title=Depressive behaviour in children diagnosed with a mitochondrial disorder; citation_author=E Morava, T Gardeitchik, T Kozicz, L Boer, S Koene, MC Vries; citation_volume=10; citation_publication_date=2010; citation_pages=528-533; citation_doi=10.1016/j.mito.2010.05.011; citation_id=CR76
citation_journal_title=Psychosomatics.; citation_title=Review of the literature on mMajor mental disorders in adult patients with mitochondrial diseases; citation_author=O Fattal, K Budur, AJ Vaughan, K Franco; citation_volume=47; citation_publication_date=2006; citation_pages=1-7; citation_doi=10.1176/appi.psy.47.1.1; citation_id=CR77